6n85

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'''Unreleased structure'''
 
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The entry 6n85 is ON HOLD until Paper Publication
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==Resistance to inhibitors of cholinesterase 8A (Ric8A) protein in complex with MBP-tagged transducin-alpha residues 327-350==
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<StructureSection load='6n85' size='340' side='right'caption='[[6n85]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6n85]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N85 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N85 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n85 OCA], [http://pdbe.org/6n85 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n85 RCSB], [http://www.ebi.ac.uk/pdbsum/6n85 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n85 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RIC8A_BOVIN RIC8A_BOVIN]] Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity). [[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Artemyev, N O]]
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[[Category: Gakhar, L]]
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[[Category: Srivastava, D]]
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[[Category: Armadillo repeat]]
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[[Category: Chaperone]]
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[[Category: G alpha]]
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[[Category: Mbp]]
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[[Category: Ric8a]]

Revision as of 05:47, 10 July 2019

Resistance to inhibitors of cholinesterase 8A (Ric8A) protein in complex with MBP-tagged transducin-alpha residues 327-350

PDB ID 6n85

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