6o3c
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8== | |
| - | + | <StructureSection load='6o3c' size='340' side='right'caption='[[6o3c]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6o3c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O3C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=LKD:3-chloro-4,7-difluoro-N-{[2-methoxy-5-(pyridin-4-yl)phenyl]methyl}-N-[trans-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide'>LKD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o3c OCA], [http://pdbe.org/6o3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o3c RCSB], [http://www.ebi.ac.uk/pdbsum/6o3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o3c ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SMO_MOUSE SMO_MOUSE]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO) (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (PubMed:25644602).[UniProtKB:Q99835]<ref>PMID:25644602</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Beachy, P A]] | ||
| + | [[Category: Deshpande, I S]] | ||
| + | [[Category: Dror, R O]] | ||
| + | [[Category: Faust, B]] | ||
| + | [[Category: Ha, B]] | ||
| + | [[Category: Hedeen, D]] | ||
| + | [[Category: Latorraca, N R]] | ||
| + | [[Category: Liang, J]] | ||
| + | [[Category: Manglik, A]] | ||
| + | [[Category: Myers, B R]] | ||
| + | [[Category: Roberts, K J]] | ||
| + | [[Category: Zhang, Y]] | ||
| + | [[Category: Cholesterol]] | ||
| + | [[Category: Gpcr]] | ||
| + | [[Category: Hedgehog]] | ||
| + | [[Category: Sag]] | ||
| + | [[Category: Signaling]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Smoothened]] | ||
Revision as of 05:56, 3 July 2019
Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8
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Categories: Large Structures | Beachy, P A | Deshpande, I S | Dror, R O | Faust, B | Ha, B | Hedeen, D | Latorraca, N R | Liang, J | Manglik, A | Myers, B R | Roberts, K J | Zhang, Y | Cholesterol | Gpcr | Hedgehog | Sag | Signaling | Signaling protein | Smoothened
