Glycosyltransferase

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</StructureSection>
</StructureSection>
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==3D structures of glycosyltransferase==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Cyclodextrin GT (CGT)
 
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**[[1cxi]], [[1cdg]], [[1cgt]], [[1cgu]] - BcCGT – ''Bacillus circulans''
 
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**[[1tcm]], [[4cgt]], [[7cgt]], [[1kck]], [[1kcl]], [[1ot1]], [[1ot2]], [[1pez]], [[1pj9]], [[1v3j]], [[1v3k]], [[1cgv]], [[1cgw]] - BcCGT (mutant)
 
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**[[1ciu]] – TtCGT – ''Thermoanaerobacterium thermosulfurigenes''
 
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**[[3bmv]], [[3bmw]] – TtCGT (mutant)<br />
 
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**[[1cyg]] – CGT – ''Geobacillus stearothermophilus''<br />
 
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**[[1d7f]] - BaCGT (mutant) – ''Bacillus''<br />
 
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**[[1pam]] - BaCGT<br />
 
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**[[4jcl]] - PmCGT – ''Paenibacillus macerans''<br />
 
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**[[6aij]] - PmCGT (mutant) <br />
 
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*''CGT binary complexes''
 
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**[[1cxe]], [[1cxh]] – BcCGT + substrate
 
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**[[1cxf]], [[5cgt]], [[8cgt]], [[9cgt]], [[1cxk]], [[1eo5]], [[1eo7]] - BcCGT (mutant) + substrate
 
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**[[3cgt]] - BcCGT (mutant) + β-cyclodextrin
 
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**[[1d3c]] - BcCGT (mutant) + γ-cyclodextrin
 
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**[[6cgt]] - BcCGT (mutant) + HOXA
 
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**[[2dij]], [[1dtu]] - BcCGT (mutant) + inhibitor
 
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**[[1cxl]] - BcCGT (mutant) + reaction intermediate
 
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**[[2cxg]], [[1ukq]] – BcCGT + acarbose-derivative
 
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**[[1uks]], [[1ukt]], [[1v3l]], [[1v3m]] – BcCGT (mutant) + acarbose-derivative<br />
 
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**[[1ded]] - BaCGT (mutant) + acarbose<br />
 
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**[[1i75]] – BaCGT + deoxyjirimycin<br />
 
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**[[1a47]] – TtCGT + inhibitor
 
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*Maltose GT
 
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**[[1gju]], [[1lwh]] – TmMCG – ''Thermotoga maritima''
 
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**[[1gjw]] – TmMCG + maltose
 
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**[[1lwj]] - TmMGT + acarbose
 
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*Human GT
 
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**[[1lz0]] – hGT A - hGT A catalytic domain + inhibitor
 
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**[[1r7y]], [[1r81]] - hGT A catalytic domain + inhibitor + UDP-derivative
 
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**[[1lz7]] – hGT B catalytic domain
 
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**[[1r7u]], [[1r7x]] - hGT B catalytic domain + inhibitor
 
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**[[1r80]], [[1r82]] - hGT B catalytic domain + inhibitor + UDP-derivative
 
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**[[1lzi]] – hGT A catalytic domain + UDP + H antigen acceptor
 
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**[[1lzj]] – hGT B catalytic domain + UDP + H antigen acceptor
 
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**[[1r7t]], [[1r7v]] - hGT ABO(H) + inhibitor
 
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**[[1wt0]], [[1wsz]], [[1wt3]], [[2o1f]], [[2o1g]], [[3i0c]], [[3i0h]], [[1xz6]], [[2i7b]] – hGT ABO(H) (mutant)
 
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**[[1wt1]], [[1wt2]], [[2o1h]], [[3i0d]], [[3i0i]], [[2y7a]] - hGT ABO(H) (mutant) + UDP
 
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**[[3i0e]], [[3i0j]] - hGT ABO(H) (mutant) + H-antigen
 
