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Eukaryotic initiation factor
From Proteopedia
(Difference between revisions)
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of eukaryotic initiation factor== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *EIF1 | ||
| - | |||
| - | **[[2if1]], [[1d7q]] – hEIF1 – human – NMR<BR /> | ||
| - | **[[2ogh]] - yEIF1 – yeast - NMR<BR /> | ||
| - | **[[3j80]], [[3j81]], [[4uer]] – EIF1A in 40S ribosome – ''Kluyveromyces lactis'' – cryo EM<br /> | ||
| - | **[[4kzx]], [[4kzy]], [[4kzz]] – rEIF1A in 40S ribosome – rabbit – cryo EM<br /> | ||
| - | **[[3zjy]] – hEIF1A + importin 13 + RanGTP<br /> | ||
| - | |||
| - | *EIF2 | ||
| - | |||
| - | **[[1kl9]], [[1q8k]], [[5oa9]] – hEIF2A subunit 1<BR /> | ||
| - | **[[1q8x]] – hEIF2A - NMR<BR /> | ||
| - | **[[3ecs]] – hEIF2B<br /> | ||
| - | **[[6ezo]] – hEIF2B + drug <br /> | ||
| - | **[[6o9z]], [[6o85]], [[6o81]], [[6jlx]], [[6jlw]], [[6i7t]] – hEIF2B + hEIF2 – Cryo EM <br /> | ||
| - | **[[5w2f]] – hEIF2D C-terminal <br /> | ||
| - | **[[5oa3]] – hEIF2D in 40S ribosome – Cryo EM <br /> | ||
| - | **[[1q46]] – yEIF2A – yeast<BR /> | ||
| - | **[[3wj9]] - EIF2A – fission yeast<br /> | ||
| - | **[[2a19]], [[2a1a]] – yEIF2A (mutant) + interferon-induced protein kinase<BR /> | ||
| - | **[[6i3m]] – yEIF2B + yEIF2 – Cryo EM <br /> | ||
| - | **[[4zgq]], [[4zgn]] – yEIF2G residues 410-527 + CDC123<br /> | ||
| - | **[[3wj9]] - fyEIF2A – fission yeast<br /> | ||
| - | **[[6jlz]], [[6jly]] - fyEIF2A + EIF2B<br /> | ||
| - | |||
| - | *EIF2C or argonaute | ||
| - | |||
| - | **[[5w6v]] – hEI2C1 + RNA + GW182<br /> | ||
| - | **[[3luk]] – hEI2C2 mid domain<br /> | ||
| - | **[[3lud]], [[3lug]], [[3luh]], [[3luj]], [[3qx8]], [[3qx9]] - hEIF2C mid domain + nucleotide<br /> | ||
| - | **[[5t7b]], [[5ki6]], [[4f3t]], [[6ra4]] – hEI2C2 + RNA<br /> | ||
| - | **[[4z4i]], [[4z4h]], [[4z4g]], [[4z4f]], [[4z4e]], [[4z4d]], [[4z4c]], [[4w5t]], [[4w5r]], [[4w5q]], [[4w5o]], [[4w5n]], [[4ola]], [[6cbd]], [[5wea]], [[5js2]], [[5js1]], [[4olb]], [[6n4o]] – hEI2C2 (mutant) + RNA<br /> | ||
| - | **[[5vm9]] – hEI2C3 + RNA<br /> | ||
| - | |||
| - | *EIF3 | ||
| - | |||
| - | **[[3j8b]], [[3j8c]] - hEIF3A + hEIF3C + hEIF3E + hEIF3F + hEIF3H + hEIF3K + hEIF3L + hEIF3M – cryo EM<br /> | ||
| - | **[[5a5t]] - rEIF3A + rEIF3C + rEIF3E + rEIF3F + rEIF3H + rEIF3K + rEIF3M – Cryo EM - rat<br />**[[4kxt]], [[4krf]], [[4kre]], [[1si2]], [[1si3]] – hEI2C1 + RNA<br /> | ||
| - | **[[4k51]], [[4u1d]] - yEIF3A PCI domain<br /> | ||
| - | **[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br /> | ||
| - | **[[2nlw]] - hEIF3B RNA recognition domain – NMR<BR /> | ||
| - | **[[2krb]] - hEIF3B RNA recognition domain + hEIF3J peptide<br /> | ||
| - | **[[5k1h]] – hEIF3B + EIF3A C-terminal<br /> | ||
| - | **[[5a5u]] - rEIF3B + rEIF3I – Cryo EM<br /> | ||
| - | **[[3ns5]], [[3ns6]] - yEIF3B RNA recognition domain<BR /> | ||
| - | **[[4u1f]] - yEIF3B middle domain<br /> | ||
| - | **[[4u1e]] - yEIF3B CTD + yEIF3I + yEIF3G NTD<br /> | ||
| - | **[[4nox]] – CtEIF3B – ''Chaetomium thermophilum''<br /> | ||
| - | **[[5h7u]] - yEIF3C residues 36-163<br /> | ||
