6s07
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of formylglycine-generating enzyme at 1.04 A in complex with copper and substrate reveals an acidic pocket for binding and acti-vation of molecular oxygen.== | |
| - | + | <StructureSection load='6s07' size='340' side='right'caption='[[6s07]], [[Resolution|resolution]] 1.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6s07]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S07 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BE2:2-AMINOBENZOIC+ACID'>BE2</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formylglycine-generating_enzyme Formylglycine-generating enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.7 1.8.3.7] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s07 OCA], [http://pdbe.org/6s07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s07 RCSB], [http://www.ebi.ac.uk/pdbsum/6s07 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s07 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FGE_THECD FGE_THECD]] Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile.<ref>PMID:26403223</ref> <ref>PMID:27862795</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Formylglycine-generating enzyme]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Leisinger, F]] | ||
| + | [[Category: Miarzlou, D A]] | ||
| + | [[Category: Seebeck, F P]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Copper]] | ||
| + | [[Category: Substrate analog]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:12, 26 June 2019
Structure of formylglycine-generating enzyme at 1.04 A in complex with copper and substrate reveals an acidic pocket for binding and acti-vation of molecular oxygen.
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