Epoxide hydrolase
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of epoxide hydrolase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Epoxide hydrolase | ||
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| - | **[[2e3j]] – EH B – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[1qo7]], [[3g02]] – AnEH (mutant) – ''Aspergillus niger''<br /> | ||
| - | **[[2cjp]] – pEH I – potato<br /> | ||
| - | **[[3cxu]], [[4ufn]], [[4ufo]], [[4ufp]], [[4uhb]], [[4y9s]] – pEH (mutant) <br /> | ||
| - | **[[4i19]], [[4qa9]], [[5f4z]] – EH – ''Streptomyces carzinostaticus''<br /> | ||
| - | **[[4qla]] – EH – silkworm<br /> | ||
| - | **[[5cxo]] – EH – ''Streptomyces albus''<br /> | ||
| - | **[[5nfq]], [[5ng7]] – EH – metagenome<br /> | ||
| - | **[[5xmd]] – mbEH – mung bean<br /> | ||
| - | **[[5y6y]], [[5y5d]], [[5xm6]] – mbEH (mutant)<br /> | ||
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| - | *Soluble epoxide hydrolase | ||
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| - | **[[1s8o]], [[3i1y]], [[3i28]], [[3koo]], [[5ahx]], [[5fp0]] – hSEH – human<br /> | ||
| - | **[[6i5e]] – hSEH C terminal<br /> | ||
| - | **[[1cqz]] – mSEH – mouse<br /> | ||
| - | **[[4nzz]] – BmSEH – ''Bacillus megaterium''<br /> | ||
| - | **[[4inz]] – BmSEH (mutant) <br /> | ||
| - | **[[1ehy]] – SEH – ''Agrobacterium tumefaciens''<br /> | ||
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| - | *Epoxide hydrolase complex with inhibitor | ||
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| - | **[[3g0i]] – AnEH + valpromide<br /> | ||
| - | **[[3rga]] – SlEH + oxazolidinone inhibitor – ''Streptomyces lasaliensis''<br /> | ||
| - | **[[4rzm]] – SlEH + lasalocid A<br /> | ||
| - | **[[5yb5]] – mbEH (mutant) + styrene derivative<br /> | ||
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| - | *Soluble epoxide hydrolase complex with inhibitor | ||
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| - | **[[1vj5]], [[1zd2]], [[1zd3]], [[1zd4]], [[1zd5]], [[3wk4]], [[4c4x]], [[4c4y]], [[4c4z]], [[5ai5]], [[5akz]], [[5ali]], [[6aum]], [[6fr2]] – hSEH + urea derivative inhibitor<br /> | ||
| - | **[[1cr6]], [[1ek1]], [[1ek2]] – mSEH + urea derivative inhibitor<br /> | ||
| - | **[[3otq]], [[3wk7]], [[4y2j]], [[4y2s]], [[4y2v]], [[5ak4]], [[5akh]], [[5aki]], [[5alk]], [[5alq]], [[5alv]], [[5aly]] – hSEH + pyrazole inhibitor<br /> | ||
| - | **[[5akj]], [[5alf]], [[5als]] – hSEH + imidazole inhibitor<br /> | ||
| - | **[[5akk]], [[5ald]], [[5aln]], [[5alo]], [[5alw]], [[5am4]] – hSEH + indolone inhibitor<br /> | ||
| - | **[[5akx]], [[5aky]] – hSEH + indazole inhibitor<br /> | ||
| - | **[[3wk5]], [[3wk6]], [[3wk8]], [[3wk9]], [[3wkc]], [[5ai8]], [[5aic]], [[5akg]], [[5alg]] – hSEH + thiazole derivative inhibitor<br /> | ||
| - | **[[3ans]], [[3ant]] – hSEH + synthetic inhibitor<br /> | ||
| - | **[[3pdc]], [[5ale]] – hSEH catalytic domain + benzoxazole inhibitor<br /> | ||
| - | **[[4jnc]], [[5alx]] – hSEH catalytic domain + carboxamide inhibitor<br /> | ||
| - | **[[4x6x]], [[4x6y]] – hSEH catalytic domain + cyclopropane inhibitor<br /> | ||
| - | **[[4hai]], [[3wka]], [[4ocz]], [[4od0]], [[5ake]], [[5alh]], [[5am1]] – hSEH + piperidine derivative inhibitor<br /> | ||
| - | **[[4y2p]], [[4y2q]], [[5ai4]], [[5ak5]], [[5ak6]], [[5alt]], [[5am5]] – hSEH + pyridine derivative inhibitor<br /> | ||
