4zgx
From Proteopedia
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==Structure of aldosterone synthase (CYP11B2) in complex with (+)-(R)-N-(4-(4-chloro-3-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide== | ==Structure of aldosterone synthase (CYP11B2) in complex with (+)-(R)-N-(4-(4-chloro-3-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide== | ||
| - | <StructureSection load='4zgx' size='340' side='right' caption='[[4zgx]], [[Resolution|resolution]] 3.20Å' scene=''> | + | <StructureSection load='4zgx' size='340' side='right'caption='[[4zgx]], [[Resolution|resolution]] 3.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4zgx]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZGX FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4zgx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZGX FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=QHC:N-[(8R)-4-(4-CHLORO-3-FLUOROPHENYL)-5,6,7,8-TETRAHYDROISOQUINOLIN-8-YL]PROPANAMIDE'>QHC</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=QHC:N-[(8R)-4-(4-CHLORO-3-FLUOROPHENYL)-5,6,7,8-TETRAHYDROISOQUINOLIN-8-YL]PROPANAMIDE'>QHC</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgx OCA], [http://pdbe.org/4zgx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zgx RCSB], [http://www.ebi.ac.uk/pdbsum/4zgx PDBsum]</span></td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP11B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgx OCA], [http://pdbe.org/4zgx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zgx RCSB], [http://www.ebi.ac.uk/pdbsum/4zgx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zgx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | {{Large structure}} | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/C11B2_HUMAN C11B2_HUMAN]] Familial hyperreninemic hypoaldosteronism type 1;Familial hyperaldosteronism type I. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The molecular defect causing hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2. | [[http://www.uniprot.org/uniprot/C11B2_HUMAN C11B2_HUMAN]] Familial hyperreninemic hypoaldosteronism type 1;Familial hyperaldosteronism type I. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The molecular defect causing hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2. | ||
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</div> | </div> | ||
<div class="pdbe-citations 4zgx" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4zgx" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Joseph, C]] | [[Category: Joseph, C]] | ||
[[Category: Kuglstatter, A]] | [[Category: Kuglstatter, A]] | ||
Revision as of 07:10, 19 June 2019
Structure of aldosterone synthase (CYP11B2) in complex with (+)-(R)-N-(4-(4-chloro-3-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide
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