6oee
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of CagT from a cryo-EM reconstruction of a T4SS== | |
| + | <StructureSection load='6oee' size='340' side='right'caption='[[6oee]], [[Resolution|resolution]] 3.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6oee]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OEE FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oee OCA], [http://pdbe.org/6oee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oee RCSB], [http://www.ebi.ac.uk/pdbsum/6oee PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oee ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS complex, which contains three sub-complexes: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and stalk domain. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system complexes ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs. | ||
| - | + | Structure of the Helicobacter pylori Cag Type IV secretion system.,Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD Elife. 2019 Jun 18;8. pii: 47644. doi: 10.7554/eLife.47644. PMID:31210639<ref>PMID:31210639</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6oee" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Helicobacter pylori]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Campbell, A]] | ||
| + | [[Category: Chung, J M]] | ||
| + | [[Category: Cover, T L]] | ||
| + | [[Category: Frick-Cheng, A E]] | ||
| + | [[Category: Lacy, D B]] | ||
| + | [[Category: Ohi, M D]] | ||
| + | [[Category: Sawhney, N]] | ||
| + | [[Category: Sheedlo, M J]] | ||
| + | [[Category: H. pylori]] | ||
| + | [[Category: Secretion]] | ||
| + | [[Category: T4ss]] | ||
| + | [[Category: Translocase]] | ||
Revision as of 05:57, 3 July 2019
Structure of CagT from a cryo-EM reconstruction of a T4SS
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Categories: Helicobacter pylori | Large Structures | Campbell, A | Chung, J M | Cover, T L | Frick-Cheng, A E | Lacy, D B | Ohi, M D | Sawhney, N | Sheedlo, M J | H. pylori | Secretion | T4ss | Translocase
