Fibroblast growth factor receptor
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of fibroblast growth factor receptor== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *FGFR1 | ||
| - | |||
| - | *''FGFR1 tyrosine kinase domain residues 458-765'' | ||
| - | |||
| - | **[[4uwy]], [[6mzq]] – hFGFR1 TKD - human<br /> | ||
| - | **[[1fgk]], [[3kxx]], [[3ky2]], [[4rwi]], [[5flf]] – hFGFR1 TKD (mutant) - human <br /> | ||
| - | **[[4wun]], [[5am6]], [[5ew8]], [[5o49]], [[5o4a], [[6mzw]], [[6c1o]] – hFGFR1 TKD + inhibitor <br /> | ||
| - | **[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]], [[5b7v]], [[5am7]], [[4rwj]], [[4rwk]], [[4rwl]], [[4uwb]], [[4uwc]], [[4zsa]], [[5uq0]], [[5vnd]], [[5ur1]], [[6p68]], [[6p69]], [[6c18]], [[6c19]], [[6c1b]], [[6c1c]], [[5z0s]] – hFGFR1 TKD (mutant) + inhibitor <br /> | ||
| - | **[[5zv2]] – hFGFR1 TKD (mutant) + anti-cancer drug<br /> | ||
| - | **[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br /> | ||
| - | **[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br /> | ||
| - | **[[3gqi]] – hFGFR1 TKD (mutant) with PTR + ACP <br /> | ||
| - | **[[3gql]] – hFGFR1 TKD (mutant) + substrate <br /> | ||
| - | |||
| - | *''FGFR1 ligand-binding domain D1 residues 35-208'' | ||
| - | |||
| - | **[[2cr3]] – hFGFR1 LBD D1 - NMR<br /> | ||
| - | **[[2ckn]] – FGFR1 LBD D1 – mouse - NMR<br /> | ||
| - | |||
| - | *''FGFR1 D1 complex with FGF'' | ||
| - | |||
| - | **[[5w59]] – hFGFR1 LBD D1 + FGF9<br /> | ||
| - | |||
| - | *''FGFR1 D2,D3 residues 142-365 complex with FGF'' | ||
| - | |||
| - | **[[3ojv]] – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human <br /> | ||
| - | **[[1cvs]] – hFGFR1 LBD D2,D3 (mutant) + hFGF2 (mutant) <br /> | ||
| - | **[[1evt]] – hFGFR1 LBD D2,D3 + hFGF1 <br /> | ||
| - | **[[1fq9]] – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS<br /> | ||
| - | **[[5w21]] – hFGFR1 LBD D2,D3 + hFGF23 + klotho <br /> | ||
| - | |||
| - | *FGFR2 | ||
| - | |||
| - | *''FGFR2 tyrosine kinase domain'' | ||
| - | |||
| - | **[[1gjo]], [[1oec]], [[2psq]] – hFGFR2 TKD <br /> | ||
| - | **[[2pvy]], [[2pwl]], [[2py3]], [[2pz5]], [[2pzp]], [[2pzr]], [[2q0b]], [[4j95]], [[4j96]], [[4j97]], [[4j98]], [[4j99]], [[5ugx]], [[5uhn]], [[5ui0]] – hFGFR2 TKD (mutant) + ACP<br /> | ||
| - | **[[5ugl]] – hFGFR2 TKD (mutant) + ANP<br /> | ||
| - | **[[3b2t]] – hFGFR2 TKD (mutant) + adenosine derivative<br /> | ||
| - | **[[2pvf]] – hFGFR2 TKD with PTR + ACP + substrate peptide<br /> | ||
| - | **[[3cly]] – hFGFR2 TKD (mutant) with PTR + ACP <br /> | ||
| - | **[[5eg3]] – hFGFR2 TKD (mutant) with PTR + ACP + phospholipase C γ<br /> | ||
| - | **[[3ri1]] – hFGFR2 TKD + inhibitor<br /> | ||
