6p3p
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Mcl-1 in complex with compound 65== | |
| - | + | <StructureSection load='6p3p' size='340' side='right'caption='[[6p3p]], [[Resolution|resolution]] 1.61Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6p3p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P3P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NQJ:methyl+N-(5-{[2-chloro-5-(trifluoromethyl)phenyl]sulfamoyl}-4-methylthiophene-2-carbonyl)-D-phenylalaninate'>NQJ</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p3p OCA], [http://pdbe.org/6p3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p3p RCSB], [http://www.ebi.ac.uk/pdbsum/6p3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p3p ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Follows, B]] | [[Category: Follows, B]] | ||
| + | [[Category: Toms, A V]] | ||
| + | [[Category: Apoptosis-apoptosis inhibitor complex]] | ||
| + | [[Category: Biaryl sulfonamide inhibitor]] | ||
| + | [[Category: Mcl-1]] | ||
Revision as of 05:59, 3 July 2019
Crystal structure of Mcl-1 in complex with compound 65
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