6n8x
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Hsp90-alpha bound to PU-11-trans== | |
| - | + | <StructureSection load='6n8x' size='340' side='right'caption='[[6n8x]], [[Resolution|resolution]] 1.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6n8x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N8X FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KFY:9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine'>KFY</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n8x OCA], [http://pdbe.org/6n8x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n8x RCSB], [http://www.ebi.ac.uk/pdbsum/6n8x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n8x ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gewirth, D T]] | ||
| + | [[Category: Huck, J D]] | ||
| + | [[Category: Que, N L.S]] | ||
| + | [[Category: Cancer]] | ||
| + | [[Category: Chaperone]] | ||
| + | [[Category: Chaperone-chaperone inhibitor complex]] | ||
| + | [[Category: Cytosol]] | ||
| + | [[Category: Hsp90]] | ||
| + | [[Category: Inhibitor]] | ||
Revision as of 05:54, 3 July 2019
Hsp90-alpha bound to PU-11-trans
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