6n86
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Resistance to inhibitors of cholinesterase 8A (Ric8A) protein== | |
| - | + | <StructureSection load='6n86' size='340' side='right'caption='[[6n86]], [[Resolution|resolution]] 3.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6n86]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N86 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N86 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n86 OCA], [http://pdbe.org/6n86 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n86 RCSB], [http://www.ebi.ac.uk/pdbsum/6n86 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n86 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Artemyev, N | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/RIC8A_BOVIN RIC8A_BOVIN]] Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Artemyev, N O]] | ||
[[Category: Gakhar, L]] | [[Category: Gakhar, L]] | ||
[[Category: Srivastava, D]] | [[Category: Srivastava, D]] | ||
| + | [[Category: Armadillo repeat]] | ||
| + | [[Category: Chaperone]] | ||
| + | [[Category: G alpha]] | ||
| + | [[Category: Ric8a]] | ||
Revision as of 05:46, 10 July 2019
Resistance to inhibitors of cholinesterase 8A (Ric8A) protein
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