Glucuronidase

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The <scene name='59/596476/Cv/3'>catalytic pocket</scene> of BGUS contains <scene name='59/596476/Cv/4'>two catalytic Glu residues</scene><ref>PMID:22367201</ref>.
The <scene name='59/596476/Cv/3'>catalytic pocket</scene> of BGUS contains <scene name='59/596476/Cv/4'>two catalytic Glu residues</scene><ref>PMID:22367201</ref>.
 +
== 3D Structures of glucuronisidase ==
 +
[[Glucuronisidase 3D structures]]
</StructureSection>
</StructureSection>
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**[[4c90]], [[4c91]] – AGUS – ''Bacteroides ovatus'' <br />
**[[4c90]], [[4c91]] – AGUS – ''Bacteroides ovatus'' <br />
**[[5c70]] – AoAGUS – ''Aspergillus oryzae'' <br />
**[[5c70]] – AoAGUS – ''Aspergillus oryzae'' <br />
 +
**[[6ncy]] – FsAGUS – ''Fusicatenibacter saccharivorans'' <br />
*α-D-glucuronidase binary complex
*α-D-glucuronidase binary complex
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**[[1h41]] – PcAGUS (mutant) + aldotriuronic acid <br />
**[[1h41]] – PcAGUS (mutant) + aldotriuronic acid <br />
**[[5c71]] – AoAGUS + glycyrrhetinic acid monoglucuronide<br />
**[[5c71]] – AoAGUS + glycyrrhetinic acid monoglucuronide<br />
 +
**[[6ncz]] – FsAGUS + glucuronide derivative <br />
*α-D-glucuronidase ternary complex
*α-D-glucuronidase ternary complex
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**[[3vny]] – AcBGUS – ''Acidobacterium capsulatum'' <br />
**[[3vny]] – AcBGUS – ''Acidobacterium capsulatum'' <br />
**[[4jkk]], [[4jkl]] – BGUS – ''Streptococcus agalactiae'' <br />
**[[4jkk]], [[4jkl]] – BGUS – ''Streptococcus agalactiae'' <br />
 +
**[[6mvg]], [[6ec6]], [[5z18]] – RgBGUS – ''Ruminococcus gnavus'' <br />
 +
**[[6eca]] – BGUS – ''Lactobacillus rhamnosus''<br />
 +
**[[6d7j]] – BGUS – ''Parabacterioides merdae'' <br />
-
*β-glucuronidase binary complex
+
*β-glucuronidase complex
**[[3vnz]] – AcBGUS + glucuronic acid <br />
**[[3vnz]] – AcBGUS + glucuronic acid <br />
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**[[3k4d]] – EcBGUS + glucaro-D-lactam <br />
**[[3k4d]] – EcBGUS + glucaro-D-lactam <br />
**[[3lpf]], [[3lpg]], [[4jhz]], [[5czk]] – EcBGUS + inhibitor <br />
**[[3lpf]], [[3lpg]], [[4jhz]], [[5czk]] – EcBGUS + inhibitor <br />
-
**[[4jkm]] – BGUS + MBP – ''Clostridium perfringens'' <br />
+
**[[4jkm]] – CpBGUS + MBP – ''Clostridium perfringens'' <br />
 +
**[[6cxs]] – CpBGUS + MBP + inhibitor<br />
 +
**[[6d4o]] – BGUS + glucuronic acid derivative – ''Eubacterium eligens''<br />
 +
**[[5z19]] – RgBGUS (mutant) + uronic isofagomine <br />
}}
}}

Revision as of 07:54, 11 July 2019

β-glucuronidase complex with glucouronic acid, glycerol and PO4 ion (PDB code 3vnz).

Drag the structure with the mouse to rotate

3D Structures of glucuronisidase

Updated on 11-July-2019


References

  1. ↑ Jain S, Drendel WB, Chen ZW, Mathews FS, Sly WS, Grubb JH. Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs. Nat Struct Biol. 1996 Apr;3(4):375-81. PMID:8599764
  2. ↑ Nagy T, Emami K, Fontes CM, Ferreira LM, Humphry DR, Gilbert HJ. The membrane-bound alpha-glucuronidase from Pseudomonas cellulosa hydrolyzes 4-O-methyl-D-glucuronoxylooligosaccharides but not 4-O-methyl-D-glucuronoxylan. J Bacteriol. 2002 Sep;184(17):4925-9. PMID:12169619
  3. ↑ doi: https://dx.doi.org/10.2210/pdb3lpf/pdb
  4. ↑ Sparreboom A, de Jonge MJ, de Bruijn P, Brouwer E, Nooter K, Loos WJ, van Alphen RJ, Mathijssen RH, Stoter G, Verweij J. Irinotecan (CPT-11) metabolism and disposition in cancer patients. Clin Cancer Res. 1998 Nov;4(11):2747-54. PMID:9829738
  5. ↑ doi: https://dx.doi.org/10.2210/pdb3hn3/pdb
  6. ↑ Michikawa M, Ichinose H, Momma M, Biely P, Jongkees S, Yoshida M, Kotake T, Tsumuraya Y, Withers SG, Fujimoto Z, Kaneko S. Structural and biochemical characterization of glycoside hydrolase family 79 beta-glucuronidase from Acidobacterium capsulatum. J Biol Chem. 2012 Apr 20;287(17):14069-77. Epub 2012 Feb 24. PMID:22367201 doi:http://dx.doi.org/10.1074/jbc.M112.346288

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