| - | **[[5krb]], [[5krc]], [[5krd]], [[5k4d]], [[5k4c]], [[5k4b]] – EIF3D – wasp<br /> | ||
| - | **[[2cq0]] – hEIF3G RNA recognition domain – NMR<BR /> | ||
| - | **[[2mjc]] - hEIF3G residues 153-176 – NMR<br /> | ||
| - | **[[5k0y]] - rEIF3G in ribosome – cryo EM<br /> | ||
| - | **[[3zwl]] - yEIF3I + EIF3B CTD<BR /> | ||
| - | **[[3bpj]] – hEIF3J<BR /> | ||
| - | **[[1rz4]] – hEIF3K<br /> | ||
| - | |||
| - | *EIF4 | ||
| - | |||
| - | **[[2g9n]], [[3bor]] – hEIF4A DEAD domain<BR /> | ||
| - | **[[1fuk]] – yEIF4A CTD<BR /> | ||
| - | **[[1fuu]] - yEIF4A mRNA helicase domain<BR /> | ||
| - | **[[1wi8]], [[2j76]] – hEIF4B RNA recognition domain - NMR<BR /> | ||
| - | **[[2gpq]], [[3tf2]] – hEIF4E<BR /> | ||
| - | **[[5gw6]] – hEIF4E (mutant)<br /> | ||
| - | **[[2wmc]] - EIF4E - pea<BR /> | ||
| - | **[[5me7]] - mmEIF4E - muskmelon<br /> | ||
| - | **[[2idr]] – wEIF4E – wheat<BR /> | ||
| - | **[[1ug3]] – hEIF4GI CTD (mutant)<br /> | ||
| - | **[[3l6a]] - hEIF4GII CTD<BR /> | ||
| - | **[[1hu3]], [[3d3m]], [[4iul]] – hEIF4GII middle domain<br /> | ||
| - | **[[2dng]] – hEIF4H RNA recognition domain – NMR<br /> | ||
| - | |||
| - | *EIF4 complexes with protein | ||
| - | |||
| - | **[[3ex7]], [[2xb2]] – hEIF4A + MAGO homolog + RNA-binding protein 8A + CASC3 + RNA<br /> | ||
| - | **[[2zu6]], [[3eiq]] – hEIF4A + programmed cell death protein<br /> | ||
| - | **[[4c9b]] - hEIF4A + CWC22<br /> | ||
| - | **[[5zbz]] - hEIF4A-I DEAD domain + sanguinarine<br /> | ||
| - | **[[5xln]] - hEIF4A-II + ThrRS<br /> | ||
| - | **[[5mqf]], [[6icz]] - hEIF4A in splicesome – Cryo EM<br /> | ||
| - | **[[5t46]] - hEIF4E + EIF4GI<br /> | ||
| - | **[[5nvn]] - hEIF4E + EIF4E-binding protein<br /> | ||
| - | **[[5nvm]], [[5nvl]], [[5nvk]] - hEIF4E + GRB10-interacting GYF protein<br /> | ||
| - | **[[5ehc]], [[5ei3]], [[5eir]] - hEIF4E + EIF4GI + inhibitor<br /> | ||
| - | **[[2vso]], [[2vsx]] - yEIF4E + yEIF4F<br /> | ||
| - | **[[6fc3]] - yEIF4E + p20<br /> | ||
| - | **[[6fc2]], [[6fc1]] - yEIF4E + EAP1<br /> | ||
| - | **[[4axg]] - DmEIF4E + protein CUP – Drosophila melanogaster<br /> | ||
| - | **[[4ue8]], [[4uea]], [[4ueb]], [[4ued]], [[5abu]], [[5abv]] - DmEIF4E + 4E-binding protein <br /> | ||
| - | **[[4ue9]] - DmEIF4E + 4E transporter <br /> | ||
| - | **[[4uec]], [[5t47]], [[5t48]] - DmEIF4E + DmEIF4G <br /> | ||
| - | **[[5me5]] - mmEIF4E + EIF4GI<br /> | ||
| - | **[[6fc0]], [[6fbz]] - CtEIF4G + EIF4E-like<br /> | ||
| - | |||
| - | *EIF4 complexes with other molecules | ||
| - | |||
| - | **[[5zc9]] - hEIF4A-I + RNA + ATP analog + drug<br /> | ||
| - | **[[5ekv]] - hEIF4E + 4E-BP1 peptide + inhibitor<br /> | ||
| - | **[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br /> | ||
| - | **[[4tpw]], [[4tqb]], [[4tqc]] - hEIF4E + nucleotide + inhibitor<br /> | ||
| - | **[[4bea]], [[5zml]], [[5zk9]], [[5zk7]], [[5zk5]], [[5zjz]], [[5zjy]] - hEIF4E + stapled peptide<br /> | ||
| - | **[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide - mouse<br /> | ||
| - | **[[1ipb]], [[1ipc]] - hEIF4E + nucleotide<br /> | ||
| - | **[[4dt6]], [[4dum]] – hEIF4E + inhibitor<BR /> | ||
| - | **[[2w97]], [[4aza]] – hEIF4E + hEIF4G peptide<br /> | ||
