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Galectin

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The CRD is a β-sandwich long enough to bind a tetrasaccharide. A <scene name='51/516488/Cv/4'>lactose ligand is bound at the concave face of the β-sheet</scene><ref>PMID:15476813</ref>. Water molecules shown as red spheres.
The CRD is a β-sandwich long enough to bind a tetrasaccharide. A <scene name='51/516488/Cv/4'>lactose ligand is bound at the concave face of the β-sheet</scene><ref>PMID:15476813</ref>. Water molecules shown as red spheres.
 +
 +
==3D structures of galectin==
 +
[[Galectin 3D structures]]
 +
</StructureSection>
</StructureSection>
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*Galectin-1
*Galectin-1
-
**[[1slt]], [[1sla]], [[1slb]], [[1slc]] – GAL-1 + BGAL – bovine<br />
 
**[[1hlc]] – hGAL-1 + lactose – human<br />
**[[1hlc]] – hGAL-1 + lactose – human<br />
**[[3w58]], [[3w59]] – hGAL-1<br />
**[[3w58]], [[3w59]] – hGAL-1<br />
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**[[1w6o]], [[2zkn]] – hGAL-1 (mutant) + lactose<br />
**[[1w6o]], [[2zkn]] – hGAL-1 (mutant) + lactose<br />
**[[4q26]], [[4q27]], [[4xbl]] - hGAL-1 + acetyl lactosamine<br />
**[[4q26]], [[4q27]], [[4xbl]] - hGAL-1 + acetyl lactosamine<br />
 +
**[[6b94]] - hGAL-1 + lactulose<br />
**[[1w6p]] – hGAL-1 (mutant) + acetyl lactosamine<br />
**[[1w6p]] – hGAL-1 (mutant) + acetyl lactosamine<br />
**[[4y1u]], [[4y1v]], [[4y1x]], [[4y1y]], [[4y1z]], [[4y20]], [[4y22]], [[4y24]] - hGAL-1 N-terminal + Gal-GlcNac<br />
**[[4y1u]], [[4y1v]], [[4y1x]], [[4y1y]], [[4y1z]], [[4y20]], [[4y22]], [[4y24]] - hGAL-1 N-terminal + Gal-GlcNac<br />
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**[[3oy8]] – hGAL-1 + lactobionic acid<br />
**[[3oy8]] – hGAL-1 + lactobionic acid<br />
**[[3oyw]] - hGAL-1 + thio-digalactoside<br />
**[[3oyw]] - hGAL-1 + thio-digalactoside<br />
-
**[[3t2t]], [[4q1p]], [[4q1r]], [[4q2f]] – hGAL-1 + inhibitor<br />
+
**[[3t2t]], [[4q1p]], [[4q1r]], [[4q2f]], [[6f83]] – hGAL-1 + inhibitor<br />
**[[5mwt]], [[5mwx]] – hGAL-1 + ligand<br />
**[[5mwt]], [[5mwx]] – hGAL-1 + ligand<br />
 +
**[[1slt]], [[1sla]], [[1slb]], [[1slc]] – GAL-1 + BGAL – bovine<br />
**[[1gan]] – tGAL-1 + BGAL – toad<br />
**[[1gan]] – tGAL-1 + BGAL – toad<br />
**[[1a78]] – tGAL-1 + thio-digalactose<br />
**[[1a78]] – tGAL-1 + thio-digalactose<br />
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**[[4no4]] - rGAL-1 (mutant) + lactose<br />
**[[4no4]] - rGAL-1 (mutant) + lactose<br />
**[[4lbq]] – mGAL-1 – mouse<br />
**[[4lbq]] – mGAL-1 – mouse<br />
 +
**[[6e20]] – GAL-1 – zebrafish<br />
*Galectin-2
*Galectin-2
 +
**[[5dg1]], [[5dg2]], [[5ews]] - hGAL-2 N-terminal <br />
**[[1ul9]] – CchGAL-2 – ''Coprinopsis cinerea''<br />
**[[1ul9]] – CchGAL-2 – ''Coprinopsis cinerea''<br />
**[[2ymz]] – GAL-2 – chicken<br />
**[[2ymz]] – GAL-2 – chicken<br />
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**[[1uld]], [[2wkk]] – CcGAL-2 + BGAL + fucose<br />
**[[1uld]], [[2wkk]] – CcGAL-2 + BGAL + fucose<br />
**[[1ule]], [[1ulf]] – CcGAL-2 + polysaccharide<br />
**[[1ule]], [[1ulf]] – CcGAL-2 + polysaccharide<br />
-
**[[5dg1]], [[5dg2]], [[5ews]] - hGAL-2 N-terminal <br />
 
