Farnesyl diphosphate synthase
From Proteopedia
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| - | ==3D structures of farnesyl diphosphate synthase== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Farnesyl diphosphate synthase | ||
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| - | **[[1zw5]], [[2f7m]], [[4xqr]], [[4xqs]], [[4xqt]] – hFPS – human<br /> | ||
| - | **[[1fps]]– cFPS – chicken<br /> | ||
| - | **[[1ubv]] – cFPS (mutant) <br /> | ||
| - | **[[1rtr]]– FPS – ''Staphylococcus aureus''<br /> | ||
| - | **[[1yhk]] – TcFPS – ''Trypanosoma cruzi''<br /> | ||
| - | **[[3lvs]], [[3m0g]] – FPS – ''Rhodobacter capsulatus''<br /> | ||
| - | **[[3m9u]] – LbFPS – ''Lactobacillus brevis''<br /> | ||
| - | **[[5ayp]] – FPS – ''Geobacillus stearothermophilus''<br /> | ||
| - | **[[5hxn]] – z,z-FPS – tomato<br /> | ||
| - | **[[5hxo]] – z,z-FPS (mutant)<br /> | ||
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| - | *FPS binary complexes | ||
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| - | **[[1yq7]], [[1yv5]], [[2f89]], [[2f8c]], [[2f92]], [[2f94]], [[2f9k]], [[2rah]], [[2opn]], [[2vf6]], [[3b7l]], [[2opm]], [[3n1v]], [[3n1w]], [[3n3l]], [[3n45]], [[3n46]], [[3n49]], [[3n5j]], [[3n6k]], [[3n5h]], [[4dem]], [[4ga3]], [[4jvj]], [[4pvx]], [[4pvy]], [[4rxa]], [[5dgn]], [[5diq]], [[5djp]], [[5djr]], [[5djv]], [[5juz]], [[5jv0]], [[5jv1]], [[5jv2]], [[5ksx]], [[5ygi]] - hFPS + inhibitor<br /> | ||
| - | **[[2qis]], [[3cp6]], [[3rye]], [[3s4j]], [[4n9u]] - hFPS (mutant) + inhibitor<br /> | ||
| - | **[[4kfa]], [[4kpj]], [[4kq5]] - hFPS (mutant) + osteoporosis drug<br /> | ||
| - | **[[4lpg]], [[4lph]], [[4n1z]], [[4p0x]] - hFPS + drug<br /> | ||
| - | **[[4nfi]], [[4nfj]], [[4nfk]], [[4qxs]], [[4qpf]], [[5cg5]] - hFPS + bisphosphonate<br /> | ||
| - | **[[4ng6]], [[4nke]], [[4nkf]], [[4nua]], [[4ogu]], [[4q23]] - hFPS (mutant) + bisphosphonate<br /> | ||
| - | **[[5dgm]], [[5dgs]] - hFPS + monophosphonate<br /> | ||
| - | **[[5ja0]] - hFPS + FPP<br /> | ||
| - | **[[1ubw]], [[1ubx]] - cFPS (mutant) + GDP<br /> | ||
| - | **[[1uby]] - cFPS (mutant) + dimethylallyl PP<br /> | ||
| - | **[[2i19]], [[2ewg]], [[2ogd]], [[2p1c]], [[3dyg]], [[3dyh]], [[3efq]], [[3egt]] - TbFPS + inhibitor – ''Trypanosoma brucei''<br /> | ||
| - | **[[2for]]– FPS + IPP – ''Shigella flexneri''<br /> | ||
| - | **[[3id0]]– TcFPS + inhibitor<br /> | ||
| - | **[[3pde]] – LbFPS + IPP<br /> | ||
| - | **[[5hxp]] – z,z-FPS (mutant) + IPP<br /> | ||
| - | **[[5hxq]] – z,z-FPS (mutant) + DMSPP<br /> | ||
| - | **[[6b07]], [[6b02]], [[6b04]], [[6b06]] – FPS + inhibitor – spruce budworm moth<br /> | ||
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| - | *FPS ternary complexes | ||
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| - | **[[2f8z]], [[4h5e]] - hFPS + IPP + inhibitor<br /> | ||
| - | **[[4kpd]], [[4kqs]], [[4kqu]] - hFPS (mutant) + IPP + osteoporosis drug <br /> | ||
| - | **[[4p0v]], [[4p0w]] - hFPS + 2 drugs<br /> | ||
| - | **[[4h5c]], [[4h3c]], [[4h5d]], [[4lfv]] - hFPS + phosphate + inhibitor<br /> | ||
| - | **[[5cg6]] - hFPS + IPP + bisphosphonate<br /> | ||
| - | **[[4l2x]] - hFPS + PP + inhibitor<br /> | ||
| - | **[[1rqi]] – EcFPS + IPP + dimethylallyl S-thioloPP – ''Escherichia coli''<br /> | ||
| - | **[[1rqj]] - EcFPS + IPP + inhibitor<br /> | ||
| - | **[[1yhl]] – TcFPS + dimethylallyl PP + inhibitor<br /> | ||
| - | **[[1yhm]], [[3iba]], [[3ick]], [[3icm]], [[3icn]], [[3icz]], [[4dwb]], [[4dwg]], [[4dxj]], [[4dzw]], [[4e1e]] - TcFPS + IPP + inhibitor<br /> | ||
| - | **[[3ez3]] - PvFPS + IPP + inhibitor – ''Plasmodium vivax''<br /> | ||
| - | **[[3dyf]] - TbFPS + IPP + inhibitor<br /> | ||
| - | **[[5hxt]] – z,z-FPS (mutant) + DMSPP + IPP<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:43, 26 June 2019
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References
- ↑ Schulbach MC, Mahapatra S, Macchia M, Barontini S, Papi C, Minutolo F, Bertini S, Brennan PJ, Crick DC. Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis. J Biol Chem. 2001 Apr 13;276(15):11624-30. Epub 2001 Jan 4. PMID:11152452 doi:http://dx.doi.org/10.1074/jbc.M007168200
- ↑ Das S, Edwards PA, Crockett JC, Rogers MJ. Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells. Biochim Biophys Acta. 2014 Apr 4;1841(4):569-73. doi:, 10.1016/j.bbalip.2013.12.010. Epub 2013 Dec 22. PMID:24369118 doi:http://dx.doi.org/10.1016/j.bbalip.2013.12.010
- ↑ Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, Leon A, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, Kubo T, Ochi M, Mukkamala D, Oldfield E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J Am Chem Soc. 2009 Apr 15;131(14):5153-62. PMID:19309137 doi:10.1021/ja808285e
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