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6qtw

From Proteopedia

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'''Unreleased structure'''
 
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The entry 6qtw is ON HOLD until Paper Publication
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==Crystal structure of an Arabidopsis WD40 domain in complex with a blue light photoreceptor==
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<StructureSection load='6qtw' size='340' side='right'caption='[[6qtw]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
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Authors: Hothorn, M., Lau, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6qtw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QTW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QTW FirstGlance]. <br>
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Description: Crystal structure of an Arabidopsis WD40 domain in complex with a blue light photoreceptor
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RING-type_E3_ubiquitin_transferase RING-type E3 ubiquitin transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.27 2.3.2.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qtw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qtw OCA], [http://pdbe.org/6qtw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qtw RCSB], [http://www.ebi.ac.uk/pdbsum/6qtw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qtw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/COP1_ARATH COP1_ARATH]] E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways.<ref>PMID:11967090</ref> <ref>PMID:12023303</ref> [[http://www.uniprot.org/uniprot/CRY1_ARATH CRY1_ARATH]] Mediates blue light-induced gene expression through the inhibition of COP1-mediated degradation of the transcription factor BIT1. Involved in blue light-dependent stomatal opening, CHS gene expression, inhibition of stem growth and increase of root growth.<ref>PMID:7756321</ref> <ref>PMID:9565033</ref> <ref>PMID:16093319</ref> <ref>PMID:16703358</ref> <ref>PMID:18397371</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: RING-type E3 ubiquitin transferase]]
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[[Category: Hothorn, M]]
[[Category: Lau, K]]
[[Category: Lau, K]]
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[[Category: Hothorn, M]]
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[[Category: Complex]]
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[[Category: Plant protein]]

Revision as of 05:56, 10 July 2019

Crystal structure of an Arabidopsis WD40 domain in complex with a blue light photoreceptor

PDB ID 6qtw

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