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**[[3i0f]], [[3i0k]] - hGT ABO(H) (mutant) + H-antigen + UDP
 
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**[[3i0g]], [[3i0l]] - hGT ABO(H) (mutant) + DA + UDP-Gal
 
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*Oleandomycin GT
 
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**[[2iya]], [[2iyf]], [[4m60]], [[4m7p]] – SaGT – ''Strepromyces antibioticus''<br />
 
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**[[4m83]] – SaGT + UDP + erythromycin<br />
 
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*Hydroquinone GT
 
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**[[2vce]] – AtGT – ''Arabidopsis thaliana''<br />
 
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**[[2vch]], [[2vg8]] – AtGT + UDP
 
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*UDP GT
 
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**[[5tme]], [[5tmb]] – rGT OS 79 + UDP - rice <br />
 
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**[[6bk0]], [[6bk1]], [[6bk2]] - rGT OS 79 (mutant) + UDP <br />
 
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**[[5tmd]], [[6bk3]] – rGT OS 79 + UDP derivative + trichothecene<br />
 
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**[[5xvm]] - yGT 51 – yeast<br />
 
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**[[5gl5]] - yGT 51 + UDP-glucose <br />
 
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**[[5v2j]], [[5v2k]], [[5u6s]] – AtGT + UDP + laminaribiose + Br-benzoate<br />
 
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**[[5u6n]], [[5u6m]] – AtGT + UDP + laminaribiose + salicilate<br />
 
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**[[6o86]], [[6o87]] – SrGT + UDP – ''Stevia rebaudiana''<br />
 
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**[[6o88]] – SrGT + UDP + revaudioside<br />
 
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*C-GT
 
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**[[6jtd]] – GT + UDP – Trollius chinensis<br />
 
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*Flavonoid GT
 
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**[[3hbf]] – MtGT + UDP + myricetin – ''Medicago truncatula''
 
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**[[3hbj]] - MtGT + UDP
 
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**[[2pq6]] - MtGT
 
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**[[2c1x]], [[2c1z]] – GT + UDP – ''Vitis vinifera''
 
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*Peptidoglycan GT
 
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**[[4jbf]], [[4ovd]] – ApGT – ''Atopobium parvulum''<br />
 
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**[[4mnr]] – GT D,D transpeptidase domain – ''Eggerthella lenta''<br />
 
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**[[4n1x]], [[4qjg]], [[4r1g]], [[4r23]], [[4r3j]], [[4ra7]] – ApGT penicillin-binding domain + penicillin<br />
 
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**[[4qjg]], [[4r0q]] – ApGT penicillin-binding domain + antibiotic<br />
 
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**[[5uy7]] – GT – ''Burkholderia ambifaria''<br />
 
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**[[6bar]] – TtGT RODA – ''Thermus thermophilus''<br />
 
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**[[6bas]] – TtGT RODA (mutant) <br />
 
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**[[3hzs]], [[3vmq]], [[5zzk]] – SaGT - ''Staphylococcus aureus''<br />
 
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**[[6ftb]] – SaGT + moenomycin <br />
 
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*Various GT
 
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**[[2iuy]], [[2iv3]] – SvGT – ''Stretptomyces viridochromogenes''
 
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**[[2jjm]] - BaGT – ''Bacillus anthracis''<br />
 
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**[[3oy2]] – PcvGT – ''Paramecium chiorela virus''<br />
 
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**[[3pnn]] – GT – ''Porphyromonas gingivalis''
 
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**[[2q3e]], [[3q3i]], [[3q3e]] – ApGT – ''Actinobacillus pleuropneumomiae''
 
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**[[1iir]] – AoUDP-GT – ''Amycolatopsis orientalis''
 
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**[[3h4i]], [[3h4t]] – GT chimera
 
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**[[1cwy]] – GT – ''Thermus aquaticus''
 
