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2v5o

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[[Image:2v5o.jpg|left|200px]]
[[Image:2v5o.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2v5o |SIZE=350|CAPTION= <scene name='initialview01'>2v5o</scene>, resolution 2.91&Aring;
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The line below this paragraph, containing "STRUCTURE_2v5o", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Cl+Binding+Site+For+Chain+A'>AC4</scene> and <scene name='pdbsite=AC5:Cl+Binding+Site+For+Chain+A'>AC5</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2v5o| PDB=2v5o | SCENE= }}
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|RELATEDENTRY=[[1e6f|1E6F]], [[1gp0|1GP0]], [[1gp3|1GP3]], [[1gqb|1GQB]], [[1jpl|1JPL]], [[1jwg|1JWG]], [[1lf8|1LF8]], [[2cnj|2CNJ]], [[2v5n|2V5N]], [[2v5p|2V5P]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5o OCA], [http://www.ebi.ac.uk/pdbsum/2v5o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v5o RCSB]</span>
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}}
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'''STRUCTURE OF HUMAN IGF2R DOMAINS 11-14'''
'''STRUCTURE OF HUMAN IGF2R DOMAINS 11-14'''
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[[Category: Wallace, J C.]]
[[Category: Wallace, J C.]]
[[Category: Zaccheo, O J.]]
[[Category: Zaccheo, O J.]]
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[[Category: beta barrel]]
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[[Category: Beta barrel]]
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[[Category: cation independent mannose 6-phosphate]]
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[[Category: Cation independent mannose 6-phosphate]]
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[[Category: fibronectin type ii]]
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[[Category: Fibronectin type ii]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: insulin-like growth factor]]
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[[Category: Insulin-like growth factor]]
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[[Category: lysosome]]
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[[Category: Lysosome]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: transport]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:30:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:08:30 2008''
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Revision as of 06:30, 24 April 2008

Image:2v5o.jpg

Template:STRUCTURE 2v5o

STRUCTURE OF HUMAN IGF2R DOMAINS 11-14


Overview

Embryonic development and normal growth require exquisite control of insulin-like growth factors (IGFs). In mammals the extracellular region of the cation-independent mannose-6-phosphate receptor has gained an IGF-II-binding function and is termed type II IGF receptor (IGF2R). IGF2R sequesters IGF-II; imbalances occur in cancers and IGF2R is implicated in tumour suppression. We report crystal structures of IGF2R domains 11-12, 11-12-13-14 and domains 11-12-13/IGF-II complex. A distinctive juxtaposition of these domains provides the IGF-II-binding unit, with domain 11 directly interacting with IGF-II and domain 13 modulating binding site flexibility. Our complex shows that Phe19 and Leu53 of IGF-II lock into a hydrophobic pocket unique to domain 11 of mammalian IGF2Rs. Mutagenesis analyses confirm this IGF-II 'binding-hotspot', revealing that IGF-binding proteins and IGF2R have converged on the same high-affinity site.

About this Structure

2V5O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and functional analysis of the IGF-II/IGF2R interaction., Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY, EMBO J. 2008 Jan 9;27(1):265-76. Epub 2007 Nov 29. PMID:18046459 Page seeded by OCA on Thu Apr 24 09:30:03 2008

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