6p9e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of IL-36gamma complexed to A-552== | |
| - | + | <StructureSection load='6p9e' size='340' side='right'caption='[[6p9e]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6p9e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P9E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O6D:(2S)-2-{[4-(3-amino-4-methylphenyl)-6-methylpyrimidin-2-yl]oxy}-3-methoxy-3,3-diphenylpropanoic+acid'>O6D</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p9e OCA], [http://pdbe.org/6p9e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p9e RCSB], [http://www.ebi.ac.uk/pdbsum/6p9e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p9e ProSAT]</span></td></tr> |
| - | [[Category: Herold, J | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/IL36G_HUMAN IL36G_HUMAN]] Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Argiriadi, M A]] | ||
| + | [[Category: Gerstein, C E]] | ||
| + | [[Category: Gopalakrishnan, S M]] | ||
| + | [[Category: Henry, R F]] | ||
| + | [[Category: Herold, J M]] | ||
| + | [[Category: Honore, P]] | ||
| + | [[Category: Kakavas, S J]] | ||
| + | [[Category: McDonald, H A]] | ||
| + | [[Category: McGaraughty, S P]] | ||
[[Category: Medina, L]] | [[Category: Medina, L]] | ||
| + | [[Category: Paulsboe, S E]] | ||
| + | [[Category: Putman, B]] | ||
| + | [[Category: Qiu, W]] | ||
| + | [[Category: Richardson, P L]] | ||
| + | [[Category: Sadhukhan, R]] | ||
| + | [[Category: Salte, K M]] | ||
| + | [[Category: Scott, V E]] | ||
| + | [[Category: Shotwell, J B]] | ||
| + | [[Category: Sielaff, B]] | ||
| + | [[Category: Stockmann, H]] | ||
[[Category: Su, Z]] | [[Category: Su, Z]] | ||
| - | [[Category: | + | [[Category: Sun, C C]] |
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[[Category: Sun, Q]] | [[Category: Sun, Q]] | ||
| - | [[Category: Sun, C.C]] | ||
[[Category: Todorovic, T]] | [[Category: Todorovic, T]] | ||
| - | [[Category: | + | [[Category: Wetter, J B]] |
| - | [[Category: | + | [[Category: Cytokine]] |
| - | [[Category: | + | [[Category: Il-36]] |
| - | [[Category: | + | [[Category: Small molecule antagonist]] |
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Revision as of 07:02, 26 June 2019
Crystal structure of IL-36gamma complexed to A-552
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Categories: Large Structures | Argiriadi, M A | Gerstein, C E | Gopalakrishnan, S M | Henry, R F | Herold, J M | Honore, P | Kakavas, S J | McDonald, H A | McGaraughty, S P | Medina, L | Paulsboe, S E | Putman, B | Qiu, W | Richardson, P L | Sadhukhan, R | Salte, K M | Scott, V E | Shotwell, J B | Sielaff, B | Stockmann, H | Su, Z | Sun, C C | Sun, Q | Todorovic, T | Wetter, J B | Cytokine | Il-36 | Small molecule antagonist