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**[[2iv7]], [[2iw1]], [[4rap]] – EcGT - ''Escherichia coli''<br />
 
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**[[4xyw]] – EcGT (mutant) <br />
 
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**[[2xci]] – AaGT – ''Aquifex aeolicus''
 
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**[[3ia7]] – MeGT Calg4 – ''Micromonospora echinospora''
 
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**[[3otk]] – GT catalytic domain - mouse<br />
 
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**[[4ayl]] - BoGT – ''Bacterioides ovatus''<br />
 
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**[[4an4]], [[4amb]], [[4amg]] – GT Snogd – ''Streptomyces nogalater''<br />
 
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**[[3wad]] – ShGT – ''Streptomyces halstedii''<br />
 
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**[[4pqg]] – GT- ''Streptococcus pneumoniae''<br />
 
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**[[5du2]] - GT – ''Actinomadura verrucosospora''<br />
 
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**[[5a01]] – DmO-GT catalytic domain (mutant) – ''Drosophila melanogaster''<br />
 
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**[[6p61]] – GT – ''Leptospira borgpetersenii''<br />
 
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*Various GT complexes
 
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**[[1nzd]] – T4β-GT + UDP-glucose – Phage T4
 
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**[[2nzf]], [[1nzf]] - T4β-GT (mutant) + UDP-glucose<br />
 
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**[[3vmr]], [[3vms]], [[3vmt]] – SaGT + lipid II analog<br />
 
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**[[3mbo]] – BaGT + UDP + malate <br />
 
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**[[3oy7]] – PcvGT + GDP-mannose <br />
 
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**[[3q3h]] – ApGT + UDP-Glc<br />
 
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**[[1pn3]], [[1pnv]], [[1rrv]] – AoGT + TDP + vancomycin<br />
 
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**[[4rb4]] – EcGT (mutant) + ADP-heptose<br />
 
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**[[2yjn]] – GT + Dtpd-4-keto-6-deoxy-hexose isomerase – ''Saccharopolyspora erythraea''<br />
 
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**[[2xcu]] – AaGT + CMP<br />
 
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**[[3iaa]] – MeGT Calg2 + TDP
 
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**[[3rsc]] - MeGT Calg2 + TDP + calicheamicin<br />
 
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**[[4ayj]] – BoGT + glucose + galactose + fucose <br />
 
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**[[4cj8]], [[4cjc]] - BoGT (mutant) + UDP + galactosamine + UDP-galactosamine <br />
 
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**[[4cjb]] - BoGT (mutant) + GalNac <br />
 
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**[[1g9r]] - GT (mutant) + UDP-galactose + Mn – ''Neisseria meningitides''<br />
 
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**[[3wag]] – ShGT + DTDP<br />
 
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**[[5ekp]] - SyGT + UDP – ''Synechosystis''<br />
 
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**[[5eke]] - SyGT (mutant) + UDP <br />
 
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**[[5e9u]], [[5e9t]] - GT + UDP + GlcNac + GT chaperone – ''Streptococcus gordonii''<br />
 
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**[[6ejj]] - CjGT + nerylneryl pyrophosphate + UDP - ''Campylobacter jejuni''<br />
 
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**[[6eji]] - CjGT + UDP-galactosamine <br />
 
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**[[6ejk]] - CjGT + nerylneryl pyrophosphate + UDP-galactosamine <br />
 
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**[[5v4a]] - GT + UDP – ''Streptococcus sanguinis''<br />
 
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*β-1,4-galactosyltransferase 1 (BGT)
 
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**[[6fwu]], [[6fwt]] - hBGT 1 catalytic domain<br />
 
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**[[2fy7]] - hBGT 1 catalytic domain (mutant) <br />
 
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**[[1fgx]] - bBGT 1 catalytic domain – bovine<br />
 
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**[[1pzt]], [[4krv]] - bBGT 1 catalytic domain (mutant) <br />
 
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**[[3lw6]] - DmBGT 7 catalytic domain (mutant)
 
