5qrn
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z54226006== | |
| - | + | <StructureSection load='5qrn' size='340' side='right'caption='[[5qrn]], [[Resolution|resolution]] 1.62Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5qrn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QRN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NX7:(2,6-difluorophenyl)(pyrrolidin-1-yl)methanone'>NX7</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qrn OCA], [http://pdbe.org/5qrn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qrn RCSB], [http://www.ebi.ac.uk/pdbsum/5qrn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qrn ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Burgess-Brown, N A]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Edwards, A]] | ||
[[Category: Fernandez-Cid, A]] | [[Category: Fernandez-Cid, A]] | ||
| - | [[Category: | + | [[Category: Gavard, A E]] |
[[Category: Gileadi, O]] | [[Category: Gileadi, O]] | ||
| - | [[Category: Newman, J | + | [[Category: Newman, J A]] |
| - | [[Category: | + | [[Category: Sherestha, L]] |
| - | [[Category: | + | [[Category: Pandda]] |
| - | [[Category: | + | [[Category: Sgc - diamond i04-1 fragment screening]] |
| - | [[Category: | + | [[Category: Transcription]] |
| - | [[Category: | + | [[Category: Xchemexplorer]] |
Revision as of 05:36, 10 July 2019
PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z54226006
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