6a7a
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==AKR1C1 complexed with new inhibitor with novel scaffold== | |
| - | + | <StructureSection load='6a7a' size='340' side='right'caption='[[6a7a]], [[Resolution|resolution]] 2.37Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6a7a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A7A FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9S0:(4R)-6-amino-4-(4-hydroxy-3-methoxy-5-nitrophenyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile'>9S0</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a7a OCA], [http://pdbe.org/6a7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a7a RCSB], [http://www.ebi.ac.uk/pdbsum/6a7a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a7a ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AK1C1_HUMAN AK1C1_HUMAN]] Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.<ref>PMID:11013348</ref> <ref>PMID:8573067</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen, Y]] | ||
[[Category: Zhang, H]] | [[Category: Zhang, H]] | ||
[[Category: Zhao, Y]] | [[Category: Zhao, Y]] | ||
| - | [[Category: Chen, Y]] | ||
[[Category: Zheng, X]] | [[Category: Zheng, X]] | ||
| + | [[Category: 20-alpha-hydroxysteroid dehydrogenase]] | ||
| + | [[Category: Aldo-keto reductase family 1 member c1]] | ||
| + | [[Category: Alpha-hsd]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 05:44, 3 July 2019
AKR1C1 complexed with new inhibitor with novel scaffold
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