Fibroblast growth factor

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</StructureSection>
</StructureSection>
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==3D structures of fibroblast growth factor==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*FGF1
 
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**[[2afg]], [[1jqz]], [[1rg8]] – hFGF1 - human <br />
 
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**[[1jt3]], [[1jt4]], [[1jt5]], [[1jt7]], [[1jtc]], [[1k5u]], [[1k5v]], [[1m16]], [[1jy0]], [[1nzk]], [[1p63]], [[1pzz]], [[1q03]], [[1q04]], [[1yto]], [[1z2v]], [[1z4s]], [[2aqz]], [[2hw9]], [[2hwa]], [[2hwm]], [[2hz9]], [[2ntd]], [[3b9u]], [[3ba4]], [[3ba5]], [[3ba7]], [[3bad]], [[3bag]], [[3bah]], [[3bao]], [[3baq]], [[3bau]], [[3bav]], [[3bb2]], [[2q9x]], [[3crg]], [[3crh]], [[3cri]], [[3cqa]], [[3fgm]], [[3fj8]], [[3fj9]], [[3fja]], [[3fjb]], [[3fjc]], [[3fjd]], [[3fje]], [[3fjf]], [[3fjh]], [[3fji]], [[3fjj]], [[3fjk]], [[3hom]], [[3o3q]], [[4q91]], [[4q9g]], [[4q9p]], [[4qal]], [[4qbc]], [[4qbv]], [[4qc4]], [[4yol]], [[4xki]], [[4qo3]] – hFGF1 (mutant) <br />
 
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**[[1dzd]], [[2rq9]] – hFGF1 - NMR <br />
 
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**[[1dzc]] – hFGF1 (mutant) - NMR <br />
 
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**[[1bar]] – bFGF1 - bovine <br />
 
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**[[3hal]] – FGF1 - rabbit <br />
 
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**[[2j3p]] – rFGF1 - rat<br />
 
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**[[1fmm]] – FGF1 – ''Notophthalmus viridescens'' - NMR <br />
 
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*''FGF1 complex with small molecule''
 
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**[[1axm]], [[2axm]] – hFGF1 + HS <br />
 
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**[[3ud7]], [[3ud8]], [[3ud9]], [[3uda]] – hFGF1 + disaccharide <br />
 
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**[[2erm]] – hFGF1 + HS - NMR<br />
 
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**[[1rml]] – hFGF1 + naphthalene trisulphonate - NMR <br />
 
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**[[1hkn]] – hFGF1 + naphthalene trisulphonate <br />
 
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**[[2k8r]] – hFGF1 + anti-angiogenic drug - NMR<br />
 
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**[[3k1x]] – hFGF1 + vasoprotectant drug <br />
 
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**[[3jut]] – hFGF1 + inhibitor <br />
 
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**[[2ki4]], [[2ki6]] – hFGF1 + S100-A13<br />
 
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**[[1afc]] – bFGF1 + HS <br />
 
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**[[2uus]] – rFGF1 + HS <br />
 
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*''FGF1 complex with FGF receptor''
 
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**[[1e0o]] – hFGF1 (mutant) + hFGFR2 (mutant) + HS<br />
 
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**[[3oj2]], [[3ojm]], [[1djs]] – hFGF1 + hFGFR2 (mutant) <br />
 
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**[[1evt]] – hFGF1 + hFGFR1 <br />
 
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**[[3ojv]] – hFGF1 + hFGFR1 (mutant) <br />
 
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**[[1ry7]] – hFGF1 + hFGFR3<br />
 
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**[[3cu1]] – hFGF1 + hFGFR2<br />
 
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**[[4j23]] – hFGF1 + hFGFR2 + inhibitor<br />
 
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*FGF2
 
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**[[2fgf]] – hFGF2 precursor <br />
 
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**[[1fga]], [[4fgf]], [[1bas]], [[1bfg]], [[2bfh]], [[1bff]] – hFGF2 <br />
 
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**[[1wvz]], [[2k43]], [[2k4a]] – hFGF2 - NMR <br />
 
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**[[1bla]], [[1bld]] – hFGF2 (mutant) - NMR <br />
 
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**[[1bfb]], [[1bfc]] – hFGF2 + heparin <br />
 
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**[[5x1o]] – hFGF2 + inositol triphosphate <br />
 
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**[[1cvs]] – hFGF2 (mutant) + hFGFR1 (mutant) <br />
 
