Glutathione S-transferase

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== Structural highlights ==
== Structural highlights ==
The <scene name='52/524296/Cv/4'>glutathione binding site is at the N-terminal of GST</scene><ref>PMID:9367777</ref>.
The <scene name='52/524296/Cv/4'>glutathione binding site is at the N-terminal of GST</scene><ref>PMID:9367777</ref>.
 +
 +
==3D structures of glutathione S-transferase==
 +
[[Glutathione S-transferase 3D structures]]
 +
</StructureSection>
</StructureSection>
==3D structures of glutathione S-transferase==
==3D structures of glutathione S-transferase==
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*GST
*GST
-
**[[4hz4]] – GST – ''Actinobacillus pleuropneumoniae''<br />
 
**[[1gsb]], [[1gsc]] – rGST – rat<br />
**[[1gsb]], [[1gsc]] – rGST – rat<br />
 +
**[[3vwx]] – GST 6B (mutant) – fly<br />
 +
**[[3f6f]] – DmGST – Drosophila melanogaster <br />
 +
**[[3w8s]] – hoGST 3 – hookworm<br />
 +
**[[4ofm]], [[4ofn]], [[4oft]] – hoGST 1<br />
 +
**[[3ay8]], [[4e8e]] - siGST – silkworm<br />
 +
**[[1aw9]] - cGST III – corn<br />
 +
**[[4j2f]] – GST – castor bean<br />
 +
**[[3erf]] - yGST II – yeast<br />
**[[3ubk]] – LiGST – ''Leptospira interrogans''<br />
**[[3ubk]] – LiGST – ''Leptospira interrogans''<br />
**[[3uap]] - McGST – ''Methylococcus capsulatus''<br />
**[[3uap]] - McGST – ''Methylococcus capsulatus''<br />
-
**[[1aw9]] - cGST III – corn<br />
 
**[[1okt]], [[4zxg]] – PfGST – ''Plasmodium falciparum''<br />
**[[1okt]], [[4zxg]] – PfGST – ''Plasmodium falciparum''<br />
**[[3fr6]] - PfGST (mutant) <br />
**[[3fr6]] - PfGST (mutant) <br />
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**[[2fno]], [[3lq7]] - AtGST – ''Agrobacterium tumefaciens''<br />
**[[2fno]], [[3lq7]] - AtGST – ''Agrobacterium tumefaciens''<br />
**[[2on7]] – NaGST-1 – ''Necator americanus''<br />
**[[2on7]] – NaGST-1 – ''Necator americanus''<br />
-
**[[3erf]] - yGST II – yeast<br />
 
**[[3f6f]] – DmGST – ''Drosophila melanogaster''<br />
**[[3f6f]] – DmGST – ''Drosophila melanogaster''<br />
**[[3lxt]] - PsfGST – ''Pseudomonas fluorescens''<br />
**[[3lxt]] - PsfGST – ''Pseudomonas fluorescens''<br />
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**[[1jlw]] - AcGST - ''Anopheles cracens''<br />
**[[1jlw]] - AcGST - ''Anopheles cracens''<br />
**[[4f03]] - PcGST - ''Phanerochaete chrysosporium''<br />
**[[4f03]] - PcGST - ''Phanerochaete chrysosporium''<br />
-
**[[3vwx]] – GST 6B (mutant) – fly<br />
 
