Gp41

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== Relevance ==
== Relevance ==
Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell<ref>PMID:15180542</ref>.
Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell<ref>PMID:15180542</ref>.
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== 3D Structures of Gp41 ==
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[[Gp41 3D Structures]]
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</StructureSection>
</StructureSection>
== 3D Structures of Gp41 ==
== 3D Structures of Gp41 ==
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**[[1aik]], [[1df4]], [[1df5]], [[1qr8]], [[1qr9]], [[1dlb]], [[1jpx]], [[1szt]], [[3vu5]], [[3vu6]] - Gp41 N-peptide domain <br />
**[[1aik]], [[1df4]], [[1df5]], [[1qr8]], [[1qr9]], [[1dlb]], [[1jpx]], [[1szt]], [[3vu5]], [[3vu6]] - Gp41 N-peptide domain <br />
**[[1env]], [[3cp1]], [[3cyo]], [[1f23]], [[1k33]], [[1k34]], [[1i5x]], [[1i5y]], [[2ot5]], [[5ka6]], [[5ka5]], [[4i2l]] – Gp41 N-peptide domain (mutant)<br />
**[[1env]], [[3cp1]], [[3cyo]], [[1f23]], [[1k33]], [[1k34]], [[1i5x]], [[1i5y]], [[2ot5]], [[5ka6]], [[5ka5]], [[4i2l]] – Gp41 N-peptide domain (mutant)<br />
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**[[2z2t]], [[2zzo]], [[3aha]], [[3vie]], [[2r3c]], [[2r5b]], [[2r5d]], [[3l36]], [[3l37]], [[3vgy]], [[3vh7]], [[3vtp]], [[5h0n]] – Gp41 N-peptide domain + fusion inhibitor peptide<br />
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**[[2z2t]], [[2zzo]], [[3aha]], [[3vie]], [[2r3c]], [[2r5b]], [[2r5d]], [[3l36]], [[3l37]], [[3vgy]], [[3vh7]], [[3vtp]], [[5h0n]], [[5zpw]] – Gp41 N-peptide domain + fusion inhibitor peptide<br />
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**[[6b3u]] – Gp41 transmembrane domain - NMR<br />
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**[[6b3u]], [[6dln]] – Gp41 transmembrane domain - NMR<br />
**[[5vwl]] – Gp41 tail domain - NMR<br />
**[[5vwl]] – Gp41 tail domain - NMR<br />
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**[[5v8l]], [[5v8m]], [[5uty]], [[5utf]], [[5um8]], [[5jsa]], [[5js9]], [[5i8h]], [[5d9q]], [[5cjx]], [[5c7k]], [[6ck9]], [[6chb]], [[6ch9]], [[6ch8]], [[6ch7]], [[5w6d]], [[4nrx]], [[5fyk]], [[5fyj]], [[4nco]] – Gp41 core + Gp120 + antibody<br />
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**[[5v8l]], [[5v8m]], [[5uty]], [[5utf]], [[5um8]], [[5jsa]], [[5js9]], [[5i8h]], [[5d9q]], [[5cjx]], [[5c7k]], [[6ck9]], [[6chb]], [[6ch9]], [[6ch8]], [[6ch7]], [[5w6d]], [[4nrx]], [[5fyk]], [[5fyj]], [[4nco]], [[6mdt]], [[6mco]] – Gp41 core + Gp120 + antibody<br />
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**[[6cdi]] – Gp41 core + Gp120 + antibody – Cryo EM<br />
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**[[6nnj]], [[6nnf]], [[6nm6]] – Gp41 core (mutant) + Gp120 + antibody<br />
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**[[6cdi]], [[6orn]], [[6oo]], [[6orp]], [[6orq]], [[6okp]], [[6nqd]], [[6mn7]], [[6cuf]], [[6cue]] – Gp41 core + Gp120 + antibody – Cryo EM<br />
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**[[6nc3]], [[6nc2]] – Gp41 core (mutant) + Gp120 + antibody – Cryo EM<br />
**[[5u1f]], [[5thr]] – Gp41 core + Gp120 + antibody + CD4<br />
**[[5u1f]], [[5thr]] – Gp41 core + Gp120 + antibody + CD4<br />
**[[5hm1]] – Gp41 core + llama antibody <br />
**[[5hm1]] – Gp41 core + llama antibody <br />

Revision as of 08:47, 17 July 2019

Core structure of acetylated gp41 from the HIV envelope glycoprotein, 1aik.

Drag the structure with the mouse to rotate

3D Structures of Gp41

Updated on 17-July-2019

References

  1. Chan DC, Kim PS. HIV entry and its inhibition. Cell. 1998 May 29;93(5):681-4. PMID:9630213
  2. Root MJ, Steger HK. HIV-1 gp41 as a target for viral entry inhibition. Curr Pharm Des. 2004;10(15):1805-25. PMID:15180542

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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