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Galactosidase
From Proteopedia
(Difference between revisions)
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For [[3hg2]] <scene name='3hg2/3hg2to3morph/6'>click here to see cycling morph from empty active site to substrate bound form and back</scene>.<br /> | For [[3hg2]] <scene name='3hg2/3hg2to3morph/6'>click here to see cycling morph from empty active site to substrate bound form and back</scene>.<br /> | ||
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| + | == 3D Structures of Galactosidase == | ||
| + | [[Galactosidase 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Galactosidase == | == 3D Structures of Galactosidase == | ||
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*α-Galactosidase | *α-Galactosidase | ||
| + | **[[3hg2]], [[3gxn]], [[1r46]], [[1r47]], [[3s5y]], [[3s5z]] – hAgal A - human<br /> | ||
| + | **[[3lx9]], [[3lxa]], [[3lxb]], [[3lxc]], [[3tv8]] - hAgal A (mutant) <br /> | ||
**[[3lrk]] – yAgal 1 (mutant) – yeast<br /> | **[[3lrk]] – yAgal 1 (mutant) – yeast<br /> | ||
**[[3lrl]], [[3lrm]] – yAgal 1 (mutant) + polysaccharide<br /> | **[[3lrl]], [[3lrm]] – yAgal 1 (mutant) + polysaccharide<br /> | ||
| - | **[[3lx9]], [[3lxa]], [[3lxb]], [[3lxc]], [[3tv8]] - hAgal A (mutant) – human<br /> | ||
| - | **[[3hg2]], [[3gxn]], [[1r46]], [[1r47]], [[3s5y]], [[3s5z]] – hAgal A<br /> | ||
**[[1zy9]], [[5m0x]] – TmAgal – ''Thermotoga maritima''<br /> | **[[1zy9]], [[5m0x]] – TmAgal – ''Thermotoga maritima''<br /> | ||
**[[3h53]] - hAgal B (mutant)<br /> | **[[3h53]] - hAgal B (mutant)<br /> | ||
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**[[4fnt]], [[4fnu]] – GsAgal + galactoside<br /> | **[[4fnt]], [[4fnu]] – GsAgal + galactoside<br /> | ||
**[[5e1q]] - BtAgal + Gal-Lac<br /> | **[[5e1q]] - BtAgal + Gal-Lac<br /> | ||
| - | **[[5m12]], [[5m16]], [[5m1i]] - TmAgal + sugar<br /> | + | **[[5m12]], [[5m16]], [[5m1i]], [[6gx8]], [[6gwg]], [[6gvd]] - TmAgal + sugar<br /> |
| + | **[[6gwf]], [[6gta]] - TmAgal (mutant) + sugar<br /> | ||
*β-Galactosidase | *β-Galactosidase | ||
**[[3og2]] – TrBgal – ''Trichoderma reesei''<br /> | **[[3og2]] – TrBgal – ''Trichoderma reesei''<br /> | ||
| - | + | **[[1hn1]], [[1dp0]], [[1f4a]], [[1f4h]], [[4v41]], [[4v40]], [[4ttg]] - EcBgal - Escherichia coli<br /> | |
| - | **[[1hn1]], [[1dp0]], [[1f4a]], [[1f4h]], [[4v41]], [[4v40]], [[4ttg]] - EcBgal<br /> | + | **[[3j7h]], [[6cvm]] – EcBgal – cryo EM<br /> |
| - | **[[3j7h]] – EcBgal – cryo EM<br /> | + | |
**[[3dec]], [[3d3a]], [[3bga]], [[5mt2]], [[5mui]], [[5muj]] – BtBgal<br /> | **[[3dec]], [[3d3a]], [[3bga]], [[5mt2]], [[5mui]], [[5muj]] – BtBgal<br /> | ||
| - | **[[6etz]] - ArBgal – ''Arthrobacter''<br /> | + | **[[6etz]], [[6h1p]] - ArBgal – ''Arthrobacter''<br /> |
**[[1yq2]] - ArBgal (mutant)<br /> | **[[1yq2]] - ArBgal (mutant)<br /> | ||
**[[1uwi]], [[4eam]], [[5i3d]] - SsBgal (mutant) - ''Sulfolobus solfataricus''<br /> | **[[1uwi]], [[4eam]], [[5i3d]] - SsBgal (mutant) - ''Sulfolobus solfataricus''<br /> | ||
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**[[5iaz]] - rBgal C-terminal - NMR<br /> | **[[5iaz]] - rBgal C-terminal - NMR<br /> | ||
**[[5ifp]] - Bgal – ''Aspergillus niger''<br /> | **[[5ifp]] - Bgal – ''Aspergillus niger''<br /> | ||
| + | **[[6mvh]] - Bgal – ''Roseburia hominis''<br /> | ||
*''β-Galactosidase binary complex with galactose'' | *''β-Galactosidase binary complex with galactose'' | ||
| + | **[[3thc]] - hBgal + galactose<br /> | ||
| + | **[[3wf3]] - hBgal + galactose + NAG<br /> | ||
**[[1xc6]] - PeBgal + galactose<br /> | **[[1xc6]] - PeBgal + galactose<br /> | ||
| - | **[[3w5g]] - toBgal + galactose<br /> | + | **[[3w5g]], [[6ik5]] - toBgal + galactose<br /> |