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**[[1fq9]] – hFGF2 (mutant) + hFGFR1 (mutant) + HS<br />
 
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**[[1ev2]] - hFGF2 (mutant) + hFGFR2 <br />
 
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**[[2m49]] - hFGF2 (mutant) + S100-B <br />
 
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**[[4oee]], [[4oef]], [[4oeg]] - hFGF2 (mutant) + disaccharide <br />
 
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*FGF4
 
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**[[1ijt]] – hFGF4 b-trefoil domain <br />
 
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*FGF7
 
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**[[1qqk]] – rFGF7 <br />
 
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**[[1qql]] – rFGF7/hFGF1 <br />
 
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*FGF8
 
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**[[2fdb]] – hFGF8b + hFGFR2 <br />
 
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*FGF9
 
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**[[1g82]], [[1ihk]] – hFGF9 <br />
 
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**[[5w59]] – hFGF9 (mutant) + hFGFR1 <br />
 
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**[[6nfj]] – hFGF9 C-terminal + klotho + nanobody <br />
 
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*FGF10
 
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**[[1nun]] – hFGF10 + hFGFR2 <br />
 
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*FGF12
 
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**[[1q1u]] – hFGF12 (mutant) <br />
 
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**[[4jq0]] – hFGF12 + calmodulin + sodium channel subunit α <br />
 
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*FGF13
 
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**[[3hbw]] – hFGF13 <br />
 
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**[[4dck]], [[4jpz]] – hFGF13 + calmodulin + sodium channel subunit α <br />
 
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*FGF18
 
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**[[4cjm]] – hFGF18 <br />
 
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*FGF19
 
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**[[1pwa]], [[2p23]] – hFGF19 <br />
 
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*FGF20
 
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**[[3f1r]] – hFGF20 <br />
 
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*FGF21
 
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**[[5vaq]] – hFGF21 C-terminal + klotho + nanobody <br />
 
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*FGF23
 
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**[[2p39]] – hFGF23 <br />
 
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**[[5w21]] – hFGF23 + klotho <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 06:48, 1 July 2019

Rat fibroblast growth factor 1 complex with heparan sulfate (PDB code 2uus)

