Glutamate dehydrogenase
From Proteopedia
(Difference between revisions)
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The biological assembly of GLDH from ''Clostridium symbiosum'' is <scene name='49/490918/Cv/6'>homohexamer</scene>. The <scene name='49/490918/Cv/7'>glutamate binding pocket of GLDH</scene> is in a cleft between the two domains of the enzyme with <scene name='49/490918/Cv/8'>residue D165 serving as a general base and a protein-bound water molecule as the attacking nucleophile</scene> <ref>PMID:8263917</ref>. Water molecules are shown as red spheres. | The biological assembly of GLDH from ''Clostridium symbiosum'' is <scene name='49/490918/Cv/6'>homohexamer</scene>. The <scene name='49/490918/Cv/7'>glutamate binding pocket of GLDH</scene> is in a cleft between the two domains of the enzyme with <scene name='49/490918/Cv/8'>residue D165 serving as a general base and a protein-bound water molecule as the attacking nucleophile</scene> <ref>PMID:8263917</ref>. Water molecules are shown as red spheres. | ||
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| + | ==3D structures of glutamate dehydrogenase== | ||
| + | [[Glutamate dehydrogenase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of glutamate dehydrogenase== | ==3D structures of glutamate dehydrogenase== | ||
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*Glutamate dehydrogenase | *Glutamate dehydrogenase | ||
| + | **[[1l1f]] – hGLDH1 – human<br /> | ||
| + | **[[1nr1]], [[6dqg]] – hGLDH1 (mutant)<br /> | ||
| + | **[[6g2u]] – hGLDH2<br /> | ||
| + | **[[1nr7]] – bGLDH – bovine<br /> | ||
| + | **[[6dhn]], [[6dhl]], [[3jcg]] – bGLDH1<br /> | ||
| + | **[[5k12]] – bGLDH1 – Cryo-EM<br /> | ||
**[[1gtm]] – GLDH – ''Pyrococcus furiosus''<br /> | **[[1gtm]] – GLDH – ''Pyrococcus furiosus''<br /> | ||
**[[1hrd]] – CsGLDH – ''Clostridium symbiosum''<br /> | **[[1hrd]] – CsGLDH – ''Clostridium symbiosum''<br /> | ||
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**[[1b26]] – TmGLDH – ''Thermotoga maritima''<br /> | **[[1b26]] – TmGLDH – ''Thermotoga maritima''<br /> | ||
**[[1b3b]], [[2tmg]] - TmGLDH (mutant)<br /> | **[[1b3b]], [[2tmg]] - TmGLDH (mutant)<br /> | ||
| - | **[[1l1f]] – hGLDH1 – human<br /> | ||
| - | **[[1nr1]] – hGLDH1 (mutant)<br /> | ||
| - | **[[1nr7]] – bGLDH – bovine<br /> | ||
| - | **[[6dhn]], [[6dhl]], [[3jcg]] – bGLDH1<br /> | ||
| - | **[[5k12]] – bGLDH1 – Cryo-EM<br /> | ||
**[[2bma]] – PfGLDH – ''Plasmodium falciparum''<br /> | **[[2bma]] – PfGLDH – ''Plasmodium falciparum''<br /> | ||
**[[3r3j]] - PfGLDH (mutant)<br /> | **[[3r3j]] - PfGLDH (mutant)<br /> | ||
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**[[6dhm]] - bGLDH + NAD + GTP + glutamate <br /> | **[[6dhm]] - bGLDH + NAD + GTP + glutamate <br /> | ||
**[[3ete]], [[3etg]] - bGLDH + NADP + GTP + inhibitor + glutamate <br /> | **[[3ete]], [[3etg]] - bGLDH + NADP + GTP + inhibitor + glutamate <br /> | ||
| - | **[[1nqt]] - bGLDH + ADP<br /> | + | **[[1nqt]], [[6dhk]] - bGLDH + ADP<br /> |
**[[6dhq]] - bGLDH + NADP + epicatechin-3-gallate<br /> | **[[6dhq]] - bGLDH + NADP + epicatechin-3-gallate<br /> | ||
**[[3jd0]] – bGLDH1 + GTP<br /> | **[[3jd0]] – bGLDH1 + GTP<br /> | ||
Revision as of 08:39, 11 July 2019
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3D structures of glutamate dehydrogenase
Updated on 11-July-2019
References
- ↑ FRIEDEN C. GLUTAMATE DEHYDROGENASE. VI. SURVEY OF PURINE NUCLEOTIDE AND OTHER EFFECTS ON THE ENZYME FROM VARIOUS SOURCES. J Biol Chem. 1965 May;240:2028-35. PMID:14299621
- ↑ Smith TJ, Schmidt T, Fang J, Wu J, Siuzdak G, Stanley CA. The structure of apo human glutamate dehydrogenase details subunit communication and allostery. J Mol Biol. 2002 May 3;318(3):765-77. PMID:12054821 doi:10.1016/S0022-2836(02)00161-4
- ↑ Van Waes L, Lieber CS. Glutamate dehydrogenase: a reliable marker of liver cell necrosis in the alcoholic. Br Med J. 1977 Dec 10;2(6101):1508-10. PMID:589307
- ↑ Yorifuji T, Muroi J, Uematsu A, Hiramatsu H, Momoi T. Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics. Hum Genet. 1999 Jun;104(6):476-9. PMID:10453735
- ↑ Stillman TJ, Baker PJ, Britton KL, Rice DW. Conformational flexibility in glutamate dehydrogenase. Role of water in substrate recognition and catalysis. J Mol Biol. 1993 Dec 20;234(4):1131-9. PMID:8263917 doi:http://dx.doi.org/10.1006/jmbi.1993.1665
