6p7i
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound== | |
| - | + | <StructureSection load='6p7i' size='340' side='right'caption='[[6p7i]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6p7i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P7I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P7I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=O3P:N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]prop-2-enamide'>O3P</scene>, <scene name='pdbligand=O3S:N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]propanamide'>O3S</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_I_protein_arginine_methyltransferase Type I protein arginine methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.319 2.1.1.319] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p7i OCA], [http://pdbe.org/6p7i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p7i RCSB], [http://www.ebi.ac.uk/pdbsum/6p7i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p7i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ANM6_HUMAN ANM6_HUMAN]] Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).<ref>PMID:11724789</ref> <ref>PMID:16157300</ref> <ref>PMID:16159886</ref> <ref>PMID:16600869</ref> <ref>PMID:17267505</ref> <ref>PMID:17898714</ref> <ref>PMID:18079182</ref> <ref>PMID:18077460</ref> <ref>PMID:19405910</ref> <ref>PMID:19509293</ref> <ref>PMID:20047962</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Type I protein arginine methyltransferase]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Brown, P J]] | ||
| + | [[Category: Dong, A]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Halabelian, L]] | ||
[[Category: Hutchinson, A]] | [[Category: Hutchinson, A]] | ||
| - | [[Category: | + | [[Category: Li, Y]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
[[Category: Seitova, A]] | [[Category: Seitova, A]] | ||
| - | [[Category: Dong, A]] | ||
| - | [[Category: Structural Genomics Consortium (Sgc)]] | ||
| - | [[Category: Li, Y]] | ||
| - | [[Category: Brown, P.J]] | ||
| - | [[Category: Halabelian, L]] | ||
[[Category: Zeng, H]] | [[Category: Zeng, H]] | ||
| - | [[Category: | + | [[Category: Hrmt1l6]] |
| + | [[Category: Prmt inhibitor]] | ||
| + | [[Category: Prmt6]] | ||
| + | [[Category: Protein arginine methyltransferase]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 07:01, 26 June 2019
Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound
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Categories: Large Structures | Type I protein arginine methyltransferase | Arrowsmith, C H | Bountra, C | Brown, P J | Dong, A | Edwards, A M | Halabelian, L | Hutchinson, A | Li, Y | Structural genomic | Seitova, A | Zeng, H | Hrmt1l6 | Prmt inhibitor | Prmt6 | Protein arginine methyltransferase | Sgc | Transferase-transferase inhibitor complex
