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Ephrin receptor
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of ephrin receptors == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Ephrin A1 receptor | ||
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| - | **[[3kka]] - hEPHR A1 SAM+ hEPH A2 SAM – human<BR /> | ||
| - | **[[3hil]] - hEPHR A1 SAM<br /> | ||
| - | **[[2k1l]], [[2k1k]] - hEPHR A1 transmembrane domain – NMR<BR /> | ||
| - | **[[1x5a]] - hEPHR A1 fn3 domain – NMR<BR | ||
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| - | *Ephrin A2 receptor; domains – LBD 28-200; ectodomain 27-435; kinase 596-900 | ||
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| - | **[[3hpn]], [[3c8x]] - hEPHR A2 LBD<BR /> | ||
| - | **[[2x10]], [[3fl7]] - hEPHR A2 ectodomain<BR /> | ||
| - | **[[2k9y]], [[2e8n]] - hEPHR A2 transmembrane domain – NMR<BR /> | ||
| - | **[[1mqb]], [[4p2k]], [[4pdo]], [[4trl]], [[5ek7]], [[5i9u]] - hEPHR A2 kinase domain<BR /> | ||
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| - | *''Ephrin A2 receptor binary complex''<br /> | ||
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| - | **[[3mx0]], [[2x11]] - hEPHR A2 ectodomain + ephrin A5<BR /> | ||
| - | **[[3hei]], [[3czu]] - hEPHR A2 LBD + ephrin A1<BR /> | ||
| - | **[[3mbw]] - hEPHR A2 LBD + carbohydrate-recognition domain + ephrin A1<br /> | ||
| - | **[[6njz]], [[6nk0]], [[6nk1]], [[6nk2]], [[6nkp]], [[6b9l]] - hEPHR A2 LBD + peptide<br /> | ||
| - | **[[2kso]] - hEPHR A2 SAM fragment residues 945-969 + SHIP2<br /> | ||
| - | **[[5nz9]] - hEPHR A2 SAM fragment<br /> | ||
| - | **[[5i9v]], [[5i9w]], [[5njz]], [[5nk0]], [[5nk1]], [[5nk2]], [[5nk3]], [[5nk4]], [[5nk5]], [[5nk6]], [[5nk7]], [[5nk8]], [[5nk9]], [[5nka]], [[5nkb]], [[5nkc]], [[5nkd]], [[5nke]], [[5nkf]], [[5nkg]], [[5nkh]], [[5nki]] - hEPHR A2 kinase domain + inhibitor<br /> | ||
| - | **[[6fnf]], [[6fng]], [[6fnh]] – hEPHR A2 kinase domain + pyrimidine derivative<br /> | ||
| - | **[[5i9x]], [[5i9y]], [[5i9z]], [[5ia0]], [[5ia1]], [[5ia2]], [[5ia3]], [[5ia4]], [[5ia5]] - hEPHR A2 kinase domain + kinase drug<br /> | ||
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| - | *Ephrin A3 receptor | ||
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| - | **[[2qo2]], [[2qob]], [[2gsf]] - hEPHR A3 kinase domain<BR /> | ||
| - | **[[2qok]], [[2qol]], [[2qon]], [[2qoo]], [[2qod]], [[2qof]], [[2qoi]] - hEPHR A3 kinase domain (mutant) <BR /> | ||
| - | **[[3fxx]], [[3fy2]] – hEPHR A3 kinase domain + peptide substrate<BR /> | ||
| - | **[[2qoq]], [[2qo7]], [[2qo9]], [[2qoc]] - hEPHR A3 kinase domain + AMP-PNP<BR /> | ||
| - | **[[3dzq]], [[4gk2]], [[4gk3]], [[4gk4]], [[4p5q]], [[4p5z]], [[4p4c]], [[4twn]], [[4two]] - hEPHR A3 kinase domain + inhibitor<br /> | ||
| - | **[[4g2f]] - hEPHR A3 kinase domain (mutant) + inhibitor<br /> | ||
| - | **[[4l0p]] - hEPHR A3 LBD + Ephrin-A5<br /> | ||
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| - | *Ephrin A4 receptor | ||
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| - | **[[2wo1]], [[3ckh]] - hEPHR A4 LBD<BR /> | ||
| - | **[[4bk4]], [[4m4p]] - hEPHR A4 ectodomain<br /> | ||
| - | **[[2lw8]] - hEPHR A4 LBD – NMR<br /> | ||
| - | **[[6fnl]] – hEPHR A4 kinase domain<br /> | ||
| - | **[[2hel]] – mEPHR A4 membrane and kinase domains – mouse<br /> | ||
| - | **[[2y6m]] – mEPHR A4 kinase domain<br /> | ||
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| - | *''Ephrin A4 receptor binary complex''<br /> | ||
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| - | **[[2wo3]] - hEPHR A4 LBD + ephrin A2 receptor-binding domain<BR /> | ||
| - | **[[4w4z]], [[4w50]], [[5jr2]] - hEPHR A4 LBD (mutant) + peptide<br /> | ||
| - | **[[2wo2]], [[3gxu]] - hEPHR A4 LBD + ephrin B2 receptor-binding domain<br /> | ||
| - | **[[4bk5]], [[4bka]], [[4m4r]] - hEPHR A4 ectodomain + ephrin A5 LBD<br /> | ||
| - | **[[4bkf]] - hEPHR A4 ectodomain + ephrin B3 LBD<br /> | ||
| - | **[[6fnm]] – hEPHR A4 kinase domain + dasatinib<br /> | ||
| - | **[[6fni]], [[6fnj]], [[6fnk]] – hEPHR A4 kinase domain + pyrimidine derivative<br /> | ||
| - | **[[2xyu]] – mEPHR A4 kinase domain + inhibitor<br /> | ||
| - | **[[2y6o]] – mEPHR A4 kinase domain + cancer drug<br /> | ||
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| - | *Ephrin A5 receptor | ||
