4z3o
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Quinolone(Moxifloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae== | ==Quinolone(Moxifloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae== | ||
| - | <StructureSection load='4z3o' size='340' side='right' caption='[[4z3o]], [[Resolution|resolution]] 3.44Å' scene=''> | + | <StructureSection load='4z3o' size='340' side='right'caption='[[4z3o]], [[Resolution|resolution]] 3.44Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4z3o]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z3O FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4z3o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z3O FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4koe|4koe]], [[4pxp|4pxp]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[3ksb|3ksb]], [[3ksa|3ksa]], [[4i3h|4i3h]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4koe|4koe]], [[4pxp|4pxp]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[3ksb|3ksb]], [[3ksa|3ksa]], [[4i3h|4i3h]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Z67739 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z3o OCA], [http://pdbe.org/4z3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z3o RCSB], [http://www.ebi.ac.uk/pdbsum/4z3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z3o ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z3o OCA], [http://pdbe.org/4z3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z3o RCSB], [http://www.ebi.ac.uk/pdbsum/4z3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z3o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> | [[http://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Topoisomerase|Topoisomerase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Strpn]] | ||
[[Category: Crevel, I M.T]] | [[Category: Crevel, I M.T]] | ||
[[Category: Fisher, L M]] | [[Category: Fisher, L M]] | ||
Revision as of 07:29, 19 June 2019
Quinolone(Moxifloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae
| |||||||||||
Categories: Large Structures | Strpn | Crevel, I M.T | Fisher, L M | Laponogov, I | Pan, X S | Sanderson, M R | Selvarajah, J | Veselkov, D A | Cleavage complex | Dna | Isomerase | Quinolone | Topo iv
