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Eukaryotic initiation factor

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Line 65: Line 65:
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
**[[2nlw]] - hEIF3B RNA recognition domain – NMR<BR />
**[[2nlw]] - hEIF3B RNA recognition domain – NMR<BR />
-
 
+
**[[2krb]] - hEIF3B RNA recognition domain + hEIF3J peptide<br />
 +
**[[5k1h]] – hEIF3B + EIF3A C-terminal<br />
 +
**[[5a5u]] - rEIF3B + rEIF3I – Cryo EM<br />
**[[3ns5]], [[3ns6]] - yEIF3B RNA recognition domain<BR />
**[[3ns5]], [[3ns6]] - yEIF3B RNA recognition domain<BR />
**[[4u1f]] - yEIF3B middle domain<br />
**[[4u1f]] - yEIF3B middle domain<br />
 +
**[[4u1e]] - yEIF3B CTD + yEIF3I + yEIF3G NTD<br />
 +
**[[4nox]] – CtEIF3B – ''Chaetomium thermophilum''<br />
**[[5h7u]] - yEIF3C residues 36-163<br />
**[[5h7u]] - yEIF3C residues 36-163<br />
-
**[[2krb]] - hEIF3B RNA recognition domain + hEIF3J peptide<br />
 
-
**[[5k1h]] – hEIF3B + EIF3A C-terminal<br />
 
**[[5krb]], [[5krc]], [[5krd]], [[5k4d]], [[5k4c]], [[5k4b]] – EIF3D – wasp<br />
**[[5krb]], [[5krc]], [[5krd]], [[5k4d]], [[5k4c]], [[5k4b]] – EIF3D – wasp<br />
**[[2cq0]] – hEIF3G RNA recognition domain – NMR<BR />
**[[2cq0]] – hEIF3G RNA recognition domain – NMR<BR />
Line 76: Line 78:
**[[5k0y]] - rEIF3G in ribosome – cryo EM<br />
**[[5k0y]] - rEIF3G in ribosome – cryo EM<br />
**[[3zwl]] - yEIF3I + EIF3B CTD<BR />
**[[3zwl]] - yEIF3I + EIF3B CTD<BR />
-
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
 
-
**[[4u1e]] - yEIF3B CTD + yEIF3I + yEIF3G NTD<br />
 
-
**[[5a5u]] - rEIF3B + rEIF3I – Cryo EM<br />
 
**[[3bpj]] – hEIF3J<BR />
**[[3bpj]] – hEIF3J<BR />
**[[1rz4]] – hEIF3K<br />
**[[1rz4]] – hEIF3K<br />
-
**[[4nox]] – CtEIF3B – ''Chaetomium thermophilum''<br />
 
*EIF4
*EIF4
 +
**[[2g9n]], [[3bor]] – hEIF4A DEAD domain<BR />
**[[1fuk]] – yEIF4A CTD<BR />
**[[1fuk]] – yEIF4A CTD<BR />
**[[1fuu]] - yEIF4A mRNA helicase domain<BR />
**[[1fuu]] - yEIF4A mRNA helicase domain<BR />
-
**[[2g9n]], [[3bor]] – hEIF4A DEAD domain<BR />
 
**[[1wi8]], [[2j76]] – hEIF4B RNA recognition domain - NMR<BR />
**[[1wi8]], [[2j76]] – hEIF4B RNA recognition domain - NMR<BR />
**[[2gpq]], [[3tf2]] – hEIF4E<BR />
**[[2gpq]], [[3tf2]] – hEIF4E<BR />
Line 94: Line 92:
**[[5me7]] - mmEIF4E - muskmelon<br />
**[[5me7]] - mmEIF4E - muskmelon<br />
**[[2idr]] – wEIF4E – wheat<BR />
**[[2idr]] – wEIF4E – wheat<BR />
-
**[[3l6a]] - hEIF4GII CTD<BR />
 