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*''BGT 1 binary complexes''
 
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**[[1oqm]] - bBGT catalytic domain + UDP-N-acetylgalactosamine<br />
 
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**[[2fya]] - hBGT 1 catalytic domain (mutant) + Mn<br />
 
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**[[4ee3]], [[4ee4]], [[4ee5]], [[4eea]], [[4eeg]], [[4eem]], [[4eeo]] - hBGT 1 catalytic domain (mutant) + polysaccharide<br />
 
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**[[1fr8]], [[1o0r]] - bBGT 1 catalytic domain + UDP-galactose<br />
 
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**[[1tw5]] - bBGT catalytic domain (mutant) + chitobiose<br />
 
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**[[1nf5]] - bBGT + α-lactalbumin<br />
 
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**[[4l41]] - bBGT 1 (mutant) + α-lactalbumin<br />
 
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**[[1o23]] - bBGT catalytic domain + UDP-glucose<br />
 
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**[[1oqm]] - bBGT catalytic domain + UDP-N-acetylgalactosamine<br />
 
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*''BGT 1 ternary complexes''
 
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**[[2fyb]] - hBGT 1 catalytic domain (mutant) + Mn + UDP<br />
 
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**[[2ae7]]- hBGT 1 catalytic domain + UDP + pentasaccharide<br />
 
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**[[2aec]], [[2aes]], [[2agd]] - hBGT 1 catalytic domain + UDP + GlcNAc + mannose<br />
 
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**[[2fyc]] - hBGT 1 catalytic domain (mutant) + UDP-galactose + Ca + α-lactalbumin<br />
 
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**[[3ee5]] - hBGT 1 catalytic domain (mutant) + UDP + GlcNAc-β1,3-gal-β-naphthalenemethanol<br />
 
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**[[2fyd]] - hBGT 1 catalytic domain + UDP-GlcNAc + Mn + α-lactalbumin<br /> (mutant) + glucose<br />
 
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**[[2ah9]] - hBGT 1 catalytic domain + UDP + chitotriose<br />
 
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**[[1nhe]], [[1nkh]] - bBGT 1 catalytic domain + UDP + α-lactalbumin<br />
 
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**[[1yro]] - bBGT 1 catalytic domain (mutant) + UDP-galactose + α-lactalbumin<br />
 
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**[[1nwg]] - bBGT catalytic domain + N-butanoyl-glucoamine + α-lactalbumin<br />
 
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**[[1nmm]], [[1nqi]], [[1pzy]], [[1o7q]] - bBGT 1 catalytic domain + UDP + GlcNAc<br />
 
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*β-1,4-galactosyltransferase 7 (BGT)
 
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**[[1tvy]], [[1tw1]], [[4lw3]] - bBGT 7 catalytic domain (mutant) + UDP-galactose<br />
 
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**[[4irq]], [[4irp]] - bBGT 7 catalytic domain + UDP<br />
 
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**[[4lw6]] - bBGT 7 catalytic domain + xylobiose<br />
 
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**[[4m4k]] - bBGT 7 catalytic domain (mutant) + UDP-galactose + xylobiose<br />
 
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**[[3lw6]] - DmBGT 7 catalytic domain (mutant)<br />
 
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*α-1,3-galactosyltransferase (AGT)
 
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**[[1vzu]], [[1vzx]], [[2i7b]] - hAGT catalytic domain (mutant)<br />
 
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**[[2i7b]] - hAGT catalytic domain (mutant)<br />
 
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**[[1g8o]], [[1fg5]], [[2jco]] - bAGT catalytic domain<br />
 
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**[[2jcl]] – bAGT catalytic domain (mutant) <br />
 
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*''AGT binary complexes''
 
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**[[1ziz]], [[1zjp]] - hAGT catalytic domain + galactose<br />
 
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**[[1zj0]] - hAGT catalytic domain + lactose<br />
 
