Glycosyltransferase

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Line 33: Line 33:
**[[1d7f]] - BaCGT (mutant) – ''Bacillus''<br />
**[[1d7f]] - BaCGT (mutant) – ''Bacillus''<br />
**[[1pam]] - BaCGT<br />
**[[1pam]] - BaCGT<br />
-
**[[4jcl]] - CGT – ''Paenibacillus macerans''<br />
+
**[[4jcl]] - PmCGT – ''Paenibacillus macerans''<br />
 +
**[[6aij]] - PmCGT (mutant) <br />
*''CGT binary complexes''
*''CGT binary complexes''
Line 106: Line 107:
*UDP GT
*UDP GT
-
**[[5v2j]], [[5v2k]], [[5u6s]] – AtGT + UDP + laminaribiose + Br-benzoate<br />
 
-
**[[5u6n]], [[5u6m]] – AtGT + UDP + laminaribiose + salicilate<br />
 
**[[5tme]], [[5tmb]] – rGT OS 79 + UDP - rice <br />
**[[5tme]], [[5tmb]] – rGT OS 79 + UDP - rice <br />
**[[6bk0]], [[6bk1]], [[6bk2]] - rGT OS 79 (mutant) + UDP <br />
**[[6bk0]], [[6bk1]], [[6bk2]] - rGT OS 79 (mutant) + UDP <br />
Line 113: Line 112:
**[[5xvm]] - yGT 51 – yeast<br />
**[[5xvm]] - yGT 51 – yeast<br />
**[[5gl5]] - yGT 51 + UDP-glucose <br />
**[[5gl5]] - yGT 51 + UDP-glucose <br />
 +
**[[5v2j]], [[5v2k]], [[5u6s]] – AtGT + UDP + laminaribiose + Br-benzoate<br />
 +
**[[5u6n]], [[5u6m]] – AtGT + UDP + laminaribiose + salicilate<br />
 +
**[[6o86]], [[6o87]] – SrGT + UDP – ''Stevia rebaudiana''<br />
 +
**[[6o88]] – SrGT + UDP + revaudioside<br />
 +
 +
*C-GT
 +
 +
**[[6jtd]] – GT + UDP – Trollius chinensis<br />
*Flavonoid GT
*Flavonoid GT
Line 133: Line 140:
**[[6bar]] – TtGT RODA – ''Thermus thermophilus''<br />
**[[6bar]] – TtGT RODA – ''Thermus thermophilus''<br />
**[[6bas]] – TtGT RODA (mutant) <br />
**[[6bas]] – TtGT RODA (mutant) <br />
 +
**[[3hzs]], [[3vmq]], [[5zzk]] – SaGT - ''Staphylococcus aureus''<br />
 +
**[[6ftb]] – SaGT + moenomycin <br />
*Various GT
*Various GT
Line 138: Line 147:
**[[2iuy]], [[2iv3]] – SvGT – ''Stretptomyces viridochromogenes''
**[[2iuy]], [[2iv3]] – SvGT – ''Stretptomyces viridochromogenes''
-
**[[3hzs]], [[3vmq]] – SaGT – ''Staphylococcus aureus''<br />
 
**[[2jjm]] - BaGT – ''Bacillus anthracis''<br />
**[[2jjm]] - BaGT – ''Bacillus anthracis''<br />
**[[3oy2]] – PcvGT – ''Paramecium chiorela virus''<br />
**[[3oy2]] – PcvGT – ''Paramecium chiorela virus''<br />
Line 165: Line 173:
**[[5du2]] - GT – ''Actinomadura verrucosospora''<br />
**[[5du2]] - GT – ''Actinomadura verrucosospora''<br />
**[[5a01]] – DmO-GT catalytic domain (mutant) – ''Drosophila melanogaster''<br />
**[[5a01]] – DmO-GT catalytic domain (mutant) – ''Drosophila melanogaster''<br />
 +
**[[6p61]] – GT – ''Leptospira borgpetersenii''<br />
*Various GT complexes
*Various GT complexes
Line 197: Line 206:
*β-1,4-galactosyltransferase 1 (BGT)
*β-1,4-galactosyltransferase 1 (BGT)
 +
**[[2fy7]] - hBGT 1 catalytic domain (mutant) <br />
**[[1fgx]] - bBGT 1 catalytic domain – bovine<br />
**[[1fgx]] - bBGT 1 catalytic domain – bovine<br />
**[[1pzt]], [[4krv]] - bBGT 1 catalytic domain (mutant) <br />
**[[1pzt]], [[4krv]] - bBGT 1 catalytic domain (mutant) <br />
-
**[[2fy7]] - hBGT 1 catalytic domain (mutant) <br />
 