**[[1ug3]] – hEIF4GI CTD (mutant)<br />
**[[1ug3]] – hEIF4GI CTD (mutant)<br />
 +
**[[3l6a]] - hEIF4GII CTD<BR />
**[[1hu3]], [[3d3m]], [[4iul]] – hEIF4GII middle domain<br />
**[[1hu3]], [[3d3m]], [[4iul]] – hEIF4GII middle domain<br />
**[[2dng]] – hEIF4H RNA recognition domain – NMR<br />
**[[2dng]] – hEIF4H RNA recognition domain – NMR<br />
-
*EIF4 complexes
+
*EIF4 complexes with protein
-
**[[3ex7]], [[2xb2]] – hEIF4A + MAGO homolog + RNA-binding protein 8A + CASC3 + RNA<BR />
+
**[[3ex7]], [[2xb2]] – hEIF4A + MAGO homolog + RNA-binding protein 8A + CASC3 + RNA<br />
-
**[[2zu6]], [[3eiq]] – hEIF4A + programmed cell death protein<BR />
+
**[[2zu6]], [[3eiq]] – hEIF4A + programmed cell death protein<br />
**[[4c9b]] - hEIF4A + CWC22<br />
**[[4c9b]] - hEIF4A + CWC22<br />
-
**[[5mqf]] - hEIF4A in splicesome – Cryo EM<br />
+
**[[5zbz]] - hEIF4A-I DEAD domain + sanguinarine<br />
-
**[[5ekv]] - hEIF4E + 4E-BP1 peptide + inhibitor<br />
+
**[[5xln]] - hEIF4A-II + ThrRS<br />
-
**[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br />
+
**[[5mqf]], [[6icz]] - hEIF4A in splicesome – Cryo EM<br />
-
**[[4tpw]], [[4tqb]], [[4tqc]] - hEIF4E + nucleotide + inhibitor<br />
+
-
**[[4bea]] - hEIF4E + stapled peptide<br />
+
**[[5t46]] - hEIF4E + EIF4GI<br />
**[[5t46]] - hEIF4E + EIF4GI<br />
**[[5nvn]] - hEIF4E + EIF4E-binding protein<br />
**[[5nvn]] - hEIF4E + EIF4E-binding protein<br />
**[[5nvm]], [[5nvl]], [[5nvk]] - hEIF4E + GRB10-interacting GYF protein<br />
**[[5nvm]], [[5nvl]], [[5nvk]] - hEIF4E + GRB10-interacting GYF protein<br />
**[[5ehc]], [[5ei3]], [[5eir]] - hEIF4E + EIF4GI + inhibitor<br />
**[[5ehc]], [[5ei3]], [[5eir]] - hEIF4E + EIF4GI + inhibitor<br />
 +
**[[2vso]], [[2vsx]] - yEIF4E + yEIF4F<br />
 +
**[[6fc3]] - yEIF4E + p20<br />
 +
**[[6fc2]], [[6fc1]] - yEIF4E + EAP1<br />
 +
**[[4axg]] - DmEIF4E + protein CUP – Drosophila melanogaster<br />
 +
**[[4ue8]], [[4uea]], [[4ueb]], [[4ued]], [[5abu]], [[5abv]] - DmEIF4E + 4E-binding protein <br />
 +
**[[4ue9]] - DmEIF4E + 4E transporter <br />
 +
**[[4uec]], [[5t47]], [[5t48]] - DmEIF4E + DmEIF4G <br />
 +
**[[5me5]] - mmEIF4E + EIF4GI<br />
 +
**[[6fc0]], [[6fbz]] - CtEIF4G + EIF4E-like<br />
 +
 +
*EIF4 complexes with other molecules
 +
 +
**[[5zc9]] - hEIF4A-I + RNA + ATP analog + drug<br />
 +
**[[5ekv]] - hEIF4E + 4E-BP1 peptide + inhibitor<br />
 +
**[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br />
 +
**[[4tpw]], [[4tqb]], [[4tqc]] - hEIF4E + nucleotide + inhibitor<br />
 +
**[[4bea]], [[5zml]], [[5zk9]], [[5zk7]], [[5zk5]], [[5zjz]], [[5zjy]] - hEIF4E + stapled peptide<br />
**[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide - mouse<br />
**[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide - mouse<br />
-
**[[2idv]] - wEIF4E (mutant) + GDP<BR />
 
**[[1ipb]], [[1ipc]] - hEIF4E + nucleotide<br />
**[[1ipb]], [[1ipc]] - hEIF4E + nucleotide<br />
**[[4dt6]], [[4dum]] – hEIF4E + inhibitor<BR />
**[[4dt6]], [[4dum]] – hEIF4E + inhibitor<BR />
Line 123: Line 135:
**[[5osx]], [[5m84]], [[5m83]], [[5m81]], [[5m80]], [[5m7z]], [[5m7x]], [[5m7w]], [[5m7v]], [[5j5y]], [[5j5o]] - mEIF4E + mRNA cap analog<br />
**[[5osx]], [[5m84]], [[5m83]], [[5m81]], [[5m80]], [[5m7z]], [[5m7x]], [[5m7w]], [[5m7v]], [[5j5y]], [[5j5o]] - mEIF4E + mRNA cap analog<br />
**[[5bxv]], [[1ejh]] - mEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[5bxv]], [[1ejh]] - mEIF4E + nucleotide + 4E-BP1 peptide<br />
 +
**[[2idv]] - wEIF4E (mutant) + GDP<BR />
**[[3hxg]], [[3hxi]] - EIF4E + EIF4E-BP1 peptide + GDP – ''Schistosoma mansoni''<BR />
**[[3hxg]], [[3hxi]] - EIF4E + EIF4E-BP1 peptide + GDP – ''Schistosoma mansoni''<BR />
**[[3m93]], [[3m94]] - EIF4E + EIF4E-BP1 peptide + nucleotide – Pig roundworm<BR />
**[[3m93]], [[3m94]] - EIF4E + EIF4E-BP1 peptide + nucleotide – Pig roundworm<BR />
Line 128: Line 141:
**[[1ap8]] – yEIF4E + GDP – NMR<BR />
**[[1ap8]] – yEIF4E + GDP – NMR<BR />
**[[1rf8]] - yEIF4E + yEIF4GI peptide + GDP<BR />
**[[1rf8]] - yEIF4E + yEIF4GI peptide + GDP<BR />
-
**[[2vso]], [[2vsx]] - yEIF4E + yEIF4F<BR />
 