-
**[[3w8s]] – hoGST 3 – hookworm<br />
 
-
**[[4ofm]], [[4ofn]], [[4oft]] – hoGST 1<br />
 
-
**[[4j2f]] – GST – castor bean<br />
 
**[[4mp4]] – GST – ''Acinetobacter baumannii''<br />
**[[4mp4]] – GST – ''Acinetobacter baumannii''<br />
**[[4o7h]] – GST – ''Rhodospirillum rubrum''<br />
**[[4o7h]] – GST – ''Rhodospirillum rubrum''<br />
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**[[4pts]] – GST – ''Gordonia bronchialis''<br />
**[[4pts]] – GST – ''Gordonia bronchialis''<br />
**[[5el8]], [[5ela]], [[5elg]] - AtGST DHAR1 – ''Arabidopsis thaliana''<br />
**[[5el8]], [[5ela]], [[5elg]] - AtGST DHAR1 – ''Arabidopsis thaliana''<br />
 +
**[[4hz4]] – GST – ''Actinobacillus pleuropneumoniae''<br />
*''GST binary complex with GSH''
*''GST binary complex with GSH''
 +
**[[1m0u]], [[3gh6]] - DmGST + GSH<BR />
 +
**[[5an1]] – GST + GSH – shrimp<br />
 +
**[[1oyj]] - GST + GSH - rice<br />
 +
**[[3ibh]] - yGST II + GSH<BR />
**[[2x64]] – GST + GSH – ''Xylella fastidiosa''<br />
**[[2x64]] – GST + GSH – ''Xylella fastidiosa''<br />
**[[4hz2]] - GST + GSH - ''Xanthobacter autotrophicus''<br />
**[[4hz2]] - GST + GSH - ''Xanthobacter autotrophicus''<br />
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**[[1fhe]], [[2fhe]] - FhGST + GSH – ''Fasciola hepatica''<br />
**[[1fhe]], [[2fhe]] - FhGST + GSH – ''Fasciola hepatica''<br />
**[[1pmt]], [[2pmt]] - GST + GSH – ''Proteus mirabilis''<br />
**[[1pmt]], [[2pmt]] - GST + GSH – ''Proteus mirabilis''<br />
-
**[[1m0u]], [[3gh6]] - DmGST + GSH<BR />
 
**[[1oe7]], [[1oe8]] - ShGST + GSH – ''Schistosoma haematobium''<br />
**[[1oe7]], [[1oe8]] - ShGST + GSH – ''Schistosoma haematobium''<br />
**[[1u3i]] - GST + GSH - ''Schistosoma mansoni''<br />
**[[1u3i]] - GST + GSH - ''Schistosoma mansoni''<br />
-
**[[1oyj]] - GST + GSH - rice<br />
 
**[[1u87]], [[1gne]] - SjGST + GSH<BR />
**[[1u87]], [[1gne]] - SjGST + GSH<BR />
**[[2dsa]], [[2gdr]] - GST + GSH – ''Burkholderia xenovorans''<br />
**[[2dsa]], [[2gdr]] - GST + GSH – ''Burkholderia xenovorans''<br />
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**[[2nto]] - OaGST + GSH – ''Ochrobactrum anthropi''<br />
**[[2nto]] - OaGST + GSH – ''Ochrobactrum anthropi''<br />
**[[2pvq]] - OaGST (mutant) + GSH<BR />
**[[2pvq]] - OaGST (mutant) + GSH<BR />
-
**[[3ibh]] - yGST II + GSH<BR />
 
**[[3fr9]] - PfGST + GSH<BR />
**[[3fr9]] - PfGST + GSH<BR />
**[[3m3m]] - PsfGST + GSH<BR />
**[[3m3m]] - PsfGST + GSH<BR />
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**[[4nax]] – GST N terminal + GSH – ''Pseudomonas putida''<br />
**[[4nax]] – GST N terminal + GSH – ''Pseudomonas putida''<br />
**[[4pua]] – GST + GSH – ''Streptococcus pneumoniae''<br />
**[[4pua]] – GST + GSH – ''Streptococcus pneumoniae''<br />
-
**[[5an1]] – GST + GSH – shrimp<br />
 
