Glycolate oxidase

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) of an α-hydroxy acid oxidase and its <scene name='48/486364/Cv/9'>active site contains the cofactor FMN</scene><ref>PMID:18215067</ref>. Water molecules are shown as red spheres.
) of an α-hydroxy acid oxidase and its <scene name='48/486364/Cv/9'>active site contains the cofactor FMN</scene><ref>PMID:18215067</ref>. Water molecules are shown as red spheres.
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==3D structures of glycolate oxidase==
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[[Glycolate oxidase 3D structures]]
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</StructureSection>
</StructureSection>
==3D structures of glycolate oxidase==
==3D structures of glycolate oxidase==
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*Glycolate oxidase
*Glycolate oxidase
-
**[[1gyl]] – sGOX – spinach<br />
+
**[[1tb3]] – rGOX3 + FMN – rat<br />
-
**[[2nzl]] – hGOX1 – human<br />
+
**[[1gyl]], [[1gox]] – sGOX + FMN – spinach<br />
 +
**[[5zbn]] – NbGOX – ''Nicotiana benthamiana''<br />
 +
**[[5zbm]] – NbGOX + FMN <br />
**[[2yvs]] – GOX GLCE subunit – ''Thermus thermophilus''<br />
**[[2yvs]] – GOX GLCE subunit – ''Thermus thermophilus''<br />
-
**[[1tb3]] – rGOX3 – rat
 
*Glycolate oxidase complex
*Glycolate oxidase complex
-
**[[1al8]], [[1al7]] – sGOX + inhibitor<br />
+
**[[2rdu]], [[2nzl]] – hGOX1 + FMN + glyoxylate<br />
-
**[[2rdu]] – hGOX1 + glyoxylate<br />
+
**[[2rdw]] – hGOX1 + FMN + sulfate<br />
-
**[[2rdw]] – hGOX1 + sulfate<br />
+
**[[6gmb]] – hGOX1 + FMN + glycolate<br />
-
**[[2w0u]], [[2rdt]] – hGOX1 + inhibitor<br />
+
**[[6gmc]], [[2w0u]], [[2rdt]] – hGOX1 + FMN + thiadiazole derivative<br />
-
**[[3sgz]] – rGOX2 + inhibitor<br />
+
**[[5qib]], [[5qid]], [[6qif]] – hGOX1 + FMN + pyrimidine derivative<br />
 +
**[[5qic]] – hGOX1 + FMN + piperazine derivative<br />
 +
**[[5qie]] – hGOX1 + FMN + aniline derivative<br />
 +
**[[6qig]], [[6qih]] – hGOX1 + FMN + imidazole derivative<br />
 +
**[[3sgz]] – rGOX2 + FMN + thiadiazole derivative<br />
 +
**[[1al8]], [[1al7]] – sGOX + FMN + thiadiazole derivative<br />
**[[3giy]] – GOX1/(S)-mandelate dehydrogenase + MES – ''Pseudomonas putida''
**[[3giy]] – GOX1/(S)-mandelate dehydrogenase + MES – ''Pseudomonas putida''
}}
}}

Revision as of 09:51, 15 July 2019

Human glycolate oxidase 1 complex with glyoxylate and FMN (PDB entry 2rdu)

Drag the structure with the mouse to rotate

3D structures of glycolate oxidase

Updated on 15-July-2019

References

  1. ↑ Rojas CM, Senthil-Kumar M, Wang K, Ryu CM, Kaundal A, Mysore KS. Glycolate oxidase modulates reactive oxygen species-mediated signal transduction during nonhost resistance in Nicotiana benthamiana and Arabidopsis. Plant Cell. 2012 Jan;24(1):336-52. doi: 10.1105/tpc.111.093245. Epub 2012 Jan 27. PMID:22286136 doi:http://dx.doi.org/10.1105/tpc.111.093245
  2. ↑ Frishberg Y, Zeharia A, Lyakhovetsky R, Bargal R, Belostotsky R. Mutations in HAO1 encoding glycolate oxidase cause isolated glycolic aciduria. J Med Genet. 2014 Aug;51(8):526-9. doi: 10.1136/jmedgenet-2014-102529. Epub 2014 , Jul 4. PMID:24996905 doi:http://dx.doi.org/10.1136/jmedgenet-2014-102529
  3. ↑ Murray MS, Holmes RP, Lowther WT. Active Site and Loop 4 Movements within Human Glycolate Oxidase: Implications for Substrate Specificity and Drug Design. Biochemistry. 2008 Feb 26;47(8):2439-49. Epub 2008 Jan 24. PMID:18215067 doi:10.1021/bi701710r

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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