Fructose-1,6-bisphosphatase
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Fructose-1,6-bisphosphatase == | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *FBP | ||
| - | |||
| - | **[[5et5]], [[5et7]], [[5ldz]] - hFBP - human<br /> | ||
| - | **[[5k54]] – hFBP (mutant)<br /> | ||
| - | **[[2fbp]] - pFBP - pig<br /> | ||
| - | **[[1fj6]], [[1fj9]], [[1yxi]], [[2f3b]], [[2f3d]] - pFBP (mutant) <br /> | ||
| - | **[[1bk4]] – FBP – rabbit<br /> | ||
| - | **[[1d9q]] – peFBP – pea<br /> | ||
| - | **[[1dbz]], [[1dcu]] – peFBP (mutant)<br /> | ||
| - | **[[1spi]] - FBP - spinach<br /> | ||
| - | **[[5iz1]] - FBP - moss<br /> | ||
| - | **[[6ayy]], [[5djf]] - MtFBP – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[3bih]] - EcFBP GlpX (mutant) - ''Escherichia coli''<br /> | ||
| - | |||
| - | *FBP binary complexes with fructose-6-phosphate | ||
| - | |||
| - | **[[5et8]], [[5k56]] - hFBP + F6P<br /> | ||
| - | **[[5k55]] - hFBP (mutant) + F6P<br /> | ||
| - | **[[5l0a]] - hFBP 2 (mutant) + F6-di-P<br /> | ||
| - | **[[5fbp]] - pFBP + F6P<br /> | ||
| - | **[[1rdx]] - pFBP (mutant) + F6P<br /> | ||
| - | **[[2qvu]], [[2qvv]], [[1fpb]], [[3fbp]] - pFBP + F6-di-P<br /> | ||
| - | **[[4gwu]] - pFBP (mutant) + F6-di-P<br /> | ||
| - | **[[2r8t]] - EcFBP GlpX + F6P<br /> | ||
| - | **[[3d1r]] - EcFBP GlpX (mutant) + F6P<br /> | ||
| - | |||
| - | *FBP other binary complexes | ||
| - | |||
| - | **[[1fta]] – hFBP + AMP <br /> | ||
| - | **[[2fhy]], [[2fie]], [[2fix]], [[2jjk]], [[2vt5]], [[3a29]], [[2wbb]], [[2wbd]], [[3kbz]], [[3kc0]], [[3kc1]], [[2y5k]], [[2y5l]], [[4mjo]], [[5q00]], [[5q01]], [[5q02]], [[5q03]], [[5q04]], [[5q05]], [[5q06]], [[5q07]], [[5q08]], [[5q09]], [[5q0a]], [[5q0b]], [[5q0c]], [[5pzw]], [[5pzx]], [[5pzy]], [[5pzz]], [[5pzs]], [[5pzt]], [[5pzu]], [[5pzv]], [[5pzr]], [[5pzq]] - hFBP 1 + inhibitor<br /> | ||
| - | **[[5et6]] - hFBP 2 + AMP<br /> | ||
| - | **[[3ifa]] - hFBP 2 (mutant) + AMP<br /> | ||
| - | **[[4he0]] - hFBP 2 + phosphate<br /> | ||
| - | **[[1fpk]] – pFBP + Tl<br /> | ||
| - | **[[4fbp]] - pFBP + AMP <br /> | ||
| - | **[[1yyz]], [[1yz0]] - pFBP (mutant) + AMP<br /> | ||
| - | **[[1kz8]], [[1lev]], [[1q9d]] – pFBP + inhibitor<br /> | ||
| - | **[[1fbc]], [[1fbd]], [[1fbe]] – pFBP + anhydroglucitol-biphosphate <br /> | ||
| - | **[[1fbf]], [[1fbg]] – pFBP + anhydromannitol-biphosphate <br /> | ||
| - | **[[2gq1]] – EcFBP + sulfate <br /> | ||
| - | **[[3big]] - EcFBP GlpX (mutant) + phosphate<br /> | ||
| - | **[[5oey]] - FBP + phosphate – ''Leishmania major''<br /> | ||
| - | **[[5djk]], [[5djj]] - MtFBP + phosphate<br /> | ||
| - | **[[5djg]] - MtFBP + ADP derivative<br /> | ||
| - | |||
| - | *FBP ternary complexes | ||
| - | |||
| - | **[[3ifc]] - hFBP 2 (mutant) + AMP + F6P<br /> | ||
| - | **[[4he1]] - hFBP 2 (mutant) + phosphate + F6P<br /> | ||
| - | **[[4he2]] - hFBP 2 (mutant) + phosphite + AMP<br /> | ||
| - | **[[5zwk]] - hFBP 1 (mutant) + F6-di-P + AMP<br /> | ||
| - | **[[1fpi]], [[1fpj]], [[1fpl]] – pFBP + AMP + glucitol bisphosphate<br /> | ||
| - | **[[1cnq]] – pFBP + Zn + F6P<br /> | ||