**[[3lw6]] - DmBGT 7 catalytic domain (mutant)
**[[3lw6]] - DmBGT 7 catalytic domain (mutant)
*''BGT 1 binary complexes''
*''BGT 1 binary complexes''
 +
**[[1oqm]] - bBGT catalytic domain + UDP-N-acetylgalactosamine<br />
 +
**[[2fya]] - hBGT 1 catalytic domain (mutant) + Mn<br />
 +
**[[4ee3]], [[4ee4]], [[4ee5]], [[4eea]], [[4eeg]], [[4eem]], [[4eeo]] - hBGT 1 catalytic domain (mutant) + polysaccharide<br />
**[[1fr8]], [[1o0r]] - bBGT 1 catalytic domain + UDP-galactose<br />
**[[1fr8]], [[1o0r]] - bBGT 1 catalytic domain + UDP-galactose<br />
**[[1tw5]] - bBGT catalytic domain (mutant) + chitobiose<br />
**[[1tw5]] - bBGT catalytic domain (mutant) + chitobiose<br />
Line 210: Line 222:
**[[1o23]] - bBGT catalytic domain + UDP-glucose<br />
**[[1o23]] - bBGT catalytic domain + UDP-glucose<br />
**[[1oqm]] - bBGT catalytic domain + UDP-N-acetylgalactosamine<br />
**[[1oqm]] - bBGT catalytic domain + UDP-N-acetylgalactosamine<br />
-
**[[2fya]] - hBGT 1 catalytic domain (mutant) + Mn<br />
 
-
**[[4ee3]], [[4ee4]], [[4ee5]], [[4eea]], [[4eeg]], [[4eem]], [[4eeo]] - hBGT 1 catalytic domain (mutant) + polysaccharide<br />
 
*''BGT 1 ternary complexes''
*''BGT 1 ternary complexes''
-
**[[1nhe]], [[1nkh]] - bBGT 1 catalytic domain + UDP + α-lactalbumin<br />
 
-
**[[1yro]] - bBGT 1 catalytic domain (mutant) + UDP-galactose + α-lactalbumin<br />
 
-
**[[1nwg]] - bBGT catalytic domain + N-butanoyl-glucoamine + α-lactalbumin<br />
 
-
**[[1nmm]], [[1nqi]], [[1pzy]], [[1o7q]] - bBGT 1 catalytic domain + UDP + GlcNAc<br />
 
