Glucocorticoid receptor
From Proteopedia
(Difference between revisions)
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GCR contains 5 domains: N terminal regulatory domain; DNA-binding domain (DBD) residues 417-506; hinge region; ligand-binding domain (LBD) residues 521-777 and C terminal domain. | GCR contains 5 domains: N terminal regulatory domain; DNA-binding domain (DBD) residues 417-506; hinge region; ligand-binding domain (LBD) residues 521-777 and C terminal domain. | ||
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| + | ==3D structures of glucocorticoid receptor== | ||
| + | [[Glucocorticoid receptor 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of glucocorticoid receptor== | ==3D structures of glucocorticoid receptor== | ||
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*Glucocorticoid receptor DBD domain residues 391-480 | *Glucocorticoid receptor DBD domain residues 391-480 | ||
| + | **[[6cfn]] - hGCR DBD <br /> | ||
| + | **[[4hn5]], [[4hn6]], [[5emp]], [[5emq]], [[5emc]], [[5e69]], [[5e6a]], [[5e6b]], [[5e6c]], [[5e6d]], [[5cbx]], [[5cby]], [[5cbz]], [[6bqu]] - hGCR DBD + DNA<br /> | ||
| + | **[[5cc1]] - hGCR DBD (mutant) + DNA <br /> | ||
**[[1gdc]], [[2gda]], [[1rgd]] – rGCR DBD – NMR – rat<br /> | **[[1gdc]], [[2gda]], [[1rgd]] – rGCR DBD – NMR – rat<br /> | ||
**[[3g9p]], [[3fyl]], [[3g6p]], [[3g6q]], [[3g6r]], [[3g6t]], [[3g6u]], [[3g8u]], [[3g8x]], [[3g97]], [[3g99]], [[3g9i]], [[3g9m]], [[3g9j]], [[3g9o]], [[1glu]], [[1lat]], [[1r4o]], [[1r4r]] - rGCR DBD + DNA<br /> | **[[3g9p]], [[3fyl]], [[3g6p]], [[3g6q]], [[3g6r]], [[3g6t]], [[3g6u]], [[3g8u]], [[3g8x]], [[3g97]], [[3g99]], [[3g9i]], [[3g9m]], [[3g9j]], [[3g9o]], [[1glu]], [[1lat]], [[1r4o]], [[1r4r]] - rGCR DBD + DNA<br /> | ||
| - | **[[4hn5]], [[4hn6]], [[5emp]], [[5emq]], [[5emc]], [[5e69]], [[5e6a]], [[5e6b]], [[5e6c]], [[5e6d]], [[5cbx]], [[5cby]], [[5cbz]] - hGCR DBD + DNA – human<br /> | ||
| - | **[[5cc1]] - hGCR DBD (mutant) + DNA <br /> | ||
*Glucocorticoid receptor LBD domain residues 500-777 complex with NCOA peptide | *Glucocorticoid receptor LBD domain residues 500-777 complex with NCOA peptide | ||
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**[[5uc3]] - hGCR LBD (mutant) + RU-486<br /> | **[[5uc3]] - hGCR LBD (mutant) + RU-486<br /> | ||
**[[3k22]] - hGCR LBD (mutant) + transcriptional intermediary factor 2 peptide + alaninamide<br /> | **[[3k22]] - hGCR LBD (mutant) + transcriptional intermediary factor 2 peptide + alaninamide<br /> | ||
| - | + | **[[6dxk]] – hGCR LBD + antagonist<br /> | |
*Glucocorticoid receptor 2 | *Glucocorticoid receptor 2 | ||
Revision as of 09:24, 10 July 2019
Rat glucocorticoid receptor DNA-binding domain dimer complex with DNA and Zn+2 ions (grey) (PDB entry 3g6r)
Drag the structure with the mouse to rotate 3D structures of glucocorticoid receptor
Updated on 10-July-2019
References
- ↑ Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol Rev. 2006 Dec;58(4):782-97. PMID:17132855 doi:http://dx.doi.org/10.1124/pr.58.4.9
- ↑ Finsterwald C, Alberini CM. Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies. Neurobiol Learn Mem. 2014 Jul;112:17-29. doi: 10.1016/j.nlm.2013.09.017. Epub, 2013 Oct 7. PMID:24113652 doi:http://dx.doi.org/10.1016/j.nlm.2013.09.017
