2j9a

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Revision as of 16:23, 5 November 2007

Image:2j9a.gif

2j9a, resolution 1.73Å

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BLLAP IN COMPLEX WITH MICROGININ FR1

Overview

Natural bioactive compounds are of general interest for pharmaceutical, research because they may serve as leads in drug development campaigns., Among them, microginins are linear peptides known to inhibit various, exopeptidases. The crystal structure of microginin FR1 from Microcystis, sp. bound to bovine lens leucine aminopeptidase was established at 1.73, Angstrom resolution. The observed binding structure could be beneficial, for the design of potent aminopeptidase inhibitors.

About this Structure

2J9A is a Single protein structure of sequence from Bos taurus and Microcystis sp. with CL, ZN, DMS, AHY and MPD as ligands. Structure known Active Site: AC1. Full crystallographic information is available from OCA.

Reference

Binding structure of the leucine aminopeptidase inhibitor microginin FR1., Kraft M, Schleberger C, Weckesser J, Schulz GE, FEBS Lett. 2006 Dec 22;580(30):6943-7. Epub 2006 Dec 4. PMID:17157838

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