*Galectin-3
*Galectin-3
-
**[[3zsk]], [[3zsl]], [[3zsm]], [[5nlc]] – hGAL-3 CRD<br />
+
**[[3zsk]], [[3zsl]], [[3zsm]], [[6exy]], [[5nfc]] – hGAL-3 CRD<br />
**[[6f2q]] - hGAL-3 CRD – neutron<br />
**[[6f2q]] - hGAL-3 CRD – neutron<br />
 +
**[[6fof]] - hGAL-3 CRD (mutant)<br />
**[[1a3k]], [[1kjl]], [[2nmn]] – hGAL-3 CRD + BGAL<br />
**[[1a3k]], [[1kjl]], [[2nmn]] – hGAL-3 CRD + BGAL<br />
**[[2nmo]] - hGAL-3 CRD + glucose + BGAL<br />
**[[2nmo]] - hGAL-3 CRD + glucose + BGAL<br />
-
**[[2nn8]], [[3aye]], [[3zsj]], [[4r9a]], [[4r9b]], [[4r9c]], [[4r9d]], [[4rl7]] - hGAL-3 CRD + lactose<br />
+
**[[2nn8]], [[3aye]], [[3zsj]], [[4r9a]], [[4r9b]], [[4r9c]], [[4r9d]], [[4rl7]], [[6eym]] - hGAL-3 CRD + lactose<br />
-
**[[1kjr ]], [[4xbn]], [[5nf7]], [[5nf9]], [[5nla]], [[5nlb]] – hGAL-3 CRD + lactosamine derivative<br />
+
**[[1kjr ]], [[4xbn]], [[5nf7]], [[5nf9]], [[5nla]], [[5nlb]], [[5nfb]], [[5nfa]] - hGAL-3 CRD + lactosamine derivative<br />
**[[2xg3]], [[3t1l]], [[3t1m]], [[5e88]], [[5e89]], [[5e8a]], [[5exo]], [[5h9p]], [[5h9r]], [[5iuq]] - hGAL-3 CRD + inhibitor<br />
**[[2xg3]], [[3t1l]], [[3t1m]], [[5e88]], [[5e89]], [[5e8a]], [[5exo]], [[5h9p]], [[5h9r]], [[5iuq]] - hGAL-3 CRD + inhibitor<br />
-
**[[3aya]] - hGAL-3 CRD + antigen<br />
+
**[[3aya]], [[6e0v]] - hGAL-3 CRD + antigen<br />
-
**[[3ayc]], [[3ayd]], [[4jc1]], [[4jck]] - hGAL-3 CRD + polysaccharide<br />
+
**[[3ayc]], [[3ayd]], [[4jc1]], [[4jck]], [[6f6y]] - hGAL-3 CRD + polysaccharide<br />
**[[4lbj]], [[4lbk]], [[4lbl]], [[4lbm]], [[4lbn]], [[4lbo]] - hGAL-3 CRD (mutant) + glycosphingolipid<br />
**[[4lbj]], [[4lbk]], [[4lbl]], [[4lbm]], [[4lbn]], [[4lbo]] - hGAL-3 CRD (mutant) + glycosphingolipid<br />
-
**[[4bli]], [[4blj]], [[4bm8]], [[5oax]], [[5ody]] - hGAL-3 CRD + thiogalactoside derivative<br />
+
**[[4bli]], [[4blj]], [[4bm8]], [[5oax]], [[5ody]], [[6i74]], [[6i75]], [[6i76]], [[6i77]], [[6i78]] - hGAL-3 CRD + thiogalactoside derivative<br />
 +
**[[6eol]], [[6eog]] - hGAL-3 CRD + galactose derivative<br />
 +
**[[6qge]], [[6qgf]] - hGAL-3 CRD + ligand<br />
 +
**[[6fk2]] - hGAL-3 CRD + lactitol<br />
 +
**[[6b8k]] - hGAL-3 CRD + lactulose<br />
*Galectin-4
*Galectin-4
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*Galectin-9
*Galectin-9
-
**[[2d6k]], [[2d6l]] – mGAL-9 CRD<br />
 
