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Ephrin receptor
From Proteopedia
(Difference between revisions)
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<scene name='45/450911/Cv/10'>Peptide substrate binding site</scene> ([[3fxx]]).<ref>PMID:19678838</ref> | <scene name='45/450911/Cv/10'>Peptide substrate binding site</scene> ([[3fxx]]).<ref>PMID:19678838</ref> | ||
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| + | == 3D Structures of ephrin receptor == | ||
| + | [[Ephrin receptor 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of ephrin receptors == | == 3D Structures of ephrin receptors == | ||
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*Ephrin A1 receptor | *Ephrin A1 receptor | ||
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**[[3kka]] - hEPHR A1 SAM+ hEPH A2 SAM – human<BR /> | **[[3kka]] - hEPHR A1 SAM+ hEPH A2 SAM – human<BR /> | ||
**[[3hil]] - hEPHR A1 SAM<br /> | **[[3hil]] - hEPHR A1 SAM<br /> | ||
| - | **[[2k1k]] - hEPHR A1 transmembrane domain – NMR<BR /> | + | **[[2k1l]], [[2k1k]] - hEPHR A1 transmembrane domain – NMR<BR /> |
| - | **[[1x5a]] - hEPHR A1 fn3 domain – NMR<BR | + | **[[1x5a]] - hEPHR A1 fn3 domain – NMR<BR |
| - | *Ephrin A2 receptor | + | |
| - | **[[3hpn]], [[3c8x]] - hEPHR A2 LBD | + | *Ephrin A2 receptor; domains – LBD 28-200; ectodomain 27-435; kinase 596-900 |
| - | **[[2x10]], [[3fl7]] - hEPHR A2 ectodomain | + | |
| + | **[[3hpn]], [[3c8x]] - hEPHR A2 LBD<BR /> | ||
| + | **[[2x10]], [[3fl7]] - hEPHR A2 ectodomain<BR /> | ||
**[[2k9y]], [[2e8n]] - hEPHR A2 transmembrane domain – NMR<BR /> | **[[2k9y]], [[2e8n]] - hEPHR A2 transmembrane domain – NMR<BR /> | ||
| - | **[[1mqb]], [[4p2k]], [[4pdo]], [[4trl]], [[5ek7]], [[5i9u]] - hEPHR A2 kinase domain | + | **[[1mqb]], [[4p2k]], [[4pdo]], [[4trl]], [[5ek7]], [[5i9u]] - hEPHR A2 kinase domain<BR /> |
*''Ephrin A2 receptor binary complex''<br /> | *''Ephrin A2 receptor binary complex''<br /> | ||
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**[[3hei]], [[3czu]] - hEPHR A2 LBD + ephrin A1<BR /> | **[[3hei]], [[3czu]] - hEPHR A2 LBD + ephrin A1<BR /> | ||
**[[3mbw]] - hEPHR A2 LBD + carbohydrate-recognition domain + ephrin A1<br /> | **[[3mbw]] - hEPHR A2 LBD + carbohydrate-recognition domain + ephrin A1<br /> | ||
| + | **[[6njz]], [[6nk0]], [[6nk1]], [[6nk2]], [[6nkp]], [[6b9l]] - hEPHR A2 LBD + peptide<br /> | ||
**[[2kso]] - hEPHR A2 SAM fragment residues 945-969 + SHIP2<br /> | **[[2kso]] - hEPHR A2 SAM fragment residues 945-969 + SHIP2<br /> | ||
**[[5nz9]] - hEPHR A2 SAM fragment<br /> | **[[5nz9]] - hEPHR A2 SAM fragment<br /> | ||
**[[5i9v]], [[5i9w]], [[5njz]], [[5nk0]], [[5nk1]], [[5nk2]], [[5nk3]], [[5nk4]], [[5nk5]], [[5nk6]], [[5nk7]], [[5nk8]], [[5nk9]], [[5nka]], [[5nkb]], [[5nkc]], [[5nkd]], [[5nke]], [[5nkf]], [[5nkg]], [[5nkh]], [[5nki]] - hEPHR A2 kinase domain + inhibitor<br /> | **[[5i9v]], [[5i9w]], [[5njz]], [[5nk0]], [[5nk1]], [[5nk2]], [[5nk3]], [[5nk4]], [[5nk5]], [[5nk6]], [[5nk7]], [[5nk8]], [[5nk9]], [[5nka]], [[5nkb]], [[5nkc]], [[5nkd]], [[5nke]], [[5nkf]], [[5nkg]], [[5nkh]], [[5nki]] - hEPHR A2 kinase domain + inhibitor<br /> | ||
| + | **[[6fnf]], [[6fng]], [[6fnh]] – hEPHR A2 kinase domain + pyrimidine derivative<br /> | ||