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| - | **[[2r2p]] - hEPHR A5 kinase domain<BR /> | ||
| - | **[[4et7]] – hEPHR A5 LBD (mutant)<br /> | ||
| - | **[[1shx]] - mEPHR A5 <br /> | ||
| - | **[[5zrz]] – mEPHR SAM domain + SAMD5<br /> | ||
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| - | *Ephrin A7 receptor | ||
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| - | **[[3nru]] – hEPHR A7 LBD<BR /> | ||
| - | **[[3h8m]] – hEPHR A7 SAM<BR /> | ||
| - | **[[2rei]] - hEPHR A7 kinase domain<BR /> | ||
| - | **[[3dko]] – hEPHR A7 kinase domain + inhibitor | ||
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| - | *Ephrin A8 receptor | ||
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| - | **[[3kul]] - hEPHR A8 kinase domain<BR /> | ||
| - | **[[1x5l]] – hEPHR A8 fn3 domain – NMR<BR /> | ||
| - | **[[1ucv]] - hEPHR A8 SAM – NMR<BR /> | ||
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| - | *Ephrin B1 receptor | ||
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| - | **[[2eao]] – hEPHR B1 SAM – NMR<BR /> | ||
| - | **[[2djs]] - hEPHR B1 fn3 domain – NMR<BR /> | ||
| - | **[[3zfx]] - hEPHR B1 kinase domain residues 602-896<br /> | ||
| - | **[[5mja]] - hEPHR B1 kinase domain + inhibitor<br /> | ||
| - | **[[5mjb]] - hEPHR B1 kinase domain (mutant) + inhibitor<br /> | ||
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| - | *Ephrin B2 receptor | ||
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| - | **[[3etp]] – hEPHR B2<BR /> | ||
| - | **[[1b4f]] - hEPHR B2 SAM<br /> | ||
| - | **[[1f0m]] – mEPHR B2 SAM<BR /> | ||
| - | **[[1iko]] - mEPHR B2 ectodomain<br /> | ||
| - | **[[2i85]] - hEPHR B2 ectodomain<br /> | ||
| - | **[[3zfm]] - hEPHR B2 kinase domain<br /> | ||
| - | **[[1sgg]] - mEPHR B2 SAM – chicken - NMR<BR /> | ||
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| - | *''Ephrin B2 receptor binary complex''<br /> | ||
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| - | **[[2vsk]], [[2vsm]] – hEPHR B2 + Viral Hemagglutinin-neuraminidase<BR /> | ||
| - | **[[2qbx]] – hEPHR B2 + peptide agonist<BR /> | ||
| - | **[[2hen]] - hEPHR B2 kinase domain + ADP<BR /> | ||
| - | **[[1shw]] - mEPHR B2 LBD + ephrin A5<BR /> | ||
| - | **[[1kgy]] - mEPHR B2 LBD + ephrin B2 extracellular domain<BR /> | ||
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| - | *Ephrin B3 receptor | ||
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| - | **[[3p1i]] – hEPHR B3 LBD<BR /> | ||
| - | **[[3zfy]] - hEPHR B3 kinase domain<br /> | ||
| - | **[[5l6o]], [[5l6p]] - hEPHR B3 kinase domain (mutant) + inhibitor<br /> | ||
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| - | *Ephrin B4 receptor | ||
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| - | **[[2qkq]] – hEPHR B4 SAM<BR /> | ||
| - | **[[2e7h]] – hEPHR B4 fn3 domain - NMR<BR /> | ||
| - | **[[2x9f]], [[2vwy]] - hEPHR B4 kinase domain (mutant) <BR /> | ||
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| - | *''Ephrin B4 receptor binary complex''<br /> | ||
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| - | **[[2vwx]], [[2vwz]], [[2vx0]], [[2vx1]], [[2vwu]], [[2vwv]], [[2vww]], [[4aw5]] – hEPHR B4 kinase domain + inhibitor <BR /> | ||
| - | **[[3zew]] - hEPHR B4 + staurosporine<br /> | ||
| - | **[[2xvd]], [[2yn8]], [[4bb4]] - hEPHR B4 kinase domain (mutant) + inhibitor<br /> | ||
| - | **[[2hle]], [[2bba]] - hEPHR B4 LBD + ephrin B2 | ||
| - | }} | ||
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== References == | == References == | ||
<references/> | <references/> | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:44, 23 June 2019
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References
- ↑ Pitulescu ME, Adams RH. Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev. 2010 Nov 15;24(22):2480-92. doi: 10.1101/gad.1973910. PMID:21078817 doi:http://dx.doi.org/10.1101/gad.1973910
- ↑ Genander M, Frisen J. Ephrins and Eph receptors in stem cells and cancer. Curr Opin Cell Biol. 2010 Oct;22(5):611-6. doi: 10.1016/j.ceb.2010.08.005. PMID:20810264 doi:http://dx.doi.org/10.1016/j.ceb.2010.08.005
- ↑ Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. FEBS J. 2009 Aug;276(16):4395-404. PMID:19678838 doi:http://dx.doi.org/10.1111/j.1742-4658.2009.07147.x