-
**[[2d6m]] – mGAL-9 CRD + lactose<br />
 
-
**[[2d6n]], [[2d6o]]– mGAL-9 CRD + acetyllactosamine<br />
 
-
**[[2d6p]] – mGAL-9 CRD + antigen<br />
 
**[[3lsd]] – hGAL-9 N terminal<br />
**[[3lsd]] – hGAL-9 N terminal<br />
**[[3wv6]] – hGAL-9 (mutant)<br />
**[[3wv6]] – hGAL-9 (mutant)<br />
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**[[2zhk]], [[2zhl]], [[2zhm]], [[2zhn]], [[3nv2]] - hGAL-9 CRD + acetyllactosamine<br />
**[[2zhk]], [[2zhl]], [[2zhm]], [[2zhn]], [[3nv2]] - hGAL-9 CRD + acetyllactosamine<br />
**[[3nv3]] - hGAL-9 CRD + polysaccharide<br />
**[[3nv3]] - hGAL-9 CRD + polysaccharide<br />
-
**[[2eal]] - mGAL-9 CRD + pentasaccharide
+
**[[2eal]] - mGAL-9 CRD + pentasaccharide<br />
 +
**[[2d6k]], [[2d6l]] – mGAL-9 CRD<br />
 +
**[[2d6m]] – mGAL-9 CRD + lactose<br />
 +
**[[2d6n]], [[2d6o]]– mGAL-9 CRD + acetyllactosamine<br />
 +
**[[2d6p]] – mGAL-9 CRD + antigen<br />
*Galectin-10
*Galectin-10
-
**[[5xrg]], [[5xrh]] – hGAL-10 <br />
+
**[[5xrg]], [[5xrh]], [[6gks]], [[6gkq]] – hGAL-10 <br />
-
**[[5yt4]], [[5xri]], [[5xrj]], [[5xrk]], [[5xrl]], [[5xrm]], [[5xrn]], [[5xro]], [[5xrp]] – hGAL-10 (mutant)<br />
+
**[[5yt4]], [[5xri]], [[5xrj]], [[5xrk]], [[5xrl]], [[5xrm]], [[5xrn]], [[5xro]], [[5xrp]], [[6gkt]], [[6a1y]], [[6a1x]], [[6a1v]], [[6a1u]], [[6a1s]] – hGAL-10 (mutant)<br />
**[[1bkz]] – hGAL-10 + mannose<br />
**[[1bkz]] – hGAL-10 + mannose<br />
-
**[[1hdk]] – hGAL-10 + PCMBS
+
**[[1hdk]] – hGAL-10 + PCMBS<br />
 +
**[[6a1t]] – hGAL-10 (mutant) + lactose<br />
 +
**[[5xrh]] – hGAL-10 + ribose<br />
 +
**[[6glw]], [[6glx]], [[6gku]] – hGAL-10 + antibody<br />
*Galectin-13 or galactoside-binding soluble lectin 13
*Galectin-13 or galactoside-binding soluble lectin 13
**[[5xg7]] – hGAL-13 <br />
**[[5xg7]] – hGAL-13 <br />
-
**[[5y03]], [[5xg9]] – hGAL-13 (mutant)<br />
+
**[[5y03]], [[5xg9]], [[6a65]], [[6a66]], [[5xg8]] – hGAL-13 (mutant)<br />
 +
**[[6a62]], [[6a63]], [[6a64]] – hGAL-13 (mutant) + lactose<br />
*Galectin
*Galectin

Revision as of 08:26, 9 July 2019

Structure of human galectin-1 complex with lactose, mercaptoethanol and sulfate (PDB entry 1w6o)

Drag the structure with the mouse to rotate

3D structures of galectin

Updated on 09-July-2019

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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