Nanog

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== Disease ==
== Disease ==
Nanog as many pluripotency factors can be disregulated and end up contributing to protumorigenic proporties. These transcription factors are frequently detected in malignant tumours, where there are Cancer Stem Cells (CSC´s), wich recapitulate the expression of Embrionic Stem Cell associated proteins. Nanog is detected in a wide variety of cancers alongside other very well known transcription factor ,such as the Yamanaka Factors, Oct4 and Sox2 [9].
Nanog as many pluripotency factors can be disregulated and end up contributing to protumorigenic proporties. These transcription factors are frequently detected in malignant tumours, where there are Cancer Stem Cells (CSC´s), wich recapitulate the expression of Embrionic Stem Cell associated proteins. Nanog is detected in a wide variety of cancers alongside other very well known transcription factor ,such as the Yamanaka Factors, Oct4 and Sox2 [9].
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Nanog expression in tumours has been correlated with a worse prognosis, metastatic properties, tissue invasiveness and chemotherapy resistance [6, 7, 8]. A lot of studies have been done to unravel network that pluripotency associated proteins maintain in cancer cells, and yet the link between Nanog and other transcription factors have been stablished, the origin of that expression in cancer cells is yet poorly understood.
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Nanog expression in tumours has been correlated with a worse prognosis, metastatic properties, tissue invasiveness and chemotherapy resistance [6, 7, 8]. Because CSC´s are the most resistent, invasive and proliferative cells, they are also the most probable reason for tumour recurrance after cirurgical removal.
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A lot of studies have been done to unravel the network that pluripotency associated proteins maintain in cancer cells, and yet the link between Nanog and other transcription factors have been stablished, the origin of that expression in cancer cells is still poorly understood.

Revision as of 20:54, 12 June 2019

Nanog (Human homeobox protein)

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References

1. Allouba, M. H., ElGuindy, A. M., Krishnamoorthy, N., Yacoub, M. H., & Aguib, Y. E. (2015). NaNog: A pluripotency homeobox (master) molecule. Global Cardiology Science and Practice, 2015(3), 36.doi:10.5339/gcsp.2015.36

2. Jauch, R. et al. Crystal Structure and DNA Binding of the Homeodomain of the Stem Cell Transcription Factor Nanog. J. Mol. Biol. (2008) 376, 758–770, doi:10.1016/j.jmb.2007.11.091

3. https://www.uniprot.org/uniprot/Q9H9S0

4. Gawlik-Rzemieniewska, N., & Bednarek, I. (2015). The role of NANOG transcriptional factor in the development of malignant phenotype of cancer cells. Cancer Biology & Therapy, 17(1), 1–10.doi:10.1080/15384047.2015.1121348

5. Zhang, W., Sui, Y., Ni, J., & Yang, T. (2016). Insights into the Nanog gene: A propeller for stemness in primitive stem cells. International Journal of Biological Sciences, 12(11), 1372–1381.doi:10.7150/ijbs.16349

6. Sun C, Sun L, Jiang K, et al. NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway. The international journal of biochemistry & cell biology. 2013; 45:1099–1108. [PubMed: 23474366]

7. Chiou SH, Wang ML, Chou YT, et al. Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymaltransdifferentiation. Cancer Res. 2010; 70:10433–10444. [PubMed: 21159654].

8. Jeter CR, Liu B, Liu X, et al. NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene. 2011; 30:3833–3845. [PubMed: 21499299]

9. Liu, Anfei, Xiya Yu, and Shanrong Liu. "Pluripotency transcription factors and cancer stem cells: small genes make a big difference." Chinese journal of cancer 32.9 (2013): 483.

10.Pan, Guangjin, and James A. Thomson. "Nanog and transcriptional networks in embryonic stem cell pluripotency." Cell research 17.1 (2007): 42.

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Caio Felipe de Miranda Costa, Thiago Giove Mitsugi

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