3bt2
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:3bt2.jpg|left|200px]] | [[Image:3bt2.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_3bt2", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_3bt2| PDB=3bt2 | SCENE= }} | |
| - | | | + | |
| - | + | ||
| - | }} | + | |
'''Structure of urokinase receptor, urokinase and vitronectin complex''' | '''Structure of urokinase receptor, urokinase and vitronectin complex''' | ||
| + | |||
| + | ==Overview== | ||
| + | The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands. | ||
==Disease== | ==Disease== | ||
| Line 20: | Line 20: | ||
==About this Structure== | ==About this Structure== | ||
3BT2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BT2 OCA]. | 3BT2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BT2 OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes., Huai Q, Zhou A, Lin L, Mazar AP, Parry GC, Callahan J, Shaw DE, Furie B, Furie BC, Huang M, Nat Struct Mol Biol. 2008 Apr;15(4):422-3. Epub 2008 Mar 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18376415 18376415] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Huang, M.]] | [[Category: Huang, M.]] | ||
| - | [[Category: | + | [[Category: Alternative splicing]] |
| - | [[Category: | + | [[Category: Blood coagulation]] |
| - | [[Category: | + | [[Category: Cell adhesion]] |
| - | [[Category: | + | [[Category: Egf-like domain]] |
| - | [[Category: | + | [[Category: Fibrinolysis]] |
| - | [[Category: | + | [[Category: Glycoprotein]] |
| - | [[Category: | + | [[Category: Gpi-anchor]] |
| - | [[Category: | + | [[Category: Heparin-binding]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | [[Category: | + | [[Category: Immune system]] |
| - | [[Category: | + | [[Category: Immunoglobulin domain]] |
| - | [[Category: | + | [[Category: Kringle]] |
| - | [[Category: | + | [[Category: Lipoprotein]] |
| - | [[Category: | + | [[Category: Membrane]] |
| - | [[Category: | + | [[Category: Pharmaceutical]] |
| - | [[Category: | + | [[Category: Phosphoprotein]] |
| - | [[Category: | + | [[Category: Plasminogen activation]] |
| - | [[Category: | + | [[Category: Polymorphism]] |
| - | [[Category: | + | [[Category: Protease]] |
| - | [[Category: | + | [[Category: Protein-protein interaction]] |
| - | [[Category: | + | [[Category: Receptor]] |
| - | [[Category: | + | [[Category: Secreted]] |
| - | [[Category: | + | [[Category: Serine protease]] |
| - | [[Category: | + | [[Category: Sulfation]] |
| - | [[Category: | + | [[Category: Zymogen]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:33:48 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:33, 24 April 2008
Structure of urokinase receptor, urokinase and vitronectin complex
Contents |
Overview
The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.
Disease
Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]
About this Structure
3BT2 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes., Huai Q, Zhou A, Lin L, Mazar AP, Parry GC, Callahan J, Shaw DE, Furie B, Furie BC, Huang M, Nat Struct Mol Biol. 2008 Apr;15(4):422-3. Epub 2008 Mar 23. PMID:18376415 Page seeded by OCA on Thu Apr 24 09:33:48 2008
Categories: Homo sapiens | Mus musculus | Protein complex | Huang, M. | Alternative splicing | Blood coagulation | Cell adhesion | Egf-like domain | Fibrinolysis | Glycoprotein | Gpi-anchor | Heparin-binding | Hydrolase | Immune system | Immunoglobulin domain | Kringle | Lipoprotein | Membrane | Pharmaceutical | Phosphoprotein | Plasminogen activation | Polymorphism | Protease | Protein-protein interaction | Receptor | Secreted | Serine protease | Sulfation | Zymogen