| - | **[[1eyi]], [[1nuw]], [[1nux]], [[1nuy]], [[1nuz]], [[1nv0]], [[1nv1]], [[1nv2]], [[1nv3]] - pFBP + phosphate + F6P<br /> | ||
| - | **[[1fbp]] - pFBP + AMP + F6P<br /> | ||
| - | **[[1rdy]], [[1rdz]] - pFBP (mutant) + AMP + F6P<br /> | ||
| - | **[[4gx3]], [[4gww]], [[4gwx]], [[1fsa]] - pFBP (mutant) + phosphate + F6P<br /> | ||
| - | **[[1frp]] - pFBP + AMP + F-2,6-di-P<br /> | ||
| - | **[[1fpd]], [[1fpe]], [[1fpf]], [[1fpg]] – pFBP + anhydroglucitol-biphosphate + AMP<br /> | ||
| - | **[[2owz]] – EcFBP + citrate + F6P<br /> | ||
| - | **[[2qvr]] - EcFBP + citrate + F6-di-P<br /> | ||
| - | **[[2ox3]] - EcFBP + PEP + F6P<br /> | ||
| - | **[[6ayu]], [[6ayv]] - MtFBP (mutant) + malonate + F6P <br /> | ||
| - | **[[5dji]], [[5djh]] - MtFBP + phosphate + AMP<br /> | ||
| - | |||
| - | *FBP quaternary complexes | ||
| - | |||
| - | **[[1nv4]], [[1nv5]], [[1nv6]] - pFBP + phosphate + EDTA + F6P<br /> | ||
| - | **[[1eyj]], [[1eyk]], [[1nv7]], [[4h46]] - pFBP + phosphate + AMP + F6P<br /> | ||
| - | **[[4gbv]], [[4gbw]] - pFBP + phosphate + AMP + F6P<br /> | ||
| - | **[[4gx4]], [[4gx6]], [[4gwy]], [[4gws]], [[4gwz]], [[4kxp]] - pFBP (mutant) + phosphate + AMP + F6P<br /> | ||
| - | **[[4h45]] - pFBP (mutant) + phosphate + Zn + F6P<br /> | ||
| - | **[[1fbh]] – pFBP + α F-1,6-P + β F-1,6-P + F-1,6-bisphosphate <br /> | ||
| - | **[[2q8m]] – FBP + β glucose-6-P + β F-1,6-P + F-1,6-bisphosphate + AMP – ''Shigella boydii'' <br /> | ||
| - | |||
| - | *F26BP | ||
| - | |||
| - | **[[1c7z]] – rF26BP + phosphate + G3P - rat<br /> | ||
| - | **[[1c80]] – rF26BP + phosphate + GTP <br /> | ||
| - | **[[1c81]] – rF26BP + gluco-anhydro-deoxy-phosphonohexitol-phosphate <br /> | ||
| - | **[[1fbt]] – rF26BP (mutant) + phosphate <br /> | ||
| - | |||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 06:54, 4 July 2019
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References
- ↑ Zhang Y, Liang JY, Lipscomb WN. Structural similarities between fructose-1,6-bisphosphatase and inositol monophosphatase. Biochem Biophys Res Commun. 1993 Feb 15;190(3):1080-3. PMID:8382485
- ↑ Storey KB. Metabolic regulation in mammalian hibernation: enzyme and protein adaptations. Comp Biochem Physiol A Physiol. 1997 Dec;118(4):1115-24. PMID:9505421
- ↑ Depre C, Veitch K, Hue L. Role of fructose 2,6-bisphosphate in the control of glycolysis. Stimulation of glycogen synthesis by lactate in the isolated working rat heart. Acta Cardiol. 1993;48(1):147-64. PMID:8447185
- ↑ van Poelje PD, Potter SC, Chandramouli VC, Landau BR, Dang Q, Erion MD. Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. Diabetes. 2006 Jun;55(6):1747-54. PMID:16731838 doi:http://dx.doi.org/10.2337/db05-1443
- ↑ van Poelje PD, Potter SC, Erion MD. Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handb Exp Pharmacol. 2011;(203):279-301. doi: 10.1007/978-3-642-17214-4_12. PMID:21484576 doi:http://dx.doi.org/10.1007/978-3-642-17214-4_12
- ↑ Tsukada T, Takahashi M, Takemoto T, Kanno O, Yamane T, Kawamura S, Nishi T. Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1004-7. Epub 2009 Dec 21. PMID:20045638 doi:10.1016/j.bmcl.2009.12.056
