6d4p

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'''Unreleased structure'''
 
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The entry 6d4p is ON HOLD until Paper Publication
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==Ube2D1 in complex with ubiquitin variant Ubv.D1.1==
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<StructureSection load='6d4p' size='340' side='right'caption='[[6d4p]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6d4p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D4P FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d4p OCA], [http://pdbe.org/6d4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d4p RCSB], [http://www.ebi.ac.uk/pdbsum/6d4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d4p ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/UB2D1_HUMAN UB2D1_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.<ref>PMID:18042044</ref> <ref>PMID:18359941</ref> <ref>PMID:19103148</ref> <ref>PMID:19854139</ref> <ref>PMID:20061386</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Ceccarelli, D F]]
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[[Category: Garg, P]]
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[[Category: Sicheri, F]]
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[[Category: Sidhu, S]]
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[[Category: Transferase]]
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[[Category: Ubiquitin]]
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[[Category: Ubiquitin conjugating enzyme]]
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[[Category: Ubiquitin variant]]

Revision as of 10:36, 17 July 2019

Ube2D1 in complex with ubiquitin variant Ubv.D1.1

PDB ID 6d4p

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