| + | **[[6ik6]], [[6ik7]], [[6ik8]] - toBgal (mutant) + galactobiose<br /> | ||
**[[1kwk]] – TtBgal + galactose<br /> | **[[1kwk]] – TtBgal + galactose<br /> | ||
**[[3ogr]] – TrBgal + galactose<br /> | **[[3ogr]] – TrBgal + galactose<br /> | ||
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**[[4iug]] - Bgal + galactose – ''Aspergillus oryzae''<br /> | **[[4iug]] - Bgal + galactose – ''Aspergillus oryzae''<br /> | ||
**[[3tty]] - BcBgal + galactose<br /> | **[[3tty]] - BcBgal + galactose<br /> | ||
| - | **[[3thc]] - hBgal + galactose<br /> | ||
| - | **[[3wf3]] - hBgal + galactose + NAG<br /> | ||
**[[4cub]] – SpBgal carbohydrate-binding module I + galactose <br /> | **[[4cub]] – SpBgal carbohydrate-binding module I + galactose <br /> | ||
**[[4cuc]] – SpBgal catalytic module (mutant) + galactose <br /> | **[[4cuc]] – SpBgal catalytic module (mutant) + galactose <br /> | ||
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*''β-Galactosidase other complexes'' | *''β-Galactosidase other complexes'' | ||
| + | **[[3thd]] – hBgal + jirimycin derivative<br /> | ||
| + | **[[3wez]] - hBgal + NOEV<br /> | ||
| + | **[[3wf0]], [[3wf1]] - hBgal + pyrimidine derivative<br /> | ||
| + | **[[3wf4]] - hBgal (mutant) + pyridine derivative<br /> | ||
| + | **[[3wf2]] - hBgal + piperidine derivative<br /> | ||
**[[3ogs]] - TrBgal + IPTG<br /> | **[[3ogs]] - TrBgal + IPTG<br /> | ||
**[[3ogv]] – TrBgal + inhibitor<br /> | **[[3ogv]] – TrBgal + inhibitor<br /> | ||
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**[[4dux]] - EcBgal (mutant) + ribose<br /> | **[[4dux]] - EcBgal (mutant) + ribose<br /> | ||
**[[4ckd]] – EcBgal + antibody<br /> | **[[4ckd]] – EcBgal + antibody<br /> | ||
| - | **[[3thd]] – hBgal + jirimycin derivative<br /> | ||
| - | **[[3wez]] - hBgal + NOEV<br /> | ||
| - | **[[3wf0]], [[3wf1]] - hBgal + pyrimidine derivative<br /> | ||
| - | **[[3wf4]] - hBgal (mutant) + pyridine derivative<br /> | ||
| - | **[[3wf2]] - hBgal + piperidine derivative<br /> | ||
**[[4cu7]] - SpBgal catalytic module + galacto-isofagomine<br /> | **[[4cu7]] - SpBgal catalytic module + galacto-isofagomine<br /> | ||
Revision as of 10:38, 8 July 2019
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3D Structures of Galactosidase
Updated on 08-July-2019
References
- ↑ Garman SC, Garboczi DN. The molecular defect leading to Fabry disease: structure of human alpha-galactosidase. J Mol Biol. 2004 Mar 19;337(2):319-35. PMID:15003450 doi:10.1016/j.jmb.2004.01.035
- ↑ Jacobson RH, Zhang XJ, DuBose RF, Matthews BW. Three-dimensional structure of beta-galactosidase from E. coli. Nature. 1994 Jun 30;369(6483):761-6. PMID:8008071 doi:http://dx.doi.org/10.1038/369761a08015589
- ↑ Kint JA. Fabry's disease: alpha-galactosidase deficiency. Science. 1970 Feb 27;167(3922):1268-9. PMID:5411915
- ↑ Morrone A, Bardelli T, Donati MA, Giorgi M, Di Rocco M, Gatti R, Parini R, Ricci R, Taddeucci G, D'Azzo A, Zammarchi E. beta-galactosidase gene mutations affecting the lysosomal enzyme and the elastin-binding protein in GM1-gangliosidosis patients with cardiac involvement. Hum Mutat. 2000;15(4):354-66. PMID:10737981 doi:<354::AID-HUMU8>3.0.CO;2-L 10.1002/(SICI)1098-1004(200004)15:4<354::AID-HUMU8>3.0.CO;2-L
- ↑ Hidaka M, Fushinobu S, Ohtsu N, Motoshima H, Matsuzawa H, Shoun H, Wakagi T. Trimeric crystal structure of the glycoside hydrolase family 42 beta-galactosidase from Thermus thermophilus A4 and the structure of its complex with galactose. J Mol Biol. 2002 Sep 6;322(1):79-91. PMID:12215416
- Created with the participation of Wayne Decatur.