**[[5i9x]], [[5i9y]], [[5i9z]], [[5ia0]], [[5ia1]], [[5ia2]], [[5ia3]], [[5ia4]], [[5ia5]] - hEPHR A2 kinase domain + kinase drug<br /> | **[[5i9x]], [[5i9y]], [[5i9z]], [[5ia0]], [[5ia1]], [[5ia2]], [[5ia3]], [[5ia4]], [[5ia5]] - hEPHR A2 kinase domain + kinase drug<br /> | ||
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**[[4bk4]], [[4m4p]] - hEPHR A4 ectodomain<br /> | **[[4bk4]], [[4m4p]] - hEPHR A4 ectodomain<br /> | ||
**[[2lw8]] - hEPHR A4 LBD – NMR<br /> | **[[2lw8]] - hEPHR A4 LBD – NMR<br /> | ||
| + | **[[6fnl]] – hEPHR A4 kinase domain<br /> | ||
**[[2hel]] – mEPHR A4 membrane and kinase domains – mouse<br /> | **[[2hel]] – mEPHR A4 membrane and kinase domains – mouse<br /> | ||
**[[2y6m]] – mEPHR A4 kinase domain<br /> | **[[2y6m]] – mEPHR A4 kinase domain<br /> | ||
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**[[4bk5]], [[4bka]], [[4m4r]] - hEPHR A4 ectodomain + ephrin A5 LBD<br /> | **[[4bk5]], [[4bka]], [[4m4r]] - hEPHR A4 ectodomain + ephrin A5 LBD<br /> | ||
**[[4bkf]] - hEPHR A4 ectodomain + ephrin B3 LBD<br /> | **[[4bkf]] - hEPHR A4 ectodomain + ephrin B3 LBD<br /> | ||
| + | **[[6fnm]] – hEPHR A4 kinase domain + dasatinib<br /> | ||
| + | **[[6fni]], [[6fnj]], [[6fnk]] – hEPHR A4 kinase domain + pyrimidine derivative<br /> | ||
**[[2xyu]] – mEPHR A4 kinase domain + inhibitor<br /> | **[[2xyu]] – mEPHR A4 kinase domain + inhibitor<br /> | ||
**[[2y6o]] – mEPHR A4 kinase domain + cancer drug<br /> | **[[2y6o]] – mEPHR A4 kinase domain + cancer drug<br /> | ||
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**[[2r2p]] - hEPHR A5 kinase domain<BR /> | **[[2r2p]] - hEPHR A5 kinase domain<BR /> | ||
| + | **[[4et7]] – hEPHR A5 LBD (mutant)<br /> | ||
**[[1shx]] - mEPHR A5 <br /> | **[[1shx]] - mEPHR A5 <br /> | ||
| - | **[[ | + | **[[5zrz]] – mEPHR SAM domain + SAMD5<br /> |
| + | |||
*Ephrin A7 receptor | *Ephrin A7 receptor | ||
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**[[3nru]] – hEPHR A7 LBD<BR /> | **[[3nru]] – hEPHR A7 LBD<BR /> | ||
**[[3h8m]] – hEPHR A7 SAM<BR /> | **[[3h8m]] – hEPHR A7 SAM<BR /> | ||
Revision as of 07:42, 23 June 2019
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3D Structures of ephrin receptors
Updated on 23-June-2019
References
- ↑ Pitulescu ME, Adams RH. Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev. 2010 Nov 15;24(22):2480-92. doi: 10.1101/gad.1973910. PMID:21078817 doi:http://dx.doi.org/10.1101/gad.1973910
- ↑ Genander M, Frisen J. Ephrins and Eph receptors in stem cells and cancer. Curr Opin Cell Biol. 2010 Oct;22(5):611-6. doi: 10.1016/j.ceb.2010.08.005. PMID:20810264 doi:http://dx.doi.org/10.1016/j.ceb.2010.08.005
- ↑ Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. FEBS J. 2009 Aug;276(16):4395-404. PMID:19678838 doi:http://dx.doi.org/10.1111/j.1742-4658.2009.07147.x
