Structural highlights
Function
[DBH_GEOSE] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The prokaryotic protein HU, integration host factor (IHF) from Escherichia coli, and transcription factor 1 (TF1) from bacteriophage SPO1 are closely related molecules. Biochemical results suggest that the role of these proteins is to bind and bend DNA. From the high-resolution structure of HU, we propose a model for this interaction with DNA. Crucial amino acid differences between the proteins can be rationalized in terms of their different specific functions.
A protein structural motif that bends DNA.,White SW, Appelt K, Wilson KS, Tanaka I Proteins. 1989;5(4):281-8. PMID:2508086[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ White SW, Appelt K, Wilson KS, Tanaka I. A protein structural motif that bends DNA. Proteins. 1989;5(4):281-8. PMID:2508086 doi:http://dx.doi.org/10.1002/prot.340050405