**[[2fyb]] - hBGT 1 catalytic domain (mutant) + Mn + UDP<br />
**[[2fyb]] - hBGT 1 catalytic domain (mutant) + Mn + UDP<br />
**[[2ae7]]- hBGT 1 catalytic domain + UDP + pentasaccharide<br />
**[[2ae7]]- hBGT 1 catalytic domain + UDP + pentasaccharide<br />
Line 226: Line 232:
**[[2fyd]] - hBGT 1 catalytic domain + UDP-GlcNAc + Mn + α-lactalbumin<br /> (mutant) + glucose<br />
**[[2fyd]] - hBGT 1 catalytic domain + UDP-GlcNAc + Mn + α-lactalbumin<br /> (mutant) + glucose<br />
**[[2ah9]] - hBGT 1 catalytic domain + UDP + chitotriose<br />
**[[2ah9]] - hBGT 1 catalytic domain + UDP + chitotriose<br />
 +
**[[1nhe]], [[1nkh]] - bBGT 1 catalytic domain + UDP + α-lactalbumin<br />
 +
**[[1yro]] - bBGT 1 catalytic domain (mutant) + UDP-galactose + α-lactalbumin<br />
 +
**[[1nwg]] - bBGT catalytic domain + N-butanoyl-glucoamine + α-lactalbumin<br />
 +
**[[1nmm]], [[1nqi]], [[1pzy]], [[1o7q]] - bBGT 1 catalytic domain + UDP + GlcNAc<br />
*β-1,4-galactosyltransferase 7 (BGT)
*β-1,4-galactosyltransferase 7 (BGT)
-
**[[3lw6]] - DmBGT 7 catalytic domain (mutant)<br />
 
**[[1tvy]], [[1tw1]], [[4lw3]] - bBGT 7 catalytic domain (mutant) + UDP-galactose<br />
**[[1tvy]], [[1tw1]], [[4lw3]] - bBGT 7 catalytic domain (mutant) + UDP-galactose<br />
**[[4irq]], [[4irp]] - bBGT 7 catalytic domain + UDP<br />
**[[4irq]], [[4irp]] - bBGT 7 catalytic domain + UDP<br />
**[[4lw6]] - bBGT 7 catalytic domain + xylobiose<br />
**[[4lw6]] - bBGT 7 catalytic domain + xylobiose<br />
**[[4m4k]] - bBGT 7 catalytic domain (mutant) + UDP-galactose + xylobiose<br />
**[[4m4k]] - bBGT 7 catalytic domain (mutant) + UDP-galactose + xylobiose<br />
 +
**[[3lw6]] - DmBGT 7 catalytic domain (mutant)<br />
*α-1,3-galactosyltransferase (AGT)
*α-1,3-galactosyltransferase (AGT)
 +
**[[1vzu]], [[1vzx]], [[2i7b]] - hAGT catalytic domain (mutant)<br />
 +
**[[2i7b]] - hAGT catalytic domain (mutant)<br />
**[[1g8o]], [[1fg5]], [[2jco]] - bAGT catalytic domain<br />
**[[1g8o]], [[1fg5]], [[2jco]] - bAGT catalytic domain<br />
**[[2jcl]] – bAGT catalytic domain (mutant) <br />
**[[2jcl]] – bAGT catalytic domain (mutant) <br />
-
**[[1vzu]], [[1vzx]], [[2i7b]] - hAGT catalytic domain (mutant)<br />
 
-
**[[2i7b]] - hAGT catalytic domain (mutant)
 
*''AGT binary complexes''
*''AGT binary complexes''
 +
**[[1ziz]], [[1zjp]] - hAGT catalytic domain + galactose<br />
 +
**[[1zj0]] - hAGT catalytic domain + lactose<br />
 +
**[[1zj1]] - hAGT catalytic domain + N-acetyl lactosamine<br />
 +
**[[1zj2]], [[1zj3]] - hAGT catalytic domain + trisaccharide<br />
 +
**[[2a8u]], [[2a8w]] - hAGT catalytic domain + methyl lactoside<br />
**[[1g93]], [[1gx0]] - bAGT catalytic domain + UDP-galactose<br />
**[[1g93]], [[1gx0]] - bAGT catalytic domain + UDP-galactose<br />
**[[1k4v]] - bAGT catalytic domain + UDP<br />
**[[1k4v]] - bAGT catalytic domain + UDP<br />
Line 251: Line 266:
**[[2vs4]], [[2vs5]], [[2vxl]], [[2vxm]], [[2vs3]] - bAGT catalytic domain (mutant) + UDP-galactose<br />
**[[2vs4]], [[2vs5]], [[2vxl]], [[2vxm]], [[2vs3]] - bAGT catalytic domain (mutant) + UDP-galactose<br />
**[[2vs3]] - bAGT catalytic domain + UDP-galactose<br />
**[[2vs3]] - bAGT catalytic domain + UDP-galactose<br />
-
**[[1ziz]], [[1zjp]] - hAGT catalytic domain + galactose<br />
 
