6e1f

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'''Unreleased structure'''
 
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The entry 6e1f is ON HOLD until Paper Publication
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==Crystal structure of the SWIRM domain of human histone lysine-specific demethylase LSD1==
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<StructureSection load='6e1f' size='340' side='right'caption='[[6e1f]], [[Resolution|resolution]] 1.16&Aring;' scene=''>
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Authors: Luka, Z., Pakhomova, S., Reiter, N.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6e1f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E1F FirstGlance]. <br>
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Description: Crystal structure of the SWIRM domain of human histone lysine-specific demethylase LSD1
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e1f OCA], [http://pdbe.org/6e1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e1f RCSB], [http://www.ebi.ac.uk/pdbsum/6e1f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e1f ProSAT]</span></td></tr>
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[[Category: Reiter, N.J]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN]] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Luka, Z]]
[[Category: Pakhomova, S]]
[[Category: Pakhomova, S]]
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[[Category: Luka, Z]]
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[[Category: Reiter, N J]]
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[[Category: Histone lysine specific demethylase]]
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[[Category: Oxidoreductase]]
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[[Category: Swirm domain]]

Revision as of 05:41, 10 July 2019

Crystal structure of the SWIRM domain of human histone lysine-specific demethylase LSD1

PDB ID 6e1f

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