**[[5lol]] - AtGST DHAR2 + GSH<br />
**[[5lol]] - AtGST DHAR2 + GSH<br />
*''GST binary complex''
*''GST binary complex''
-
**[[3ubl]] - LiGST + GSH derivative<br />
+
**[[1aqv]] - hGST + GSH derivative – human<br />
**[[2gsq]] – sqGST + GSH derivative – squid<br />
**[[2gsq]] – sqGST + GSH derivative – squid<br />
-
**[[2gst]], [[3gst]], [[4gst]], [[5gst]], [[1gss]] - rGST + GSH derivative<br />
+
**[[2gst]], [[3gst]], [[4gst]], [[5gst]], [[1gss]]. [[1mtc]] - rGST + GSH derivative<br />
-
**[[1gnw]] - AtGST + GSH derivative <br />
+
**[[1bye]] - cGST I + herbicide <br />
 +
**[[1axd]] – cGST I + lactoyl-GSH<BR />
 +
**[[3erg]] - yGST II + GSH derivative<br />
 +
**[[3qmz]] - yGST + dynein heavy chain<br />
 +
**[[1gnw]], [[2ycd]] - AtGST + GSH derivative <br />
**[[5a4u]] - AtGST + indole aldehyde<br />
**[[5a4u]] - AtGST + indole aldehyde<br />
**[[5a4v]], [[5a4w]] - AtGST + quercetin<br />
**[[5a4v]], [[5a4w]] - AtGST + quercetin<br />
**[[5a5k]] - AtGST + camalexin<br />
**[[5a5k]] - AtGST + camalexin<br />
-
**[[1aqv]] - hGST + GSH derivative – human<br />
+
**[[1bx9]] - AtGST + herbicide<br />
**[[1gtb]], [[1gta]] - SjGST + praziquantel<br />
**[[1gtb]], [[1gta]] - SjGST + praziquantel<br />
-
**[[1m99]], [[1m9a]], [[1m9b]] - SjGST + GSH derivative<br />
+
**[[1m99]], [[1m9a]], [[1m9b]]. [[1ua5]] - SjGST + GSH derivative<br />
 +
**[[1u88]] - SjGST (mutant) + GSH derivative<br />
**[[1q4j]], [[2aaw]], [[3frc]] - PfGST + GSH derivative<br />
**[[1q4j]], [[2aaw]], [[3frc]] - PfGST + GSH derivative<br />
**[[3fr3]] - PfGST (mutant) + GSH derivative<br />
**[[3fr3]] - PfGST (mutant) + GSH derivative<br />
-
**[[1bx9]] - AtGST + herbicide<br />
 
-
**[[1bye]] - cGST I + herbicide <br />
 
-
**[[1axd]] – cGST I + lactoyl-GSH<BR />
 
**[[1a0f]], [[1n2a]] - GST + GSH derivative – ''Eschericia coli''<br />
**[[1a0f]], [[1n2a]] - GST + GSH derivative – ''Eschericia coli''<br />
-
**[[1f2e]] - GST + GSH derivative – ''Sphingomonas paucimobilis''<br />
+
**[[1f2e]] - GST + GSH derivative – ''Sphingomonas paucimobilis''<br />
-
**[[1mtc]] - rGST + GSH derivative<br />
+
-
**[[1ua5]] - SjGST + GSH derivative<br />
+
-
**[[1u88]] - SjGST (mutant) + GSH derivative<br />
+
-
**[[3erg]] - yGST II + GSH derivative<br />
+
-
**[[3qmz]] - yGST + dynein heavy chain<br />
+
-
**[[2ycd]] - AtGST + GSH derivative<br />
+
**[[4yav]] - GST + GSH derivative – ''Sphingobium''<br />
**[[4yav]] - GST + GSH derivative – ''Sphingobium''<br />
 +
**[[3ubl]] - LiGST + GSH derivative<br />
*GST α class
*GST α class

Revision as of 06:43, 14 July 2019

Glutathione S-tansferase complex with glutathione (PDB entry 1fhe)

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3D structures of glutathione S-transferase

Updated on 14-July-2019

References

  1. ↑ Oakley A. Glutathione transferases: a structural perspective. Drug Metab Rev. 2011 May;43(2):138-51. doi: 10.3109/03602532.2011.558093. Epub, 2011 Mar 23. PMID:21428697 doi:http://dx.doi.org/10.3109/03602532.2011.558093
  2. ↑ Rossjohn J, Feil SC, Wilce MC, Sexton JL, Spithill TW, Parker MW. Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase. J Mol Biol. 1997 Nov 7;273(4):857-72. PMID:9367777 doi:10.1006/jmbi.1997.1338

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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