-
**[[1zj0]] - hAGT catalytic domain + lactose<br />
 
-
**[[1zj1]] - hAGT catalytic domain + N-acetyl lactosamine<br />
 
-
**[[1zj2]], [[1zj3]] - hAGT catalytic domain + trisaccharide<br />
 
-
**[[2a8u]], [[2a8w]] - hAGT catalytic domain + methyl lactoside<br />
 
*''AGT ternary complexes''
*''AGT ternary complexes''
 +
**[[1r7u]], [[1r7x]] - hAGT catalytic domain + inhibitor + fucose<br />
 +
**[[1r80]] - hAGT catalytic domain + UDP + inhibitor + fucose<br />
 +
**[[1r82]] - hAGT catalytic domain + UDP-galactose + inhibitor + fucose<br />
**[[1gwv]] - bAGT catalytic domain + UDP + lactose<br />
**[[1gwv]] - bAGT catalytic domain + UDP + lactose<br />
**[[2jck]] - bAGT catalytic domain (mutant) + UDP + Mn<br />
**[[2jck]] - bAGT catalytic domain (mutant) + UDP + Mn<br />
Line 265: Line 278:
**[[1gx4]] - bAGT catalytic domain + UDP + N-acetyl lactosamine<br />
**[[1gx4]] - bAGT catalytic domain + UDP + N-acetyl lactosamine<br />
**[[1gww]] - bAGT catalytic domain + UDP + glucose<br />
**[[1gww]] - bAGT catalytic domain + UDP + glucose<br />
-
**[[1r7u]], [[1r7x]] - hAGT catalytic domain + inhibitor + fucose<br />
 
