Farnesyl diphosphate synthase
From Proteopedia
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FPS <scene name='48/485622/Cv/12'>active site</scene> contains <scene name='48/485622/Cv/13'>Mg+2 ions coordination sites</scene> and binds <scene name='48/485622/Cv/11'>bisphosphonate inhibitors</scene>; see also <scene name='48/485622/Cv/14'>phosphates coordination sites</scene>, (PDB code [[2opm]])<ref>PMID:19309137</ref>, water molecules are shown as red spheres. | FPS <scene name='48/485622/Cv/12'>active site</scene> contains <scene name='48/485622/Cv/13'>Mg+2 ions coordination sites</scene> and binds <scene name='48/485622/Cv/11'>bisphosphonate inhibitors</scene>; see also <scene name='48/485622/Cv/14'>phosphates coordination sites</scene>, (PDB code [[2opm]])<ref>PMID:19309137</ref>, water molecules are shown as red spheres. | ||
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| + | ==3D structures of farnesyl diphosphate synthase== | ||
| + | [[Farnesyl diphosphate synthase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of farnesyl diphosphate synthase== | ==3D structures of farnesyl diphosphate synthase== | ||
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*Farnesyl diphosphate synthase | *Farnesyl diphosphate synthase | ||
| + | **[[1zw5]], [[2f7m]], [[4xqr]], [[4xqs]], [[4xqt]] – hFPS – human<br /> | ||
**[[1fps]]– cFPS – chicken<br /> | **[[1fps]]– cFPS – chicken<br /> | ||
**[[1ubv]] – cFPS (mutant) <br /> | **[[1ubv]] – cFPS (mutant) <br /> | ||
| - | **[[1zw5]], [[2f7m]], [[4xqr]], [[4xqs]], [[4xqt]] – hFPS – human<br /> | ||
**[[1rtr]]– FPS – ''Staphylococcus aureus''<br /> | **[[1rtr]]– FPS – ''Staphylococcus aureus''<br /> | ||
**[[1yhk]] – TcFPS – ''Trypanosoma cruzi''<br /> | **[[1yhk]] – TcFPS – ''Trypanosoma cruzi''<br /> | ||
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*FPS binary complexes | *FPS binary complexes | ||
| - | **[[1yq7]], [[1yv5]], [[2f89]], [[2f8c]], [[2f92]], [[2f94]], [[2f9k]], [[2rah]], [[2opn]], [[2vf6]], [[3b7l]], [[2opm]], [[3n1v]], [[3n1w]], [[3n3l]], [[3n45]], [[3n46]], [[3n49]], [[3n5j]], [[3n6k]], [[3n5h]], [[4dem]], [[4ga3]], [[4jvj]], [[4pvx]], [[4pvy]], [[4rxa]], [[5dgn]], [[5diq]], [[5djp]], [[5djr]], [[5djv]], [[5juz]], [[5jv0]], [[5jv1]], [[5jv2]], [[5ksx]] - hFPS + inhibitor<br /> | + | **[[1yq7]], [[1yv5]], [[2f89]], [[2f8c]], [[2f92]], [[2f94]], [[2f9k]], [[2rah]], [[2opn]], [[2vf6]], [[3b7l]], [[2opm]], [[3n1v]], [[3n1w]], [[3n3l]], [[3n45]], [[3n46]], [[3n49]], [[3n5j]], [[3n6k]], [[3n5h]], [[4dem]], [[4ga3]], [[4jvj]], [[4pvx]], [[4pvy]], [[4rxa]], [[5dgn]], [[5diq]], [[5djp]], [[5djr]], [[5djv]], [[5juz]], [[5jv0]], [[5jv1]], [[5jv2]], [[5ksx]], [[5ygi]] - hFPS + inhibitor<br /> |
**[[2qis]], [[3cp6]], [[3rye]], [[3s4j]], [[4n9u]] - hFPS (mutant) + inhibitor<br /> | **[[2qis]], [[3cp6]], [[3rye]], [[3s4j]], [[4n9u]] - hFPS (mutant) + inhibitor<br /> | ||
**[[4kfa]], [[4kpj]], [[4kq5]] - hFPS (mutant) + osteoporosis drug<br /> | **[[4kfa]], [[4kpj]], [[4kq5]] - hFPS (mutant) + osteoporosis drug<br /> | ||
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**[[5dgm]], [[5dgs]] - hFPS + monophosphonate<br /> | **[[5dgm]], [[5dgs]] - hFPS + monophosphonate<br /> | ||
**[[5ja0]] - hFPS + FPP<br /> | **[[5ja0]] - hFPS + FPP<br /> | ||
| - | **[[2i19]], [[2ewg]], [[2ogd]], [[2p1c]], [[3dyg]], [[3dyh]], [[3efq]], [[3egt]] - TbFPS + inhibitor – ''Trypanosoma brucei''<br /> | ||
**[[1ubw]], [[1ubx]] - cFPS (mutant) + GDP<br /> | **[[1ubw]], [[1ubx]] - cFPS (mutant) + GDP<br /> | ||
**[[1uby]] - cFPS (mutant) + dimethylallyl PP<br /> | **[[1uby]] - cFPS (mutant) + dimethylallyl PP<br /> | ||
| + | **[[2i19]], [[2ewg]], [[2ogd]], [[2p1c]], [[3dyg]], [[3dyh]], [[3efq]], [[3egt]] - TbFPS + inhibitor – ''Trypanosoma brucei''<br /> | ||
**[[2for]]– FPS + IPP – ''Shigella flexneri''<br /> | **[[2for]]– FPS + IPP – ''Shigella flexneri''<br /> | ||
**[[3id0]]– TcFPS + inhibitor<br /> | **[[3id0]]– TcFPS + inhibitor<br /> | ||
Revision as of 08:42, 26 June 2019
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3D structures of farnesyl diphosphate synthase
Updated on 26-June-2019
References
- ↑ Schulbach MC, Mahapatra S, Macchia M, Barontini S, Papi C, Minutolo F, Bertini S, Brennan PJ, Crick DC. Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis. J Biol Chem. 2001 Apr 13;276(15):11624-30. Epub 2001 Jan 4. PMID:11152452 doi:http://dx.doi.org/10.1074/jbc.M007168200
- ↑ Das S, Edwards PA, Crockett JC, Rogers MJ. Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells. Biochim Biophys Acta. 2014 Apr 4;1841(4):569-73. doi:, 10.1016/j.bbalip.2013.12.010. Epub 2013 Dec 22. PMID:24369118 doi:http://dx.doi.org/10.1016/j.bbalip.2013.12.010
- ↑ Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, Leon A, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, Kubo T, Ochi M, Mukkamala D, Oldfield E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J Am Chem Soc. 2009 Apr 15;131(14):5153-62. PMID:19309137 doi:10.1021/ja808285e
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