| - | **[[2v8w]], [[2v8x]], [[2v8y]], [[3u7x]], [[2jgc]] - hEIF4E + EIF4E-BP1 peptide<br /> | ||
| - | **[[3am7]], [[1wkw]] - hEIF4E + EIF4E-BP1 peptide + nucleotide<br /> | ||
| - | **[[1ej4]] - mEIF4E + EIF4E-BP1 peptide<br /> | ||
| - | **[[5osx]], [[5m84]], [[5m83]], [[5m81]], [[5m80]], [[5m7z]], [[5m7x]], [[5m7w]], [[5m7v]], [[5j5y]], [[5j5o]] - mEIF4E + mRNA cap analog<br /> | ||
| - | **[[5bxv]], [[1ejh]] - mEIF4E + nucleotide + 4E-BP1 peptide<br /> | ||
| - | **[[2idv]] - wEIF4E (mutant) + GDP<BR /> | ||
| - | **[[3hxg]], [[3hxi]] - EIF4E + EIF4E-BP1 peptide + GDP – ''Schistosoma mansoni''<BR /> | ||
| - | **[[3m93]], [[3m94]] - EIF4E + EIF4E-BP1 peptide + nucleotide – Pig roundworm<BR /> | ||
| - | **[[5abx]], [[5aby]] - EIF4E + EIF4E-BP1 peptide + nucleotide – roundworm<br /> | ||
| - | **[[1ap8]] – yEIF4E + GDP – NMR<BR /> | ||
| - | **[[1rf8]] - yEIF4E + yEIF4GI peptide + GDP<BR /> | ||
| - | **[[4ue8]], [[4uea]], [[4ueb]], [[4ued]], [[5abu]], [[5abv]] - DmEIF4E + 4E-BP1 <br /> | ||
| - | **[[5me6]] - mmEIF4E + GDP derivative<br /> | ||
| - | |||
| - | *EIF5 | ||
| - | |||
| - | **[[3cpf]] - hEIF<br /> | ||
| - | **[[2iu1]] - hEIF5 CTD<br /> | ||
| - | **[[2g2k]] – hEIF5 NTD (mutant) – NMR<br /> | ||
| - | **[[2e9h]] – hEIF5 – NMR<br /> | ||
| - | **[[3cpf]] – hEIF5A<br /> | ||
| - | **[[5dlq]] – hEIF5A + exportin 4 + GTPase RAN + GTP<br /> | ||
| - | **[[2ful]] – yEIF5 CTD<br /> | ||
| - | **[[3er0]] - yEIF5A<br /> | ||
| - | **[[6q84]] – yEIF5A + importin + RANGTP<br /> | ||
| - | **[[5hy6]] – EIF5A – armyworm<br /> | ||
| - | **[[1eif]], [[2eif]] – EIF5A – ''Methanocaldococcus janaschii''<br /> | ||
| - | **[[1x6o]] – EIF5A – ''Leishmania braziliensis''<br /> | ||
| - | **[[1xtd]] - EIF5A – ''Leishmania mexicana''<br /> | ||
| - | **[[3hks]] – EIF5A – ''Arabidopsis thaliana''<br /> | ||
| - | **[[3wbi]], [[3wbj]], [[4n3s]] – yEIF5B<br /> | ||
| - | **[[3wbk]] – yEIF5B + yEIF1A<br /> | ||
| - | **[[4ncf]] – yEIF5B + nucleotide<br /> | ||
| - | **[[4tmt]], [[4tmv]], [[4tmw]], [[4tmx]], [[4tmz]], [[4tn1]] – CtEIF5B (mutant) + nucleotide<br /> | ||
| - | |||
| - | *EIF6 | ||
| - | |||
| - | **[[1g62]] – yEIF6 <br /> | ||
| - | **[[2x7n]] – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24<br /> | ||
| - | **[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br /> | ||
| - | **[[5m3q]] – CtEIF6 <br /> | ||
| - | **[[5anb]], [[5an9]], [[6qkl]] – EIF6 in 60S ribosome – slime mold – cryo EM<br /> | ||
| - | **[[6em5]], [[6em4]], [[6c0f]], [[5z3g]] – yEIF6 in 60S ribosome – cryo EM<br /> | ||
| - | |||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:59, 24 June 2019
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References
- ↑ Jivotovskaya AV, Valasek L, Hinnebusch AG, Nielsen KH. Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast. Mol Cell Biol. 2006 Feb;26(4):1355-72. PMID:16449648 doi:http://dx.doi.org/10.1128/MCB.26.4.1355-1372.2006
- ↑ Hershey JW. The role of eIF3 and its individual subunits in cancer. Biochim Biophys Acta. 2015 Jul;1849(7):792-800. doi:, 10.1016/j.bbagrm.2014.10.005. Epub 2014 Nov 1. PMID:25450521 doi:http://dx.doi.org/10.1016/j.bbagrm.2014.10.005