-
**[[1r80]] - hAGT catalytic domain + UDP + inhibitor + fucose<br />
 
-
**[[1r82]] - hAGT catalytic domain + UDP-galactose + inhibitor + fucose<br />
 
*Fucosylglycoprotein 3-AGT (GTB) or histo-blood group ABO system transferase
*Fucosylglycoprotein 3-AGT (GTB) or histo-blood group ABO system transferase
Line 277: Line 287:
**[[4gbp]], [[4frq]], [[4fqw]], [[4fre]], [[4frh]], [[4frl]], [[4frm]], [[4fro]], [[4frp]], [[3sxa]], [[3sxb]] – hGTB + UDP-galactose<br />
**[[4gbp]], [[4frq]], [[4fqw]], [[4fre]], [[4frh]], [[4frl]], [[4frm]], [[4fro]], [[4frp]], [[3sxa]], [[3sxb]] – hGTB + UDP-galactose<br />
**[[4fra]], [[4frb]], [[4frd]], [[3zgf]], [[3zgg]], [[3v0l]], [[3v0m]], [[3v0n]], [[3v0o]], [[3ioi]] – hGTB (mutant) + UDP-galactose<br />
**[[4fra]], [[4frb]], [[4frd]], [[3zgf]], [[3zgg]], [[3v0l]], [[3v0m]], [[3v0n]], [[3v0o]], [[3ioi]] – hGTB (mutant) + UDP-galactose<br />
-
**[[5m79]], [[5m7a]] – hGT (mutant) + UMP<br />
+
**[[5m79]], [[5m7a]] – hGTB (mutant) + UMP<br />
**[[4y62]], [[4y63]], [[4y64]] - hGTB + amino acid analog<br />
**[[4y62]], [[4y63]], [[4y64]] - hGTB + amino acid analog<br />
**[[3u0x]] – hGTB + inhibitor<br />
**[[3u0x]] – hGTB + inhibitor<br />
Line 283: Line 293:
**[[2riy]] – hGTB + H-antigen acceptor<br />
**[[2riy]] – hGTB + H-antigen acceptor<br />
**[[1zi4]], [[1zi5]] - hGTB + H-antigen<br />
**[[1zi4]], [[1zi5]] - hGTB + H-antigen<br />
-
**[[3i0j]] – hGT Abo (mutant) + H-antigen<br />
+
**[[3i0j]] – hGTB Abo (mutant) + H-antigen<br />
**[[2rj1]], [[2rj6]] - hGTB (mutant) + UDP + H-antigen disaccharide<br />
**[[2rj1]], [[2rj6]] - hGTB (mutant) + UDP + H-antigen disaccharide<br />
**[[2rj8]] - hGTB + UDP + H-antigen disaccharide<br />
**[[2rj8]] - hGTB + UDP + H-antigen disaccharide<br />
Line 295: Line 305:
**[[5c8r]], [[5c4b]] - hGTB + UDP-glucose + deoxy-acceptor<br />
**[[5c8r]], [[5c4b]] - hGTB + UDP-glucose + deoxy-acceptor<br />
**[[5c4c]], [[5c4d]], [[5c4e]], [[5c4f]] - hGTB (mutant) + UDP-glucose + deoxy-acceptor<br />
**[[5c4c]], [[5c4d]], [[5c4e]], [[5c4f]] - hGTB (mutant) + UDP-glucose + deoxy-acceptor<br />
-
**[[3sx3]], [[3sx5]], [[3sx7]], [[3sx8]], [[3sxc]], [[3sxd]], [[3sxe]], [[3sxg]], [[1zhj]], [[1zjo]] - hAGT catalytic domain + galactose<br />
+
**[[3sx3]], [[3sx5]], [[3sx7]], [[3sx8]], [[3sxc]], [[3sxd]], [[3sxe]], [[3sxg]], [[1zhj]], [[1zjo]] - hGTB catalytic domain + galactose<br />
-
**[[1zi1]] - hAGT catalytic domain + lactose<br />
+
**[[1zi1]] - hGTB catalytic domain + lactose<br />
-
**[[1zi3]] - hAGT catalytic domain + acetylactosamine
+
**[[1zi3]] - hGTB catalytic domain + acetylactosamine
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:09, 16 July 2019

Cyclodextrin glycosyltransferase complex with substrate maltoheptaose, maltose and Ca+2 ions, 1cxh

Drag the structure with the mouse to rotate

3D structures of glycosyltransferase

Updated on 16-July-2019

References

  1. ↑ Williams GJ, Thorson JS. Natural product glycosyltransferases: properties and applications. Adv Enzymol Relat Areas Mol Biol. 2009;76:55-119. PMID:18990828
  2. ↑ Qasba PK, Ramakrishnan B, Boeggeman E. Structure and function of beta -1,4-galactosyltransferase. Curr Drug Targets. 2008 Apr;9(4):292-309. PMID:18393823
  3. ↑ Jadhav SK, Patel KA, Dholakia BB, Khan BM. Structural characterization of a flavonoid glycosyltransferase from Withania somnifera. Bioinformation. 2012;8(19):943-9. doi: 10.6026/97320630008943. Epub 2012 Oct 1. PMID:23144555 doi:http://dx.doi.org/10.6026/97320630008943
  4. ↑ Yoshida A, Kobayashi K, Manya H, Taniguchi K, Kano H, Mizuno M, Inazu T, Mitsuhashi H, Takahashi S, Takeuchi M, Herrmann R, Straub V, Talim B, Voit T, Topaloglu H, Toda T, Endo T. Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. Dev Cell. 2001 Nov;1(5):717-24. PMID:11709191
  5. ↑ Knegtel RM, Strokopytov B, Penninga D, Faber OG, Rozeboom HJ, Kalk KH, Dijkhuizen L, Dijkstra BW. Crystallographic studies of the interaction of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 with natural substrates and products. J Biol Chem. 1995 Dec 8;270(49):29256-64. PMID:7493956

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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