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**[[1zj1]] - hAGT catalytic domain + N-acetyl lactosamine<br />
 
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**[[1zj2]], [[1zj3]] - hAGT catalytic domain + trisaccharide<br />
 
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**[[2a8u]], [[2a8w]] - hAGT catalytic domain + methyl lactoside<br />
 
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**[[1g93]], [[1gx0]] - bAGT catalytic domain + UDP-galactose<br />
 
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**[[1k4v]] - bAGT catalytic domain + UDP<br />
 
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**[[2rj0]] - bAGT catalytic domain + UDP + Mn<br />
 
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**[[1vzt]], [[2jcj]] - bAGT catalytic domain (mutant) + UDP<br />
 
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**[[2vfz]] - bAGT catalytic domain (mutant) + UDP-2F-galactose<br />
 
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**[[2vs4]], [[2vs5]], [[2vxl]], [[2vxm]], [[2vs3]] - bAGT catalytic domain (mutant) + UDP-galactose<br />
 
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**[[2vs3]] - bAGT catalytic domain + UDP-galactose<br />
 
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*''AGT ternary complexes''
 
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**[[1r7u]], [[1r7x]] - hAGT catalytic domain + inhibitor + fucose<br />
 
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**[[1r80]] - hAGT catalytic domain + UDP + inhibitor + fucose<br />
 
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**[[1r82]] - hAGT catalytic domain + UDP-galactose + inhibitor + fucose<br />
 
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**[[1gwv]] - bAGT catalytic domain + UDP + lactose<br />
 
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**[[2jck]] - bAGT catalytic domain (mutant) + UDP + Mn<br />
 
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**[[2wgz]] - bAGT catalytic domain + UDP + nitrophenyl-β-galactoside<br />
 
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**[[1o7o]] - bAGT catalytic domain (mutant) + UDP + lactose<br />
 
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**[[1gx4]] - bAGT catalytic domain + UDP + N-acetyl lactosamine<br />
 
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**[[1gww]] - bAGT catalytic domain + UDP + glucose<br />
 
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*Fucosylglycoprotein 3-AGT (GTB) or histo-blood group ABO system transferase
 
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**[[2rit]], [[4kxo]] – hGTB<br />
 
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**[[2pgv]], [[2pgy]], [[2riz]], [[2rj5]], [[1wsz]], [[2o1f]], [[2o1g]], [[5cql]], [[5cqm]], [[5cqn]], [[5cqo]], [[5cqp]], [[5cmf]], [[5cmg]], [[5cmh]], [[5cmi]], [[5cmj]], [[3ioh]], [[6bjm]], [[6bjl]], [[6bjk]], [[6bjj]], [[6bji]], [[6gwz]], [[6gwy]], [[6gx2]], [[6gx1]], [[6gx0]] – hGTB (mutant) <br />
 
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**[[2rix]] – hGTB + UDP<br />
 
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**[[3ioj]], [[2olh]], [[5m7b]], [[5m7c]], [[5m7d]] – hGTB (mutant) + UDP<br />
 
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**[[4gbp]], [[4frq]], [[4fqw]], [[4fre]], [[4frh]], [[4frl]], [[4frm]], [[4fro]], [[4frp]], [[3sxa]], [[3sxb]] – hGTB + UDP-galactose<br />
 
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**[[4fra]], [[4frb]], [[4frd]], [[3zgf]], [[3zgg]], [[3v0l]], [[3v0m]], [[3v0n]], [[3v0o]], [[3ioi]] – hGTB (mutant) + UDP-galactose<br />
 
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**[[5m79]], [[5m7a]] – hGTB (mutant) + UMP<br />
 
-
**[[4y62]], [[4y63]], [[4y64]] - hGTB + amino acid analog<br />
 
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**[[3u0x]] – hGTB + inhibitor<br />
 
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**[[3u0y]] – hGTB (mutant) + UDP + inhibitor<br />
 
