MEP cytidylyltransferase

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Revision as of 10:23, 10 July 2019

Structure of E. coli MEP cytidylyltransferase complex with CTP, Mg+2 (small light green) and Ca+2 (large green) (PDB code 1i52).

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Updated on 10-July-2019

↑ Friedrich R, Fuentes-Prior P, Ong E, Coombs G, Hunter M, Oehler R, Pierson D, Gonzalez R, Huber R, Bode W, Madison EL. Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem. 2002 Jan 18;277(3):2160-8. Epub 2001 Nov 5. PMID:11696548 doi:10.1074/jbc.M109830200
↑ Tsang A, Seidle H, Jawaid S, Zhou W, Smith C, Couch RD. Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. PLoS One. 2011;6(6):e20884. doi: 10.1371/journal.pone.0020884. Epub 2011 Jun 9. PMID:21694781 doi:http://dx.doi.org/10.1371/journal.pone.0020884
↑ Richard SB, Bowman ME, Kwiatkowski W, Kang I, Chow C, Lillo AM, Cane DE, Noel JP. Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis. Nat Struct Biol. 2001 Jul;8(7):641-8. PMID:11427897 doi:10.1038/89691

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 == Structural highlights ==
-The biological assembly of ''E. coli'' MEPCT is <scene name='59/595219/Cv/7'>homodimer</scene>. The <scene name='59/595219/Cv/5'>active site of MEPCT contains an Mg+2 ion</scene><ref>PMID:11427897</ref>. Water molecules shown as red spheres. <scene name='59/595219/Cv/6'>Whole active site</scene>.
+The biological assembly of ''E. coli'' MEPCT is <scene name='59/595219/Cv/8'>homodimer</scene>. The <scene name='59/595219/Cv/9'>active site of MEPCT contains an Mg+2 ion</scene><ref>PMID:11427897</ref>. Water molecules shown as red spheres. <scene name='59/595219/Cv/10'>Whole active site</scene>.
 </StructureSection>