| - | **[[4y2r]] – hSEH + piperazine derivative inhibitor<br /> | ||
| - | **[[5akl]], [[5alm]], [[5am0]] – hSEH + pyrrolidine derivative inhibitor<br /> | ||
| - | **[[4y2t]], [[5aib]] – hSEH + benzyloxy derivative inhibitor<br /> | ||
| - | **[[3wkb]] – hSEH + quinoxaline derivative inhibitor<br /> | ||
| - | **[[4y2u]], [[5ai6]], [[5alj]], [[5alr]], [[5am2]] – hSEH + quinoline derivative inhibitor<br /> | ||
| - | **[[4y2x]], [[5alu]], [[5alz]] – hSEH + adamantanyl derivative inhibitor<br /> | ||
| - | **[[4y2y]] – hSEH + etylmethyamine derivative inhibitor<br /> | ||
| - | **[[3wkd]], [[5alp]] – hSEH + morpholine derivative inhibitor<br /> | ||
| - | **[[3wke]], [[5am3]] – hSEH + carbamoyl derivative inhibitor<br /> | ||
| - | **[[4j03]] – hSEH + fulvestrant<br /> | ||
| - | **[[5ai0]] – hSEH + phenyl oxadiazolamine inhibitor<br /> | ||
| - | **[[5ai9]] – hSEH + phenol derivative inhibitor<br /> | ||
| - | **[[5aia]], [[5mwa]] – hSEH + benzoate derivative inhibitor<br /> | ||
| - | **[[5ak3]] – hSEH + indan-amine derivative inhibitor<br /> | ||
| - | **[[5all]] – hSEH + cyclohexyl methanol inhibitor<br /> | ||
| - | **[[6i5g]] – hSEH C terminal + prostaglandin derivative<br /> | ||
| - | **[[4o08]] – BmSEH + phenoxy acetamide inhibitor<br /> | ||
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| - | *Soluble epoxide hydrolase complex with product | ||
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| - | **[[4io0]] – BmSEH + naphthyloxy propane diol<br /> | ||
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| - | *Limonene-1,2-epoxide hydrolase | ||
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| - | **[[1nww]] – ReEH – ''Rhodococcus erythropolis''<br /> | ||
| - | **[[4r9k]], [[4r9l]], [[4xbx]], [[4xdw]], [[5cf1]], [[5cf2]], [[5jpp]], [[5gkw]] – ReEH (mutant)<br /> | ||
| - | **[[1nu3]] – ReEH + valpromide <br /> | ||
| - | **[[4xbt]], [[4xdv]], [[5clk]], [[5jpu]], [[5yao]] – ReEH (mutant) + hexane derivative<br /> | ||
| - | **[[4xby]], [[5ck6]], [[5yng]], [[5yqt]] – ReEH (mutant) + cyclopentene oxide<br /> | ||
| - | **[[5aif]], [[5aih]], [[5aii]] – mlEH – metagenomic library<br /> | ||
| - | **[[5aig]] – mlEH + valpromide <br /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:11, 23 June 2019
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References
- ↑ Biswal BK, Morisseau C, Garen G, Cherney MM, Garen C, Niu C, Hammock BD, James MN. The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor. J Mol Biol. 2008 Sep 12;381(4):897-912. Epub 2008 Jun 17. PMID:18585390 doi:10.1016/j.jmb.2008.06.030
- ↑ Arand M, Hallberg BM, Zou J, Bergfors T, Oesch F, van der Werf MJ, de Bont JA, Jones TA, Mowbray SL. Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site. EMBO J. 2003 Jun 2;22(11):2583-92. PMID:12773375 doi:http://dx.doi.org/10.1093/emboj/cdg275
- ↑ Imig JD, Hammock BD. Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. Nat Rev Drug Discov. 2009 Oct;8(10):794-805. doi: 10.1038/nrd2875. PMID:19794443 doi:http://dx.doi.org/10.1038/nrd2875
- ↑ Oster L, Tapani S, Xue Y, Kack H. Successful generation of structural information for fragment-based drug discovery. Drug Discov Today. 2015 Apr 28. pii: S1359-6446(15)00154-3. doi:, 10.1016/j.drudis.2015.04.005. PMID:25931264 doi:http://dx.doi.org/10.1016/j.drudis.2015.04.005
