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Fibroblast growth factor receptor

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<scene name='54/544712/Cv/2'>Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 with 2 molecules of fibroblast growth factor 1</scene> (PDB code [[1evt]]).
<scene name='54/544712/Cv/2'>Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 with 2 molecules of fibroblast growth factor 1</scene> (PDB code [[1evt]]).
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 +
==3D structures of fibroblast growth factor receptor==
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[[Fibroblast growth factor receptor 3D receptor]]
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</StructureSection>
</StructureSection>
==3D structures of fibroblast growth factor receptor==
==3D structures of fibroblast growth factor receptor==
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*''FGFR1 tyrosine kinase domain residues 458-765''
*''FGFR1 tyrosine kinase domain residues 458-765''
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**[[4uwy]], [[6mzq]] – hFGFR1 TKD - human<br />
**[[1fgk]], [[3kxx]], [[3ky2]], [[4rwi]], [[5flf]] – hFGFR1 TKD (mutant) - human <br />
**[[1fgk]], [[3kxx]], [[3ky2]], [[4rwi]], [[5flf]] – hFGFR1 TKD (mutant) - human <br />
-
**[[4uwy]] – hFGFR1 TKD <br />
+
**[[4wun]], [[5am6]], [[5ew8]], [[5o49]], [[5o4a], [[6mzw]], [[6c1o]] – hFGFR1 TKD + inhibitor <br />
-
**[[4wun]], [[5am6]], [[5ew8]], [[5o49]], [[5ora]] – hFGFR1 TKD + inhibitor <br />
+
**[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]], [[5b7v]], [[5am7]], [[4rwj]], [[4rwk]], [[4rwl]], [[4uwb]], [[4uwc]], [[4zsa]], [[5uq0]], [[5vnd]], [[5ur1]], [[6p68]], [[6p69]], [[6c18]], [[6c19]], [[6c1b]], [[6c1c]], [[5z0s]] – hFGFR1 TKD (mutant) + inhibitor <br />
-
**[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]], [[5b7v]], [[5am7]], [[4rwj]], [[4rwk]], [[4rwl]], [[4uwb]], [[4uwc]], [[4zsa]], [[5uq0]], [[5vnd]], [[5ur1]] – hFGFR1 TKD (mutant) + inhibitor <br />
+
**[[5zv2]] – hFGFR1 TKD (mutant) + anti-cancer drug<br />
**[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br />
**[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br />
**[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br />
**[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br />
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**[[4qqj]], [[4qqt]] – hFGFR4 TKD (mutant) <br />
**[[4qqj]], [[4qqt]] – hFGFR4 TKD (mutant) <br />
**[[5jkg]], [[5nwz]], [[5nud]] – hFGFR4 TKD + inhibitor<br />
**[[5jkg]], [[5nwz]], [[5nud]] – hFGFR4 TKD + inhibitor<br />
 +
**[[6jpj]], [[5xff]], [[5xfj]] – hFGFR4 TKD (mutant) + inhibitor<br />
**[[4qrc]], [[4r6v]], [[4qqc]], [[4qq5]], [[4uxq]], [[4xcu]] – hFGFR4 TKD (mutant) + irreversible inhibitor<br />
**[[4qrc]], [[4r6v]], [[4qqc]], [[4qq5]], [[4uxq]], [[4xcu]] – hFGFR4 TKD (mutant) + irreversible inhibitor<br />

Revision as of 07:54, 1 July 2019

Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 (pink and yellow) complex with fibroblast growth factor 1 (cyan and green) and sulfate (PDB code 1evt)

Drag the structure with the mouse to rotate

3D structures of fibroblast growth factor receptor

Updated on 01-July-2019 {{#tree:id=OrganizedByTopic|openlevels=0|

  • FGFR1
  • FGFR1 tyrosine kinase domain residues 458-765
  • FGFR1 ligand-binding domain D1 residues 35-208
    • 2cr3 – hFGFR1 LBD D1 - NMR
    • 2ckn – FGFR1 LBD D1 – mouse - NMR
  • FGFR1 D1 complex with FGF
    • 5w59 – hFGFR1 LBD D1 + FGF9
  • FGFR1 D2,D3 residues 142-365 complex with FGF
    • 3ojv – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human
    • 1cvs – hFGFR1 LBD D2,D3 (mutant) + hFGF2 (mutant)
    • 1evt – hFGFR1 LBD D2,D3 + hFGF1
    • 1fq9 – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS
    • 5w21 – hFGFR1 LBD D2,D3 + hFGF23 + klotho
  • FGFR2
  • FGFR2 tyrosine kinase domain
  • FGFR2 ligand-binding domain
    • 3dar, 3caf, 3euu – hFGFR2 LBD D2
    • 1wvz – hFGFR2 LBD D2 - NMR
    • 4wv1 – hFGFR2 LBD D2 + antibody
    • 4hwu – hFGFR2 LBD D1
  • FGFR2 complex with FGF
    • 1e0o – hFGFR2 (mutant) LBD D2,D3 + hFGF1 (mutant) + HS
    • 3oj2, 3ojm – hFGFR2 (mutant) LBD D2,D3 + hFGF1
    • 1djs – hFGFR2 LBD D2,D3 (mutant) + hFGF1
    • 1ev2, 1ii4, 1iil – hFGFR2 LBD D2,D3 + hFGF2 (mutant)
    • 4j23 – hFGFR2 LBD D2,D3 (mutant) + hFGF2 (mutant) + inhibitor
    • 3cu1 – hFGFR2 LBD D2 + hFGF1
    • 2fdb – hFGFR2 LBD D2,D3 + hFGF8b
    • 1nun – hFGFR2 LBD D2,D3 + hFGF10
  • FGFR3
    • 3grw – hFGFR3 LBD D2,D3 + antibody
    • 2lzl – hFGFR3 residues 357-399 – NMR
    • 4k33 – hFGFR3 kinase domain (mutant)
  • FGFR3 complex with FGF
    • 1ry7 – hFGFR3 LBD + hFGF1
  • FGFR4
  • FGFR4 tyrosine kinase domain

}}

References

  1. ↑ Coutts JC, Gallagher JT. Receptors for fibroblast growth factors. Immunol Cell Biol. 1995 Dec;73(6):584-9. PMID:8713482 doi:http://dx.doi.org/10.1038/icb.1995.92
  2. ↑ Wilkin DJ, Szabo JK, Cameron R, Henderson S, Bellus GA, Mack ML, Kaitila I, Loughlin J, Munnich A, Sykes B, Bonaventure J, Francomano CA. Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome. Am J Hum Genet. 1998 Sep;63(3):711-6. PMID:9718331 doi:http://dx.doi.org/10.1086/302000
  3. ↑ Intini D, Baldini L, Fabris S, Lombardi L, Ciceri G, Maiolo AT, Neri A. Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14). Br J Haematol. 2001 Aug;114(2):362-4. PMID:11529856
  4. ↑ Meyers GA, Orlow SJ, Munro IR, Przylepa KA, Jabs EW. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Nat Genet. 1995 Dec;11(4):462-4. PMID:7493034 doi:http://dx.doi.org/10.1038/ng1295-462

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