Dual specificity phosphatase
From Proteopedia
(Difference between revisions)
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**[[2nt2]] – hSSH-2L catalytic domain - human<br /> | **[[2nt2]] – hSSH-2L catalytic domain - human<br /> | ||
| - | *Phosphatase of regenerating liver (PRL) | + | *Phosphatase of regenerating liver (PRL) or protein tyrosine phosphatase type IVA |
| + | **[[1rxd]] – hPRL-1 <br /> | ||
**[[1xm2]] – hPRL-1 (mutant)<br /> | **[[1xm2]] – hPRL-1 (mutant)<br /> | ||
| + | **[[5bx1]] – hPRL-1 + inhibitor<br /> | ||
**[[1zck]], [[1x24]] – rPRL-1 - rat<br /> | **[[1zck]], [[1x24]] – rPRL-1 - rat<br /> | ||
| - | **[[1zcl]] – rPRL-1 (mutant)<br /> | + | **[[1zcl]] – rPRL-1 (mutant)<br /> |
| + | **[[3rz2]] – rPRL-1 + peptide<br /> | ||
| + | **[[5mmz]], [[5lxq]] – mPRL-1 + magnesium transporter - mouse<br /> | ||
| + | **[[5k24]] – mPRL-2 + magnesium transporter<br /> | ||
| + | **[[5k25]], [[5k23]] – hPRL-2 + magnesium transporter<br /> | ||
| + | **[[5k22]] – hPRL-2 (mutant) + magnesium transporter<br /> | ||
**[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br /> | **[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br /> | ||
| + | **[[5tsr]] – hPRL-3 + magnesium transporter<br /> | ||
*Cdc14 | *Cdc14 | ||
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**[[1ohc]], [[1ohd]] – hCdc14B2 core domain <br /> | **[[1ohc]], [[1ohd]] – hCdc14B2 core domain <br /> | ||
**[[1ohe]] – hCdc14B2 core domain + peptide<br /> | **[[1ohe]] – hCdc14B2 core domain + peptide<br /> | ||
| + | **[[6g86]] – hCdc14 + SIC1 peptide<br /> | ||
| + | **[[6g85]], [[6g84]] – hCdc14 + CBK1 peptide<br /> | ||
| + | **[[5xw5]] – hCdc14 + SWI6P peptide<br /> | ||
| + | **[[5xw4]] – yCdc14 - yeast<br /> | ||
| + | **[[4zj7]] – yCdc14 C-terminal + importin<br /> | ||
*Cdc25 | *Cdc25 | ||
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**[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant)<br /> | **[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant)<br /> | ||
| + | |||
| + | *Phosphoinositide phosphatase Sac1 | ||
| + | |||
| + | **[[3lwt]] – ySac1<br /> | ||
| + | **[[4tu3]] – ySac1 + VPS74<br /> | ||
| + | |||
| + | *Phosphoinositide phosphatase Sac2 | ||
| + | |||
| + | **[[4xuu]] – hSac2 residues 169-563<br /> | ||
*Myotubularin-related protein (MTMR) | *Myotubularin-related protein (MTMR) | ||
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**[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br /> | **[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br /> | ||
**[[2yf0]] – hMTMR6<br /> | **[[2yf0]] – hMTMR6<br /> | ||
| + | |||
| + | Myotubularin-related protein 15 (MTMR15) or Fanconi-associated nuclease 1 | ||
| + | |||
| + | **[[4rid]], [[4ry3]] – hMTMR15 residues 370-1009<br /> | ||
| + | **[[4rec]], [[4ri8]], [[4ri9]], [[4ria]], [[4rib]], [[4ric]], [[4reb]], [[4rea]] – hMTMR15 (mutant) + DNA<br /> | ||
*MAPK phosphatase see [[MAP kinase phosphatase]] | *MAPK phosphatase see [[MAP kinase phosphatase]] | ||
Revision as of 07:37, 18 June 2019
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3D structures of dual specificity phosphatase
Updated on 18-June-2019
Myotubularin-related protein 15 (MTMR15) or Fanconi-associated nuclease 1
References
- ↑ Patterson KI, Brummer T, O'Brien PM, Daly RJ. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J. 2009 Mar 15;418(3):475-89. doi: 10.1042/bj20082234. PMID:19228121 doi:http://dx.doi.org/10.1042/bj20082234
- ↑ Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC. The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. J Biol Chem. 2007 Nov 2;282(44):32520-8. Epub 2007 Sep 11. PMID:17848544 doi:http://dx.doi.org/10.1074/jbc.M707041200
- ↑ Walls CD, Iliuk A, Bai Y, Wang M, Tao WA, Zhang ZY. Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transduction. Mol Cell Proteomics. 2013 Dec;12(12):3759-77. doi: 10.1074/mcp.M113.028886. Epub , 2013 Sep 12. PMID:24030100 doi:http://dx.doi.org/10.1074/mcp.M113.028886
- ↑ Stegmeier F, Amon A. Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. Annu Rev Genet. 2004;38:203-32. PMID:15568976 doi:http://dx.doi.org/10.1146/annurev.genet.38.072902.093051
- ↑ Kristjansdottir K, Rudolph J. Cdc25 phosphatases and cancer. Chem Biol. 2004 Aug;11(8):1043-51. PMID:15324805 doi:http://dx.doi.org/10.1016/j.chembiol.2004.07.007
- ↑ Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. 1999 Oct 29;99(3):323-34. PMID:10555148
- ↑ Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8660-5. Epub 2003 Jul 7. PMID:12847286 doi:http://dx.doi.org/10.1073/pnas.1033097100
- ↑ Pulido R, Hooft van Huijsduijnen R. Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease. FEBS J. 2008 Mar;275(5):848-66. doi: 10.1111/j.1742-4658.2008.06250.x. PMID:18298792 doi:http://dx.doi.org/10.1111/j.1742-4658.2008.06250.x
- ↑ Berger P, Bonneick S, Willi S, Wymann M, Suter U. Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1. Hum Mol Genet. 2002 Jun 15;11(13):1569-79. PMID:12045210
- ↑ Gray CH, Good VM, Tonks NK, Barford D. The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. EMBO J. 2003 Jul 15;22(14):3524-35. PMID:12853468 doi:10.1093/emboj/cdg348
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