-
**[[4axg]] - DmEIF4E + protein CUP – ''Drosophila melanogaster''<br />
 
**[[4ue8]], [[4uea]], [[4ueb]], [[4ued]], [[5abu]], [[5abv]] - DmEIF4E + 4E-BP1 <br />
**[[4ue8]], [[4uea]], [[4ueb]], [[4ued]], [[5abu]], [[5abv]] - DmEIF4E + 4E-BP1 <br />
-
**[[4ue9]] - DmEIF4E + 4E transporter <br />
 
-
**[[4uec]], [[5t47]], [[5t48]] - DmEIF4E + DmEIF4G <br />
 
**[[5me6]] - mmEIF4E + GDP derivative<br />
**[[5me6]] - mmEIF4E + GDP derivative<br />
-
**[[5me5]] - mmEIF4E + EIF4GI<br />
 
*EIF5
*EIF5
-
**[[1eif]], [[2eif]] – EIF5A – ''Methanocaldococcus janaschii''<br />
 
-
**[[1x6o]] – EIF5A – ''Leishmania braziliensis''<br />
 
-
**[[1xtd]] - EIF5A – ''Leishmania mexicana''<br />
 
-
**[[3hks]] – EIF5A – ''Arabidopsis thaliana''<br />
 
-
**[[5hy6]] – EIF5A – armywarm<br />
 
**[[3cpf]] - hEIF<br />
**[[3cpf]] - hEIF<br />
-
**[[2ful]] – yEIF5 CTD<br />
 
**[[2iu1]] - hEIF5 CTD<br />
**[[2iu1]] - hEIF5 CTD<br />
**[[2g2k]] – hEIF5 NTD (mutant) – NMR<br />
**[[2g2k]] – hEIF5 NTD (mutant) – NMR<br />
Line 150: Line 152:
**[[3cpf]] – hEIF5A<br />
**[[3cpf]] – hEIF5A<br />
**[[5dlq]] – hEIF5A + exportin 4 + GTPase RAN + GTP<br />
**[[5dlq]] – hEIF5A + exportin 4 + GTPase RAN + GTP<br />
 +
**[[2ful]] – yEIF5 CTD<br />
**[[3er0]] - yEIF5A<br />
**[[3er0]] - yEIF5A<br />
 +
**[[6q84]] – yEIF5A + importin + RANGTP<br />
 +
**[[5hy6]] – EIF5A – armyworm<br />
 +
**[[1eif]], [[2eif]] – EIF5A – ''Methanocaldococcus janaschii''<br />
 +
**[[1x6o]] – EIF5A – ''Leishmania braziliensis''<br />
 +
**[[1xtd]] - EIF5A – ''Leishmania mexicana''<br />
 +
**[[3hks]] – EIF5A – ''Arabidopsis thaliana''<br />
**[[3wbi]], [[3wbj]], [[4n3s]] – yEIF5B<br />
**[[3wbi]], [[3wbj]], [[4n3s]] – yEIF5B<br />
**[[3wbk]] – yEIF5B + yEIF1A<br />
**[[3wbk]] – yEIF5B + yEIF1A<br />
Line 162: Line 171:
**[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br />
**[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br />
**[[5m3q]] – CtEIF6 <br />
**[[5m3q]] – CtEIF6 <br />
-
**[[5anb]], [[5an9]] – EIF6 in 60S ribosome – slime mold – cryo EM<br />
+
**[[5anb]], [[5an9]], [[6qkl]] – EIF6 in 60S ribosome – slime mold – cryo EM<br />
 +
**[[6em5]], [[6em4]], [[6c0f]], [[5z3g]] – yEIF6 in 60S ribosome – cryo EM<br />
 +
 
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:57, 24 June 2019

Human initiation factor EIF4E complex with 7-methyl GPPPA 1ipb

Drag the structure with the mouse to rotate

3D structures of eukaryotic initiation factor

Updated on 24-June-2019

References

  1. ↑ Jivotovskaya AV, Valasek L, Hinnebusch AG, Nielsen KH. Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast. Mol Cell Biol. 2006 Feb;26(4):1355-72. PMID:16449648 doi:http://dx.doi.org/10.1128/MCB.26.4.1355-1372.2006
  2. ↑ Hershey JW. The role of eIF3 and its individual subunits in cancer. Biochim Biophys Acta. 2015 Jul;1849(7):792-800. doi:, 10.1016/j.bbagrm.2014.10.005. Epub 2014 Nov 1. PMID:25450521 doi:http://dx.doi.org/10.1016/j.bbagrm.2014.10.005

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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