3bs6

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[[Image:3bs6.jpg|left|200px]]
[[Image:3bs6.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3bs6 |SIZE=350|CAPTION= <scene name='initialview01'>3bs6</scene>, resolution 1.800&Aring;
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The line below this paragraph, containing "STRUCTURE_3bs6", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:Ca+Binding+Site+For+Residue+A+2'>AC2</scene>, <scene name='pdbsite=AC3:Ca+Binding+Site+For+Residue+A+3'>AC3</scene>, <scene name='pdbsite=AC4:Ca+Binding+Site+For+Residue+A+4'>AC4</scene>, <scene name='pdbsite=AC5:Ca+Binding+Site+For+Residue+A+5'>AC5</scene>, <scene name='pdbsite=AC6:2pe+Binding+Site+For+Residue+B+1'>AC6</scene>, <scene name='pdbsite=AC7:Pg4+Binding+Site+For+Residue+A+336'>AC7</scene>, <scene name='pdbsite=AC8:Pge+Binding+Site+For+Residue+A+337'>AC8</scene>, <scene name='pdbsite=AC9:Pge+Binding+Site+For+Residue+B+336'>AC9</scene>, <scene name='pdbsite=BC1:Pge+Binding+Site+For+Residue+A+338'>BC1</scene>, <scene name='pdbsite=BC2:Edo+Binding+Site+For+Residue+B+337'>BC2</scene>, <scene name='pdbsite=BC3:Edo+Binding+Site+For+Residue+A+339'>BC3</scene>, <scene name='pdbsite=BC4:Edo+Binding+Site+For+Residue+B+3'>BC4</scene>, <scene name='pdbsite=BC5:Edo+Binding+Site+For+Residue+A+340'>BC5</scene>, <scene name='pdbsite=BC6:Edo+Binding+Site+For+Residue+B+6'>BC6</scene> and <scene name='pdbsite=BC7:Edo+Binding+Site+For+Residue+A+7'>BC7</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= oxaA, yidC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_3bs6| PDB=3bs6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bs6 OCA], [http://www.ebi.ac.uk/pdbsum/3bs6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bs6 RCSB]</span>
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}}
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'''1.8 Angstrom crystal structure of the periplasmic domain of the membrane insertase YidC'''
'''1.8 Angstrom crystal structure of the periplasmic domain of the membrane insertase YidC'''
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[[Category: Ravaud, S.]]
[[Category: Ravaud, S.]]
[[Category: Sinning, I.]]
[[Category: Sinning, I.]]
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[[Category: beta supersandwich fold]]
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[[Category: Beta supersandwich fold]]
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[[Category: chaperone]]
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[[Category: Chaperone]]
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[[Category: helical linker domain]]
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[[Category: Helical linker domain]]
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[[Category: membrane insertion]]
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[[Category: Membrane insertion]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: periplasmic domain]]
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[[Category: Periplasmic domain]]
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[[Category: protein transport]]
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[[Category: Protein transport]]
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[[Category: sec translocon]]
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[[Category: Sec translocon]]
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[[Category: yidc/oxa1/alb3 family]]
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[[Category: Yidc/oxa1/alb3 family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:33:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:28:36 2008''
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Revision as of 06:33, 24 April 2008

Image:3bs6.jpg

Template:STRUCTURE 3bs6

1.8 Angstrom crystal structure of the periplasmic domain of the membrane insertase YidC


Overview

In bacteria the biogenesis of inner membrane proteins requires targeting and insertion factors such as the signal recognition particle and the Sec-translocon. YidC is an essential membrane protein involved in the insertion of inner membrane proteins together with the Sec-translocon, but also as a separate entity. YidC of Escherichia coli is a member of the conserved YidC (in bacteria)/Oxa1 (in mitochondria)/Alb3 (in chloroplasts) protein family and contains six transmembrane segments and a large periplasmic domain (P1). We determined the crystal structure of the periplasmic domain of YidC from E.coli (P1D) at 1.8A resolution. The structure of P1D shows the conserved ss-supersandwich-fold of carbohydrate binding proteins and an a-helical linker region at the C-terminus that packs against the ss-supersandwich by a highly conserved interface. P1D exhibits an elongated cleft of similar architecture as found in the structural homologs. However the electrostatic properties and molecular details of the cleft make it unlikely to interact with carbohydrate substrates. The cleft in P1D is occupied by a polyethylene glycol molecule suggesting an elongated peptide or acyl chain as a natural ligand. The region of P1D previously reported to interact with SecF maps to a surface area in the vicinity of the cleft. The conserved C-terminal region of the P1 domain was reported to be essential for the membrane insertase function of YidC. The analysis of this region suggests a role in membrane interaction and/or in the regulation of YidC interaction with binding partners.

About this Structure

3BS6 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The crystal structure of the periplasmic domain of the Escherichia coli membrane protein insertase YidC contains a conserved substrate binding cleft., Ravaud S, Stjepanovic G, Wild K, Sinning I, J Biol Chem. 2008 Jan 30;. PMID:18234665 Page seeded by OCA on Thu Apr 24 09:33:37 2008

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