This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6gtu
From Proteopedia
(Difference between revisions)
m (Protected "6gtu" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with fragment J6== | |
| - | + | <StructureSection load='6gtu' size='340' side='right'caption='[[6gtu]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gtu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GTU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=45N:N-(1,3-BENZODIOXOL-5-YLMETHYL)CYCLOPENTANAMINE'>45N</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6emm|6emm]], [[6gtb|6gtb]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gtu OCA], [http://pdbe.org/6gtu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gtu RCSB], [http://www.ebi.ac.uk/pdbsum/6gtu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gtu ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN]] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bertoletti, N]] | ||
[[Category: Heine, A]] | [[Category: Heine, A]] | ||
| - | [[Category: Bertoletti, N]] | ||
[[Category: Klebe, G]] | [[Category: Klebe, G]] | ||
| + | [[Category: Marchais-Oberwinkler, S]] | ||
| + | [[Category: 17b-hsd14]] | ||
| + | [[Category: Fragment]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Soaking]] | ||
Current revision
17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with fragment J6
| |||||||||||
