6jce

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'''Unreleased structure'''
 
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The entry 6jce is ON HOLD until Paper Publication
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==NMR solution and X-ray crystal structures of a DNA containing both right-and left-handed parallel-stranded G-quadruplexes==
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<StructureSection load='6jce' size='340' side='right'caption='[[6jce]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6jce]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JCE FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jce OCA], [http://pdbe.org/6jce PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jce RCSB], [http://www.ebi.ac.uk/pdbsum/6jce PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jce ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Analogous to the B- and Z-DNA structures in double-helix DNA, there exist both right- and left-handed quadruple-helix (G-quadruplex) DNA. Numerous conformations of right-handed and a few left-handed G-quadruplexes were previously observed, yet they were always identified separately. Here, we present the NMR solution and X-ray crystal structures of a right- and left-handed hybrid G-quadruplex. The structure reveals a stacking interaction between two G-quadruplex blocks with different helical orientations and displays features of both right- and left-handed G-quadruplexes. An analysis of loop mutations suggests that single-nucleotide loops are preferred or even required for the left-handed G-quadruplex formation. The discovery of a right- and left-handed hybrid G-quadruplex further expands the polymorphism of G-quadruplexes and is potentially useful in designing a left-to-right junction in G-quadruplex engineering.
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Authors: Winnerdy, F.R., Bakalar, B., Maity, A., Vandana, J.J., Mechulam, Y., Schmitt, E., Phan, A.T.
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NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes.,Winnerdy FR, Bakalar B, Maity A, Vandana JJ, Mechulam Y, Schmitt E, Phan AT Nucleic Acids Res. 2019 Jun 19. pii: 5520578. doi: 10.1093/nar/gkz349. PMID:31216034<ref>PMID:31216034</ref>
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Description: NMR solution and X-ray crystal structures of a DNA containing both right-and left-handed parallel-stranded G-quadruplexes
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Schmitt, E]]
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<div class="pdbe-citations 6jce" style="background-color:#fffaf0;"></div>
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[[Category: Vandana, J.J]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Bakalar, B]]
[[Category: Maity, A]]
[[Category: Maity, A]]
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[[Category: Phan, A.T]]
 
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[[Category: Winnerdy, F.R]]
 
[[Category: Mechulam, Y]]
[[Category: Mechulam, Y]]
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[[Category: Bakalar, B]]
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[[Category: Phan, A T]]
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[[Category: Schmitt, E]]
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[[Category: Vandana, J J]]
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[[Category: Winnerdy, F R]]
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[[Category: Dna]]
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[[Category: G-quadruplex]]
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[[Category: Hybrid]]
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[[Category: Left-handed]]
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[[Category: Z-g4]]

Revision as of 05:44, 10 July 2019

NMR solution and X-ray crystal structures of a DNA containing both right-and left-handed parallel-stranded G-quadruplexes

PDB ID 6jce

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