Focal adhesion kinase
From Proteopedia
(Difference between revisions)
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FAK ATP-binding site is the <scene name='48/480805/Cv/5'>location of inhibitor binding</scene><ref>PMID:19030106</ref>. | FAK ATP-binding site is the <scene name='48/480805/Cv/5'>location of inhibitor binding</scene><ref>PMID:19030106</ref>. | ||
| + | == 3D Structures of focal adhesion kinase == | ||
| + | [[Focal adhesion kinase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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**[[1k04]], [[1k05]], [[3s9o]], [[2l6h]], [[2l6g]], [[2l6f]] – hFAK1 – human<br /> | **[[1k04]], [[1k05]], [[3s9o]], [[2l6h]], [[2l6g]], [[2l6f]] – hFAK1 – human<br /> | ||
| - | **[[1k40]] – mFAK1 – mouse<br /> | ||
| - | **[[5f28]] – mFAK1 + MEF2C<br /> | ||
**[[1ow6]], [[1ow7]] - hFAK1 + paxillin LD4 motif<br /> | **[[1ow6]], [[1ow7]] - hFAK1 + paxillin LD4 motif<br /> | ||
**[[1ow8]] - hFAK1 + paxillin LD2 motif<br /> | **[[1ow8]] - hFAK1 + paxillin LD2 motif<br /> | ||
**[[3b71]] - hFAK1 + ADP + ATP<BR /> | **[[3b71]] - hFAK1 + ADP + ATP<BR /> | ||
| + | **[[1k40]] – mFAK1 – mouse<br /> | ||
| + | **[[5f28]] – mFAK1 + MEF2C<br /> | ||
**[[1ktm]], [[1qvx]], [[1pv3]] - cFAK1 – chicken – NMR | **[[1ktm]], [[1qvx]], [[1pv3]] - cFAK1 – chicken – NMR | ||
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**[[1mp8]] - hFAK1 <br /> | **[[1mp8]] - hFAK1 <br /> | ||
| - | **[[2etm]], [[3bz3]], [[4gu9]], [[4kab]], [[4k9y]], [[4i4e]], [[4i4f]], [[4k8a]], [[4gu6]], [[4brx]], [[4ebv]], [[4ebw]], [[3pxk]], [[4q9s]] - hFAK1 + inhibitor<br /> | + | **[[2etm]], [[3bz3]], [[4gu9]], [[4kab]], [[4k9y]], [[4i4e]], [[4i4f]], [[4k8a]], [[4gu6]], [[4brx]], [[4ebv]], [[4ebw]], [[3pxk]], [[4q9s]], [[6i8z]] - hFAK1 + inhibitor<br /> |
**[[4kao]] - hFAK1 (mutant) + pyrazole derivative<br /> | **[[4kao]] - hFAK1 (mutant) + pyrazole derivative<br /> | ||
**[[2ijm]] - hFAK1 + ADP + ATP<BR /> | **[[2ijm]] - hFAK1 + ADP + ATP<BR /> | ||
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**[[2j0l]] - cFAK1 phosphorylated<br /> | **[[2j0l]] - cFAK1 phosphorylated<br /> | ||
**[[2jkk]], [[2jkm]], [[2jko]], [[2jkq]], [[4d58]] - cFAK1 + pyrimidine derivative<br /> | **[[2jkk]], [[2jkm]], [[2jko]], [[2jkq]], [[4d58]] - cFAK1 + pyrimidine derivative<br /> | ||
| - | **[[4c7t]] - cFAK1 + inhibitor<br /> | + | **[[4c7t]], [[6gcr]], [[6gcw]], [[6gcx]] - cFAK1 + inhibitor<br /> |
*''FAK1 FERM domain'' | *''FAK1 FERM domain'' | ||
| - | **[[2j0j]], [[2j0k]], [[2j0m]] - cFAK1 kinase + FERM domains<br /> | ||
| - | **[[2aeh]], [[2al6]] - cFAK1<br /> | ||
| - | **[[3zdt]] - cFAK1 (mutant)<br /> | ||
**[[4cye]] - hFAK1<br /> | **[[4cye]] - hFAK1<br /> | ||
**[[4ny0]] - hFAK1 (mutant)<br /> | **[[4ny0]] - hFAK1 (mutant)<br /> | ||
| + | **[[2j0j]], [[2j0k]], [[2j0m]] - cFAK1 kinase + FERM domains<br /> | ||
| + | **[[2aeh]], [[2al6]], [[6cb0]] - cFAK1<br /> | ||
| + | **[[3zdt]] - cFAK1 (mutant)<br /> | ||
*''FAK1 FAT domain'' | *''FAK1 FAT domain'' | ||
Revision as of 08:41, 3 July 2019
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3D Structures of focal adhesion kinase
Updated on 03-July-2019
References
- ↑ Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68. PMID:15688067 doi:http://dx.doi.org/10.1038/nrm1549
- ↑ Cabrita MA, Jones LM, Quizi JL, Sabourin LA, McKay BC, Addison CL. Focal adhesion kinase inhibitors are potent anti-angiogenic agents. Mol Oncol. 2011 Dec;5(6):517-26. doi: 10.1016/j.molonc.2011.10.004. Epub 2011 Oct, 20. PMID:22075057 doi:http://dx.doi.org/10.1016/j.molonc.2011.10.004
- ↑ Lietha D, Eck MJ. Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PLoS ONE. 2008;3(11):e3800. Epub 2008 Nov 24. PMID:19030106 doi:10.1371/journal.pone.0003800
