6rgi
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Partially unfolded cytochrome c in complex with sulfonatocalix[6]arene== | |
| + | <StructureSection load='6rgi' size='340' side='right'caption='[[6rgi]], [[Resolution|resolution]] 2.64Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6rgi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RGI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RGI FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FWQ:p-sulfonatocalix[6]arene'>FWQ</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rgi OCA], [http://pdbe.org/6rgi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rgi RCSB], [http://www.ebi.ac.uk/pdbsum/6rgi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rgi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CYC1_YEAST CYC1_YEAST]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Supramolecular receptors such as water-soluble calixarenes are in development as 'molecular glues' for protein assembly. Here, we obtained cocrystals of sulfonato-calix[6]arene (sclx6 ) and yeast cytochrome c (cytc) in the presence of imidazole. A crystal structure at 2.65 A resolution reveals major structural rearrangement and disorder in imidazole-bound cytc. The largest protein-calixarene interface involves 440 A(2) of the protein surface with key contacts at Arg13, Lys73, and Lys79. These lysines participate in alkaline transitions of cytc and are part of Omega-loop D, which is substantially restructured in the complex with sclx6 . The structural modification also includes Omega-loop C, which is disordered (residues 41-55 inclusive). These results suggest the possibility of using supramolecular scaffolds to trap partially disordered proteins. | ||
| - | + | Calixarene capture of partially unfolded cytochrome c.,Engilberge S, Rennie ML, Crowley PB FEBS Lett. 2019 Jun 29. doi: 10.1002/1873-3468.13512. PMID:31254353<ref>PMID:31254353</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Crowley, P | + | <div class="pdbe-citations 6rgi" style="background-color:#fffaf0;"></div> |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Crowley, P B]] | ||
[[Category: Engilberge, S]] | [[Category: Engilberge, S]] | ||
| + | [[Category: Rennie, M L]] | ||
| + | [[Category: Calixarene]] | ||
| + | [[Category: Electron transport]] | ||
| + | [[Category: Molecular glue]] | ||
| + | [[Category: Protein assembly]] | ||
| + | [[Category: Supramolecular chemistry]] | ||
Revision as of 05:58, 10 July 2019
Partially unfolded cytochrome c in complex with sulfonatocalix[6]arene
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