-
**[[2riy]] – hGTB + H-antigen acceptor<br />
 
-
**[[1zi4]], [[1zi5]] - hGTB + H-antigen<br />
 
-
**[[3i0j]] – hGTB Abo (mutant) + H-antigen<br />
 
-
**[[2rj1]], [[2rj6]] - hGTB (mutant) + UDP + H-antigen disaccharide<br />
 
-
**[[2rj8]] - hGTB + UDP + H-antigen disaccharide<br />
 
-
**[[5tjk]], [[5tjl]], [[5tjn]], [[5tjo]] - hGTB  + UDP + H-antigen trisaccharide<br />
 
-
**[[5c49]] - hGTB (mutant) + UDP-galactose + H-antigen <br />
 
-
**[[2rj4]] - hGTB (mutant) + UDP + ADA<br />
 
-
**[[5bxc]] - hGTB + UDP + deoxy-acceptor<br />
 
-
**[[5c1g]], [[5c1h]], [[4c2s]] - hGTB (mutant) + UDP + deoxy-acceptor<br />
 
-
**[[2rj9]], [[5c36]], [[5c1l]] - hGTB + UDP-galactose + deoxy-acceptor<br />
 
-
**[[2rj7]], [[5c47]], [[5c48]], [[5c38]], [[5c3a]], [[5c3b]], [[5c3d]], [[3v0p]], [[3v0q]] - hGTB (mutant) + UDP-galactose + deoxy-acceptor<br />
 
-
**[[5c8r]], [[5c4b]] - hGTB + UDP-glucose + deoxy-acceptor<br />
 
-
**[[5c4c]], [[5c4d]], [[5c4e]], [[5c4f]] - hGTB (mutant) + UDP-glucose + deoxy-acceptor<br />
 
-
**[[3sx3]], [[3sx5]], [[3sx7]], [[3sx8]], [[3sxc]], [[3sxd]], [[3sxe]], [[3sxg]], [[1zhj]], [[1zjo]] - hGTB catalytic domain + galactose<br />
 
-
**[[1zi1]] - hGTB catalytic domain + lactose<br />
 
-
**[[1zi3]] - hGTB catalytic domain + acetylactosamine
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:33, 16 July 2019

Cyclodextrin glycosyltransferase complex with substrate maltoheptaose, maltose and Ca+2 ions, 1cxh

Drag the structure with the mouse to rotate

References

  1. ↑ Williams GJ, Thorson JS. Natural product glycosyltransferases: properties and applications. Adv Enzymol Relat Areas Mol Biol. 2009;76:55-119. PMID:18990828
  2. ↑ Qasba PK, Ramakrishnan B, Boeggeman E. Structure and function of beta -1,4-galactosyltransferase. Curr Drug Targets. 2008 Apr;9(4):292-309. PMID:18393823
  3. ↑ Jadhav SK, Patel KA, Dholakia BB, Khan BM. Structural characterization of a flavonoid glycosyltransferase from Withania somnifera. Bioinformation. 2012;8(19):943-9. doi: 10.6026/97320630008943. Epub 2012 Oct 1. PMID:23144555 doi:http://dx.doi.org/10.6026/97320630008943
  4. ↑ Yoshida A, Kobayashi K, Manya H, Taniguchi K, Kano H, Mizuno M, Inazu T, Mitsuhashi H, Takahashi S, Takeuchi M, Herrmann R, Straub V, Talim B, Voit T, Topaloglu H, Toda T, Endo T. Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. Dev Cell. 2001 Nov;1(5):717-24. PMID:11709191
  5. ↑ Knegtel RM, Strokopytov B, Penninga D, Faber OG, Rozeboom HJ, Kalk KH, Dijkhuizen L, Dijkstra BW. Crystallographic studies of the interaction of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 with natural substrates and products. J Biol Chem. 1995 Dec 8;270(49):29256-64. PMID:7493956

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