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References

  1. ↑ Ornitz DM, Itoh N. Fibroblast growth factors. Genome Biol. 2001;2(3):REVIEWS3005. Epub 2001 Mar 9. PMID:11276432
  2. ↑ Kosaka N, Sakamoto H, Terada M, Ochiya T. Pleiotropic function of FGF-4: its role in development and stem cells. Dev Dyn. 2009 Feb;238(2):265-76. doi: 10.1002/dvdy.21699. PMID:18792115 doi:http://dx.doi.org/10.1002/dvdy.21699
  3. ↑ Han DS, Li F, Holt L, Connolly K, Hubert M, Miceli R, Okoye Z, Santiago G, Windle K, Wong E, Sartor RB. Keratinocyte growth factor-2 (FGF-10) promotes healing of experimental small intestinal ulceration in rats. Am J Physiol Gastrointest Liver Physiol. 2000 Nov;279(5):G1011-22. doi:, 10.1152/ajpgi.2000.279.5.G1011. PMID:11052999 doi:http://dx.doi.org/10.1152/ajpgi.2000.279.5.G1011
  4. ↑ Palmieri C, Roberts-Clark D, Assadi-Sabet A, Coope RC, O'Hare M, Sunters A, Hanby A, Slade MJ, Gomm JJ, Lam EW, Coombes RC. Fibroblast growth factor 7, secreted by breast fibroblasts, is an interleukin-1beta-induced paracrine growth factor for human breast cells. J Endocrinol. 2003 Apr;177(1):65-81. PMID:12697038
  5. ↑ Liu SB, Ma Z, Sun WL, Sun XW, Hong Y, Ma L, Qin C, Stratton HJ, Liu Q, Jiang JT. The role of androgen-induced growth factor (FGF8) on genital tubercle development in a hypospadiac male rat model of prenatal exposure to di-n-butyl phthalate. Toxicology. 2012 Mar 11;293(1-3):53-8. doi: 10.1016/j.tox.2011.12.010. Epub 2012 , Jan 17. PMID:22273727 doi:http://dx.doi.org/10.1016/j.tox.2011.12.010
  6. ↑ Giri D, Ropiquet F, Ittmann M. FGF9 is an autocrine and paracrine prostatic growth factor expressed by prostatic stromal cells. J Cell Physiol. 1999 Jul;180(1):53-60. doi:, 10.1002/(SICI)1097-4652(199907)180:1<53::AID-JCP6>3.0.CO;2-P. PMID:10362017 doi:<53::AID-JCP6>3.0.CO;2-P http://dx.doi.org/10.1002/(SICI)1097-4652(199907)180:1<53::AID-JCP6>3.0.CO;2-P
  7. ↑ Donjacour AA, Thomson AA, Cunha GR. FGF-10 plays an essential role in the growth of the fetal prostate. Dev Biol. 2003 Sep 1;261(1):39-54. PMID:12941620
  8. ↑ Song SH, Kim K, Jo EK, Kim YW, Kwon JS, Bae SS, Sung JH, Park SG, Kim JT, Suh W. Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth Muscle Cell Plasticity and Fate. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1928-36. doi:, 10.1161/ATVBAHA.116.308017. Epub 2016 Jul 28. PMID:27470512 doi:http://dx.doi.org/10.1161/ATVBAHA.116.308017
  9. ↑ Lu H, Shi X, Wu G, Zhu J, Song C, Zhang Q, Yang G. FGF13 regulates proliferation and differentiation of skeletal muscle by down-regulating Spry1. Cell Prolif. 2015 Oct;48(5):550-60. doi: 10.1111/cpr.12200. Epub 2015 Jul 31. PMID:26230950 doi:http://dx.doi.org/10.1111/cpr.12200
  10. ↑ Bar L, Feger M, Fajol A, Klotz LO, Zeng S, Lang F, Hocher B, Foller M. Insulin suppresses the production of fibroblast growth factor 23 (FGF23). Proc Natl Acad Sci U S A. 2018 May 29;115(22):5804-5809. doi:, 10.1073/pnas.1800160115. Epub 2018 May 14. PMID:29760049 doi:http://dx.doi.org/10.1073/pnas.1800160115
  11. ↑ Klempa I, Stelzner F. [Diagnosis, prognosis and surgical treatment of stomach and duodenal ulcers]. Lebensversicher Med. 1975 Sep;27(5):103-7. PMID:2823
  12. ↑ Turner N, Grose R. Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer. 2010 Feb;10(2):116-29. doi: 10.1038/nrc2780. PMID:20094046 doi:http://dx.doi.org/10.1038/nrc2780
  13. ↑ Friesel RE, Maciag T. Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEB J. 1995 Jul;9(10):919-25. PMID:7542215
  14. ↑ Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med. 2003;33(5):381-94. PMID:12696985
  15. ↑ Gasser E, Moutos CP, Downes M, Evans RM. FGF1 - a new weapon to control type 2 diabetes mellitus. Nat Rev Endocrinol. 2017 Oct;13(10):599-609. doi: 10.1038/nrendo.2017.78. Epub, 2017 Jun 30. PMID:28664920 doi:http://dx.doi.org/10.1038/nrendo.2017.78
  16. ↑ Meo Burt P, Xiao L, Dealy C, Fisher MC, Hurley MM. FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice. Endocrinology. 2016 Dec;157(12):4602-4614. doi: 10.1210/en.2016-1548. Epub 2016, Oct 12. PMID:27732085 doi:http://dx.doi.org/10.1210/en.2016-1548
  17. ↑ Wei W, Mok SC, Oliva E, Kim SH, Mohapatra G, Birrer MJ. FGF18 as a prognostic and therapeutic biomarker in ovarian cancer. J Clin Invest. 2013 Oct;123(10):4435-48. doi: 10.1172/JCI70625. Epub 2013 Sep 9. PMID:24018557 doi:http://dx.doi.org/10.1172/JCI70625
  18. ↑ Zhang X, Kong M, Zhang Z, Xu S, Yan F, Wei L, Zhou J. FGF19 genetic amplification as a potential therapeutic target in lung squamous cell carcinomas. Thorac Cancer. 2017 Nov;8(6):655-665. doi: 10.1111/1759-7714.12504. Epub 2017 Sep, 14. PMID:28906590 doi:http://dx.doi.org/10.1111/1759-7714.12504
  19. ↑ Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M. Dimerization effect of sucrose octasulfate on rat FGF1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt, 6):448-52. Epub 2008 May 16. PMID:18540049 doi:10.1107/S174430910801066X

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