| - | |||
| - | *''FGFR2 ligand-binding domain'' | ||
| - | |||
| - | **[[3dar]], [[3caf]], [[3euu]] – hFGFR2 LBD D2 <br /> | ||
| - | **[[1wvz]] – hFGFR2 LBD D2 - NMR<br /> | ||
| - | **[[4wv1]] – hFGFR2 LBD D2 + antibody<br /> | ||
| - | **[[4hwu]] – hFGFR2 LBD D1 <br /> | ||
| - | |||
| - | *''FGFR2 complex with FGF'' | ||
| - | |||
| - | **[[1e0o]] – hFGFR2 (mutant) LBD D2,D3 + hFGF1 (mutant) + HS<br /> | ||
| - | **[[3oj2]], [[3ojm]] – hFGFR2 (mutant) LBD D2,D3 + hFGF1 <br /> | ||
| - | **[[1djs]] – hFGFR2 LBD D2,D3 (mutant) + hFGF1 <br /> | ||
| - | **[[1ev2]], [[1ii4]], [[1iil]] – hFGFR2 LBD D2,D3 + hFGF2 (mutant) <br /> | ||
| - | **[[4j23]] – hFGFR2 LBD D2,D3 (mutant) + hFGF2 (mutant) + inhibitor <br /> | ||
| - | **[[3cu1]] – hFGFR2 LBD D2 + hFGF1 <br /> | ||
| - | **[[2fdb]] – hFGFR2 LBD D2,D3 + hFGF8b <br /> | ||
| - | **[[1nun]] – hFGFR2 LBD D2,D3 + hFGF10 <br /> | ||
| - | |||
| - | *FGFR3 | ||
| - | |||
| - | **[[3grw]] – hFGFR3 LBD D2,D3 + antibody<br /> | ||
| - | **[[2lzl]] – hFGFR3 residues 357-399 – NMR<br /> | ||
| - | **[[4k33]] – hFGFR3 kinase domain (mutant)<br /> | ||
| - | |||
| - | *''FGFR3 complex with FGF'' | ||
| - | |||
| - | **[[1ry7]] – hFGFR3 LBD + hFGF1<br /> | ||
| - | |||
| - | *FGFR4 | ||
| - | |||
| - | *''FGFR4 tyrosine kinase domain'' | ||
| - | |||
| - | **[[4tye]], [[4tyg]], [[4tyi]], [[4tyj]] – hFGFR4 TKD <br /> | ||
| - | **[[4qqj]], [[4qqt]] – hFGFR4 TKD (mutant) <br /> | ||
| - | **[[5jkg]], [[5nwz]], [[5nud]] – hFGFR4 TKD + inhibitor<br /> | ||
| - | **[[6jpj]], [[5xff]], [[5xfj]] – hFGFR4 TKD (mutant) + inhibitor<br /> | ||
| - | **[[4qrc]], [[4r6v]], [[4qqc]], [[4qq5]], [[4uxq]], [[4xcu]] – hFGFR4 TKD (mutant) + irreversible inhibitor<br /> | ||
| - | |||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:57, 1 July 2019
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References
- ↑ Coutts JC, Gallagher JT. Receptors for fibroblast growth factors. Immunol Cell Biol. 1995 Dec;73(6):584-9. PMID:8713482 doi:http://dx.doi.org/10.1038/icb.1995.92
- ↑ Wilkin DJ, Szabo JK, Cameron R, Henderson S, Bellus GA, Mack ML, Kaitila I, Loughlin J, Munnich A, Sykes B, Bonaventure J, Francomano CA. Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome. Am J Hum Genet. 1998 Sep;63(3):711-6. PMID:9718331 doi:http://dx.doi.org/10.1086/302000
- ↑ Intini D, Baldini L, Fabris S, Lombardi L, Ciceri G, Maiolo AT, Neri A. Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14). Br J Haematol. 2001 Aug;114(2):362-4. PMID:11529856
- ↑ Meyers GA, Orlow SJ, Munro IR, Przylepa KA, Jabs EW. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Nat Genet. 1995 Dec;11(4):462-4. PMID:7493034 doi:http://dx.doi.org/10.1038/ng1295-462
