6ng3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6ng3 is ON HOLD until Paper Publication
+
==Crystal structure of human CD160 and HVEM complex==
-
 
+
<StructureSection load='6ng3' size='340' side='right'caption='[[6ng3]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
-
Authors: Liu, W., Bonanno, J., Almo, S.C.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6ng3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NG3 FirstGlance]. <br>
-
Description: Crystal structure of human CD160 and HVEM complex
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ng3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ng3 OCA], [http://pdbe.org/6ng3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ng3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ng3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ng3 ProSAT]</span></td></tr>
-
[[Category: Almo, S.C]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/BY55_HUMAN BY55_HUMAN]] CD160 antigen: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798). Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).[UniProtKB:O88875]<ref>PMID:11978774</ref> <ref>PMID:12486241</ref> <ref>PMID:16809620</ref> <ref>PMID:17307798</ref> <ref>PMID:18193050</ref> <ref>PMID:19109136</ref> <ref>PMID:25255144</ref> <ref>PMID:9973372</ref> CD160 antigen, soluble form: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.<ref>PMID:17237375</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Almo, S C]]
 +
[[Category: Bonanno, J]]
[[Category: Liu, W]]
[[Category: Liu, W]]
-
[[Category: Bonanno, J]]
+
[[Category: Btla]]
 +
[[Category: Cd160]]
 +
[[Category: Gd]]
 +
[[Category: Hvem]]
 +
[[Category: Immune system]]

Revision as of 05:55, 3 July 2019

Crystal structure of human CD160 and HVEM complex

PDB ID 6ng3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ng3"
Personal tools